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Prostate Cancer and Noncoding Rnas: A Focus on Mirnas, Lncrnas, and Circrnas Publisher



Nazari A1 ; Osati P2 ; Fakhr SS3 ; Akhoundattar M4 ; Far NP5 ; Rajabi M6 ; Seyed Karimi M7 ; Ebrahimi N8 ; Hajifatahaliha M9 ; Aref AR10, 11
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Chemical Engineering, Fouman Faculty of Engineering, College of Engineering, University of Tehran, Tehran, Iran
  3. 3. Department of Biotechnology, Faculty of Applied Ecology, Agricultural Science and Biotechnology, Campus Hamar, Inland Norway University of Applied Sciences, Hamar, Norway
  4. 4. Department of Biology, Faculty of Sciences, Yazd University, Yazd, Iran
  5. 5. Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran
  6. 6. Department of Genetics, Faculty of Basic Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Surgery and Anesthesiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  9. 9. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Mass General Cancer Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
  11. 11. Broad Institute of MIT and Harvard, Harvard Medical School, Cambridge, MA, United States

Source: Prostate Cancer: Molecular Events and Therapeutic Modalities Published:2024


Abstract

Noncoding RNAs (ncRNAs) are a class of regulatory transcripts that play important functions in the pathogenesis of several cancer types, including prostate cancer (PCa). Within the framework of prostate cancer, non-coding RNAs have the capacity to function as either oncogenic or tumor-suppressive agents. ncRNAs have the potential to participate in the prostate cancer progression by influencing the signaling of the androgen receptor (AR), the degradation process of AR via ubiquitin-proteasome pathways, or other critical signaling pathways. This chapter provides a detailed review of the involvement of ncRNAs in the evolutionary processes of PCa, with a particular emphasis on their significance in the development of innovative biomarker profiles and targets for cancer treatment. © The Author(s). All rights reserved.
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