Synthesis of Novel Fused Quinazolinone Derivatives

Synthesis of Novel Fused Quinazolinone Derivatives Publisher Pubmed

Mahdavi M¹ ; Lotfi V² ; Saeedi M^{3, 4} ; Kianmehr E² ; Shafiee A⁵

Show Affiliations

1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran
3. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Molecular Diversity Published:2016

Abstract

Abstract: A four-step synthetic route was developed for the synthesis of novel fused quinazolinones, quinazolino[3,4-a]quinazolinones, and isoinodolo[2,1-a]quinazolino[1,2-c]quinazolineones. Reaction of isatoic anhydride and different amines gave various 2-aminobenzamides. Then, reaction of 2-aminobenzamides with 2-nitrobenzaldehyde followed by the reduction of nitro group afforded 2-(2-aminophenyl)-3-aryl-2,3-dihydroquinazolin-4(1H)-one derivatives. Finally, reaction of the latter compounds with aromatic aldehydes or 2-formylbenzoic acid led to the formation of the corresponding products. Graphical Abstract: [Figure not available: see fulltext.] © 2016, Springer International Publishing Switzerland.

2. Combined Isocyanide-Based Multi-Component Ullmann-Type Reaction: An Efficient Access to Novel Nitrogen-Containing Pentacyclic Compounds, Molecular Diversity (2015)

3. A Green and Efficient Synthesis of 2-Thioxoquinazolinone Derivatives in Water Using Potassium Thiocyanate, Journal of Sulfur Chemistry (2017)

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5. An Efficient Four-Step Approach Toward Fused Triazino[1,6-A] Quinazolines, Combinatorial Chemistry and High Throughput Screening (2016)

6. Synthesis, Molecular Docking, and Cytotoxicity of Quinazolinone and Dihydroquinazolinone Derivatives As Cytotoxic Agents, BMC Chemistry (2022)

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Mohammad Mahdavi (6)

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Style	Citing Format
MLA	Mahdavi M, et al.. "Synthesis of Novel Fused Quinazolinone Derivatives." Molecular Diversity, vol. 20, no. 3, 2016, pp. 677-685.
APA	Mahdavi M, Lotfi V, Saeedi M, Kianmehr E, Shafiee A (2016). Synthesis of Novel Fused Quinazolinone Derivatives. Molecular Diversity, 20(3), 677-685.
Chicago	Mahdavi M, Lotfi V, Saeedi M, Kianmehr E, Shafiee A. "Synthesis of Novel Fused Quinazolinone Derivatives." Molecular Diversity 20, no. 3 (2016): 677-685.
Harvard	Mahdavi M et al. (2016) 'Synthesis of Novel Fused Quinazolinone Derivatives', Molecular Diversity, 20(3), pp. 677-685.
Vancouver	Mahdavi M, Lotfi V, Saeedi M, Kianmehr E, Shafiee A. Synthesis of Novel Fused Quinazolinone Derivatives. Molecular Diversity. 2016;20(3):677-685.
BibTex	@article{ author = {Mahdavi M and Lotfi V and Saeedi M and Kianmehr E and Shafiee A}, title = {Synthesis of Novel Fused Quinazolinone Derivatives}, journal = {Molecular Diversity}, volume = {20}, number = {3}, pages = {677-685}, year = {2016} }
RIS	TY - JOUR AU - Mahdavi M AU - Lotfi V AU - Saeedi M AU - Kianmehr E AU - Shafiee A TI - Synthesis of Novel Fused Quinazolinone Derivatives JO - Molecular Diversity VL - 20 IS - 3 SP - 677 EP - 685 PY - 2016 ER -

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