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Advances in Targeted Nano-Delivery of Bevacizumab Using Nanoparticles: Current Insights, Innovations, and Future Perspectives Publisher



Fatima I1 ; Zeinalilathori S2 ; Qindeel M3 ; Kharaba Z4 ; Sahebzade MS5 ; Rahdar A6, 7 ; Zeinali S8 ; Fathikarkan S9, 10 ; Khan A1 ; Ghazy E11 ; Pandey S12, 13
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan
  2. 2. Department of Chemistry and Biochemistry, University of Delaware, United States
  3. 3. Department of Pharmaceutics, Hamdard University Islamabad, Campus, Islamabad, Pakistan
  4. 4. Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates
  5. 5. Department of Medicine Science, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Physics, Faculty of Sciences, University of Zabol, Zabol, 538-98615, Iran
  7. 7. Key labratory of Modeling and simulation-based Reliability and Optimizition, University of Zabol, Zabol, Iran
  8. 8. Harper & Keele Veterinary School, Keele University, Staffordshire, United Kingdom
  9. 9. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, 94531-55166, Iran
  10. 10. Department of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 9414974877, Iran
  11. 11. Department of Pharmacy, Al-Rasheed University College, Baghdad, Iraq
  12. 12. School of Bioengineering and Food Technology, Faculty of Applied Sciences and Biotechnology, Shoolini University, Himachal Pradesh, Solan, 173229, India
  13. 13. Department of Chemistry, College of Natural Science, Yeungnam University, 280 Daehak-Ro, Gyeongbuk, Gyeongsan, 38541, South Korea

Source: Journal of Drug Delivery Science and Technology Published:2024


Abstract

This review article examines the transformative impact of bevacizumab (Avastin®) in cancer therapy over the past years, focusing on its future potential in oncological applications. Bevacizumab (BCZ), a humanized antibody targeting vascular endothelial growth factor (VEGF), has become a cornerstone in cancer treatment due to its angiogenesis inhibiting properties. The article highlights clinical advancements, such as the development of innovative formulations like cationic liposome conjugation and PEGylated nanoparticles, which enhance targeted delivery and reduce systemic toxicity, improving patient outcomes. The review also delves into the pharmacological challenges of BCZ, including its stability and handling of acidic and basic charge variants. Emerging research on anti-VEGF prolonged release systems and sophisticated drug delivery mechanisms, such as stimuli-responsive hydrogels and nanoparticles, underlines the shift towards personalized medicine. The review highlights the ongoing efforts and challenges in translating these nanomedicine innovations from bench to bedside, as evidenced by qualitative studies and clinical trials data. The review underscores the need for continued innovation and research in this area, emphasizing the pivotal role of BCZ in transforming cancer treatment paradigms. © 2024 Elsevier B.V.
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