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Crosstalk Between Lncrnas in the Apoptotic Pathway and Therapeutic Targets in Cancer Publisher Pubmed



Ebrahimi N1 ; Parkhideh S2 ; Samizade S3 ; Esfahani AN3 ; Samsami S4 ; Yazdani E5, 6 ; Adelian S7 ; Chaleshtori SR8 ; Shahamiri K7 ; Ahmadi A9 ; Aref AR10
Authors
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Authors Affiliations
  1. 1. Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Iran
  2. 2. Research Institute for Oncology, Hematology and Cell Therapy, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Cellular and molecular, School of Biological Sciences, Islamic Azad University of Falavarjan, Iran
  4. 4. Biotechnology department of Fasa University of medical science, Fasa, Iran
  5. 5. Department of Biology, Faculty of Science, University Of Isfahan, Isfahan, Iran
  6. 6. Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  7. 7. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  8. 8. Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Iran
  9. 9. Department of Biological Science and Technology, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr, 75169, Iran
  10. 10. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, MA, United States

Source: Cytokine and Growth Factor Reviews Published:2022


Abstract

The assertion that a significant portion of the mammalian genome has not been translated and that non-coding RNA accounts for over half of polyadenylate RNA have received much attention. In recent years, increasing evidence proposes non-coding RNAs (ncRNAs) as new regulators of various cellular processes, including cancer progression and nerve damage. Apoptosis is a type of programmed cell death critical for homeostasis and tissue development. Cancer cells often have inhibited apoptotic pathways. It has recently been demonstrated that up/down-regulation of various lncRNAs in certain types of tumors shapes cancer cells' response to apoptotic stimuli. This review discusses the most recent studies on lncRNAs and apoptosis in healthy and cancer cells. In addition, the role of lncRNAs as novel targets for cancer therapy is reviewed here. Finally, since it has been shown that lncRNA expression is associated with specific types of cancer, the potential for using lncRNAs as biomarkers is also discussed. © 2022 Elsevier Ltd
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