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Recent Progress in the Application of Amidines for the Synthesis of N-Heterocyclic Compounds Publisher



Doraghi F1 ; Karimian S2 ; Navid H3 ; Ghanbarlou M1 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Source: Monatshefte fur Chemie Published:2024


Abstract

Nitrogen-containing heterocycles are an inseparable part of many biologically active compounds. Therefore, the synthesis of these structures is of great importance in the field of synthetic chemistry. Due to the presence of two nitrogen atoms in the amidine structure, this molecule can be considered as a dual nucleophile in the synthesis of various heterocycles. The current review highlights recent advances in the application of amidines, in particular, N-arylamidines, as versatile precursors in transition metal-catalyzed, and metal-free reactions for the construction of N-heterocyclic compounds. Graphical abstract: (Figure presented.). © Springer-Verlag GmbH Austria, part of Springer Nature 2024.