Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study

Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study Publisher Pubmed

Feigin VL^{1, 2, 3} ; Vos T^{2, 4} ; Alahdab F⁵ ; Amit AML^{6, 7} ; Barnighausen TW^{8, 9} ; Beghi E¹⁰ ; Beheshti M¹¹ ; Chavan PP¹² ; Criqui MH¹³ ; Desai R¹⁴ ; Dhamminda Dharmaratne S^{2, 4, 15} ; Dorsey ER¹⁶ ; Wilder Eagan A^{17, 18} ; Elgendy IY^{19, 20} Show All Authors

Feigin VL^{1, 2, 3}
Vos T^{2, 4}
Alahdab F⁵
Amit AML^{6, 7}
Barnighausen TW^{8, 9}
Beghi E¹⁰
Beheshti M¹¹
Chavan PP¹²
Criqui MH¹³
Desai R¹⁴
Dhamminda Dharmaratne S^{2, 4, 15}
Dorsey ER¹⁶
Wilder Eagan A^{17, 18}
Elgendy IY^{19, 20}
Filip I^{21, 22}
Giampaoli S²³
Giussani G²⁴
Hafezinejad N^{25, 26}
Hole MK²⁷
Ikeda T²⁸
Owens Johnson C²
Kalani R²⁹
Khatab K^{30, 31}
Khubchandani J³²
Kim D³³
Koroshetz WJ³⁴
Krishnamoorthy V^{35, 36}
Krishnamurthi RV¹
Liu X³⁷
Lo WD^{38, 39}
Logroscino G^{40, 41}
Mensah GA^{42, 43}
Miller TR^{44, 45}
Mohammed S^{46, 47}
Mokdad AH^{2, 4}
Moradilakeh M⁴⁸
Morrison SD⁴⁹
Shivamurthy VKN⁵⁰
Naghavi M^{2, 4}
Nichols E²
Norrving B⁵¹
Odell CM²
Pupillo E¹⁰
Radfar A⁵²
Roth GA^{2, 4, 53}
Shafieesabet A^{54, 55}
Sheikh A^{56, 57}
Sheikhbahaei S²⁵
Shin JI⁵⁸
Singh JA^{59, 60}
Steiner TJ^{61, 62}
Stovner LJ^{61, 63}
Wallin MT^{64, 65}
Weiss J⁶⁶
Wu C^{67, 68}
Zunt JR²⁹
Adelson JD²
Murray CJL^{2, 4}

