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Mir-370 Expression Analysis in Breast Cancer



Mollainezhad H1 ; Eskandari N2 ; Pourazar A1 ; Andalib A1 ; Salehi M3 ; Ganjalikhanihakemi M1
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Isfahan University of Medical sciences, Isfahan, Iran
  2. 2. Department of Immunology, School of Medicine, Applied Physiology Research Center, Isfahan University of Medical sciences, Isfahan, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: MicroRNAs (MiRNAs) are 21-24 nucleotides which have different levels of expression between tumors and normal tissues. In this study, we analyzed the expression level of miR-370 in different stages and grades of human breast cancer tissues compared with adjacent normal tissues. Methods: In this case-control study, the expression of miR-370 on 22 tissue samples (tumor and normal) from patients with breast cancer was investigated via quantitative real-time polymerase chain reaction method. Findings: miR-370 expression showed a significant increase in tumor tissues compared to normal tissues (P = 0.001) as well as in cancer tissues at stage III (P = 0.004) and grade 3 (P = 0.011) than in other stages. Conclusion: According to evaluation of miR-370 expression in different stages and grades and its relation to more advanced tumor stages/grades, it can possibility act as oncomiRNA in breast cancer. It may be suggested as a prognostic biomarker or therapeutic target in breast cancer, too. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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