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Solubility of Caffeine in Carbitol + Ethanol Mixture at Different Temperatures Publisher



Rezaei H1, 2 ; Rahimpour E2, 3 ; Martinez F4 ; Jouyban A2, 5
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia – Sede Bogota, Cra. 30 No. 45-03, Bogota, D.C., Colombia
  5. 5. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

The solubility of caffeine in non-aqueous mixed solutions of carbitol and ethanol at different temperatures are determined by a shake-flask method and fitted to some reported cosolvency models including the van't Hoff, the double log-log, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the modified Wilson models. Along with solubility, the densities of caffeine saturated mixtures are also measured and correlated with the Jouyban-Acree model. In order to study the accuracy of the employed models, the mean relative deviations (MRD%) of the back-calculated solubility and density data are calculated. Furthermore, the apparent thermodynamic properties of caffeine dissolution process in the mixed solutions of carbitol and ethanol are also calculated by using van't Hoff and Gibbs equations. © 2020 Elsevier B.V.
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