Show Affiliations

1. National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Sciences, Auckland University of Technology, School of Public Health and Psychosocial Studies, 90 Akoranga Dr, Northcote, Auckland, 0627, New Zealand
2. Institute for Health Metrics and Evaluation, University of Washington, Population Health Building, Hans Rosling Center, 3980 15th Ave NE, Seattle, 98195, WA, United States
3. Research Center of Neurology, Moscow, Russian Federation
4. Department of Health Metrics Sciences, University of Washington, School of Medicine, Seattle, United States
5. Mayo Evidence-Based Practice Center, Mayo Clinic Foundation for Medical Education and Research, Rochester, MN, United States
6. Department of Epidemiology and Biostatistics, University of the Philippines Manila, Manila, Philippines
7. Johns Hopkins University, School of Public Health, Baltimore, MD, United States
8. Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany
9. Harvard University T.H. Chan, School of Public Health, Boston, MA, United States
10. Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
11. Department of Physical Medicine and Rehabilitation, New York University, New York, United States
12. Department of Epidemiology and Environmental Health, University of Buffalo, Buffalo, NY, United States
13. Department of Family Medicine and Public Health, University of California, San Diego, San Diego, United States
14. Division of Cardiology, Atlanta Veterans Affairs Medical Center, Decatur, GA, United States
15. Department of Community Medicine, University of Peradeniya, Peradeniya, Sri Lanka
16. University of Rochester, Rochester, NY, United States
17. Department of Global Health and Social Medicine, Harvard University, Boston, MA, United States
18. Department of Social Services, Tufts Medical Center, Boston, MA, United States
19. Division of Cardiology, Massachusetts General Hospital, Boston, United States
20. Division of Cardiology, Harvard University, Boston, MA, United States
21. Psychiatry Department, Kaiser Permanente, Fontana, CA, United States
22. A.T. Still University School of Osteopathic Medicine in Arizona, Arizona School of Health Sciences, Mesa, AZ, United States
23. Department of Cardiovascular Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanita (Italian National Institute of Health), Rome, Italy
24. Laboratory of Neurological Disorders, Mario Negri Institute for Pharmacological Research, Milan, Italy
25. Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States
26. Tehran University of Medical Sciences, School of Medicine, Tehran, Iran
27. Department of Pediatrics, University of Texas, Austin, United States
28. Department of Biostatistics and Epidemiology, Auckland University of Technology, Auckland, New Zealand
29. Department of Neurology, University of Washington, Seattle, United States
30. Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, United Kingdom
31. Ohio University, College of Arts and Sciences, Zanesville, United States
32. Department of Nutrition and Health Science, Ball State University, Muncie, IN, United States
33. Department of Health Sciences, Northeastern University, Boston, MA, United States
34. National Institutes of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, United States
35. Department of Anesthesiology, Duke University, Durham, NC, United States
36. Department of Anesthesiology, University of Washington, Seattle, United States
37. Department of Systems Populations, and Leadership, University of Michigan, Ann Arbor, United States
38. Department of Pediatrics, Ohio State University, Columbus, United States
39. Department of Pediatric Neurology, Nationwide Children's Hospital, Columbus, OH, United States
40. Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy
41. Department of Clinical Research in Neurology, Fondazione Cardinale Giovanni Panico Hospital, Tricase, Italy
42. Center for Translation Research and Implementation Science, National Institutes of Health, Bethesda, MD, United States
43. Department of Medicine, University of Cape Town, Cape Town, South Africa
44. Pacific Institute for Research and Evaluation, Calverton, MD, United States
45. School of Public Health, Curtin University, Perth, Australia
46. Department of Biomolecular Sciences, University of Mississippi, Oxford, United Kingdom
47. Department of Pharmacy, Mizan-Tepi University, Mizan, Ethiopia
48. Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran
49. Section of Plastic Surgery, University of Michigan, Ann Arbor, United States
50. Department of Neurology, Emory University, Atlanta, GA, United States
51. Department of Clinical Sciences, Lund University, Lund, Sweden
52. University of Central Florida, College of Medicine, Orlando, United States
53. Division of Cardiology, University of Washington, Seattle, United States
54. Department of Cardiology, Charite Medical University Berlin, Berlin, Germany
55. Center for Stroke Research Berlin, Berlin, Germany
56. Centre for Medical Informatics, University of Edinburgh, Edinburgh, United Kingdom
57. Division of General Internal Medicine, Harvard University, Boston, MA, United States
58. Yonsei University College of Medicine, Seoul, South Korea
59. University of Alabama at Birmingham, School of Medicine, Birmingham, United States
60. Medicine Service, US Department of Veterans Affairs, Birmingham, AL, United States
61. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway
62. Division of Brain Sciences, Imperial College London, London, United Kingdom
63. Department of Neurology and Clinical Neurophysiology, St Olavs Hospital, Trondheim, Norway
64. Department of Neurology, George Washington University, Washington, DC, United States
65. University of Maryland, School of Medicine, Baltimore, United States
66. Department of Demography, University of California, Berkeley, Berkeley, United States
67. Global Health Research Center, Duke Kunshan University, Kunshan, China
68. Duke Global Health Institute, Duke University, Durham, NC, United States

Source: JAMA Neurology Published:2021

Abstract

Importance: Accurate and up-to-date estimates on incidence, prevalence, mortality, and disability-adjusted life-years (burden) of neurological disorders are the backbone of evidence-based health care planning and resource allocation for these disorders. It appears that no such estimates have been reported at the state level for the US. Objective: To present burden estimates of major neurological disorders in the US states by age and sex from 1990 to 2017. Design, Setting, and Participants: This is a systematic analysis of the Global Burden of Disease (GBD) 2017 study. Data on incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) of major neurological disorders were derived from the GBD 2017 study of the 48 contiguous US states, Alaska, and Hawaii. Fourteen major neurological disorders were analyzed: stroke, Alzheimer disease and other dementias, Parkinson disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, traumatic brain injury, spinal cord injuries, brain and other nervous system cancers, meningitis, encephalitis, and tetanus. Exposures: Any of the 14 listed neurological diseases. Main Outcome and Measure: Absolute numbers in detail by age and sex and age-standardized rates (with 95% uncertainty intervals) were calculated. Results: The 3 most burdensome neurological disorders in the US in terms of absolute number of DALYs were stroke (3.58 [95% uncertainty interval [UI], 3.25-3.92] million DALYs), Alzheimer disease and other dementias (2.55 [95% UI, 2.43-2.68] million DALYs), and migraine (2.40 [95% UI, 1.53-3.44] million DALYs). The burden of almost all neurological disorders (in terms of absolute number of incident, prevalent, and fatal cases, as well as DALYs) increased from 1990 to 2017, largely because of the aging of the population. Exceptions for this trend included traumatic brain injury incidence (-29.1% [95% UI, -32.4% to -25.8%]); spinal cord injury prevalence (-38.5% [95% UI, -43.1% to -34.0%]); meningitis prevalence (-44.8% [95% UI, -47.3% to -42.3%]), deaths (-64.4% [95% UI, -67.7% to -50.3%]), and DALYs (-66.9% [95% UI, -70.1% to -55.9%]); and encephalitis DALYs (-25.8% [95% UI, -30.7% to -5.8%]). The different metrics of age-standardized rates varied between the US states from a 1.2-fold difference for tension-type headache to 7.5-fold for tetanus; southeastern states and Arkansas had a relatively higher burden for stroke, while northern states had a relatively higher burden of multiple sclerosis and eastern states had higher rates of Parkinson disease, idiopathic epilepsy, migraine and tension-type headache, and meningitis, encephalitis, and tetanus. Conclusions and Relevance: There is a large and increasing burden of noncommunicable neurological disorders in the US, with up to a 5-fold variation in the burden of and trends in particular neurological disorders across the US states. The information reported in this article can be used by health care professionals and policy makers at the national and state levels to advance their health care planning and resource allocation to prevent and reduce the burden of neurological disorders.. © 2021 American Medical Association. All rights reserved.

