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Transition Metal-Catalyzed Cross-Coupling Reactions of N-Aryl-2-Aminopyridines Publisher



Doraghi F1 ; Rezainia L2 ; Morshedsolouk MH1, 2 ; Navid H2 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Source: RSC Advances Published:2025


Abstract

Due to the presence of the pyridyl directing group, N-aryl-2-aminopyridines can quickly form stable complexes with metals, leading to cyclization and functionalization reactions. A large number of N-heterocycles and nitrogen-based molecules can be easily constructed via this direct and atom-economical cross-coupling strategy. In this review, we have highlighted the transformations of N-aryl-2aminopyridines in the presence of various transition metal catalysts, such as palladium, rhodium, iridium, ruthenium, cobalt and copper. © 2025 The Author(s)