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Style	Citing Format
MLA	Feigin VL, et al.. "Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study." JAMA Neurology, vol. 78, no. 2, 2021, pp. 165-176.
APA	Feigin VL, Vos T, Alahdab F, Amit AML, Barnighausen TW, Beghi E, Beheshti M, Chavan PP, Criqui MH, Desai R, Dhamminda Dharmaratne S, Dorsey ER, Wilder Eagan A, Elgendy IY, Filip I, Giampaoli S, Giussani G, Hafezinejad N, Hole MK, ... Murray CJL (2021). Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study. JAMA Neurology, 78(2), 165-176.
Chicago	Feigin VL, Vos T, Alahdab F, Amit AML, Barnighausen TW, Beghi E, Beheshti M, et al.. "Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study." JAMA Neurology 78, no. 2 (2021): 165-176.
Harvard	Feigin VL et al. (2021) 'Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study', JAMA Neurology, 78(2), pp. 165-176.
Vancouver	Feigin VL, Vos T, Alahdab F, Amit AML, Barnighausen TW, Beghi E, et al.. Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study. JAMA Neurology. 2021;78(2):165-176.
BibTex	@article{ author = {Feigin VL and Vos T and Alahdab F and Amit AML and Barnighausen TW and Beghi E and Beheshti M and Chavan PP and Criqui MH and Desai R and Dhamminda Dharmaratne S and Dorsey ER and Wilder Eagan A and Elgendy IY and Filip I and Giampaoli S and Giussani G and Hafezinejad N and Hole MK and Ikeda T and Owens Johnson C and Kalani R and Khatab K and Khubchandani J and Kim D and Koroshetz WJ and Krishnamoorthy V and Krishnamurthi RV and Liu X and Lo WD and Logroscino G and Mensah GA and Miller TR and Mohammed S and Mokdad AH and Moradilakeh M and Morrison SD and Shivamurthy VKN and Naghavi M and Nichols E and Norrving B and Odell CM and Pupillo E and Radfar A and Roth GA and Shafieesabet A and Sheikh A and Sheikhbahaei S and Shin JI and Singh JA and Steiner TJ and Stovner LJ and Wallin MT and Weiss J and Wu C and Zunt JR and Adelson JD and Murray CJL}, title = {Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study}, journal = {JAMA Neurology}, volume = {78}, number = {2}, pages = {165-176}, year = {2021} }
RIS	TY - JOUR AU - Feigin VL AU - Vos T AU - Alahdab F AU - Amit AML AU - Barnighausen TW AU - Beghi E AU - Beheshti M AU - Chavan PP AU - Criqui MH AU - Desai R AU - Dhamminda Dharmaratne S AU - Dorsey ER AU - Wilder Eagan A AU - Elgendy IY AU - Filip I AU - Giampaoli S AU - Giussani G AU - Hafezinejad N AU - Hole MK AU - Ikeda T AU - Owens Johnson C AU - Kalani R AU - Khatab K AU - Khubchandani J AU - Kim D AU - Koroshetz WJ AU - Krishnamoorthy V AU - Krishnamurthi RV AU - Liu X AU - Lo WD AU - Logroscino G AU - Mensah GA AU - Miller TR AU - Mohammed S AU - Mokdad AH AU - Moradilakeh M AU - Morrison SD AU - Shivamurthy VKN AU - Naghavi M AU - Nichols E AU - Norrving B AU - Odell CM AU - Pupillo E AU - Radfar A AU - Roth GA AU - Shafieesabet A AU - Sheikh A AU - Sheikhbahaei S AU - Shin JI AU - Singh JA AU - Steiner TJ AU - Stovner LJ AU - Wallin MT AU - Weiss J AU - Wu C AU - Zunt JR AU - Adelson JD AU - Murray CJL TI - Burden of Neurological Disorders Across the Us From 1990-2017: A Global Burden of Disease Study JO - JAMA Neurology VL - 78 IS - 2 SP - 165 EP - 176 PY - 2021 ER -

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