Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the A Review of Fixed-Dose Combination Therapy for Secondary Prevention of Adverse Cardiovascular Events and the Preliminary Results of the Persianpolypill Randomized Clinical Trial; [کارآزمایی بالینی تصادفی Persianpolypill شدهی مروری بر درمان ترکیبی با دوز ثابت برای پیشگیری ثانویه از حوادث نامطلوب قلبی- عروقی و نتایج اولیهی]
Valiollah Hajhashemi
Valiollah Hajhashemi

Professor of Pharmacology

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences

Pharmaceutical Sciences Research Center

Isfahan University of Medical Sciences

All Documents
1. A Comparison of the Effects of Chlorhexidine and Sodium Bicarbonate Mouthwashes on Covid-19-Related Symptoms, Iranian Journal of Nursing and Midwifery Research (2024)
2. Anti-Inflammatory and Antinociceptive Effects of Sitagliptin in Animal Models and Possible Mechanisms Involved in the Antinociceptive Activity, Korean Journal of Pain (2024)
3. Antinociceptive Effect of Artemisia Dracunculus Essential Oil in Formalin Test and Possible Involvement of Serotoninergic Receptors and Nitric Oxide Pathway, Research Journal of Pharmacognosy (2024)
4. Development of the First Iranian Clinical Practice Guidelines for the Diagnosis, Treatment, and Secondary Prevention of Acute Coronary Syndrome, Journal of Research in Medical Sciences (2024)
5. Development of the First Iranian Clinical Practice Guidelines for the Diagnosis, Treatment, and Secondary Prevention of Acute Coronary Syndrome, Journal of Research in Medical Sciences (2024)
6. First Iranian Guidelines for the Diagnosis, Management, and Treatment of Hyperlipidemia in Adults, Journal of Research in Medical Sciences (2024)
7. First Iranian Guidelines for the Diagnosis, Management, and Treatment of Hyperlipidemia in Adults, Journal of Research in Medical Sciences (2024)
8. Gabapentin Prevented Depressive Behavior Initiated by Dexamethasone, Stress or Inflammation in Mice, Bulletin of Pharmaceutical Sciences. Assiut (2024)
9. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats, International Journal of Preventive Medicine (2024)
10. Preparation and Evaluation of Hair Growth Promoting Effect of Transferosomes Containing Red Clover Extract and Caffeine Alone or in Combination, Avicenna Journal of Phytomedicine (2024)
11. Evaluation of the Effectiveness of Topical Oily Solution Containing Frankincense Extract in the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, BMC Research Notes (2023)
12. Involvement of the No/Cgmp/Katppathway in the Antinociceptive Effect of Rosemary (Rosmarinus Officinalis) Essential Oil in Mice, Behavioural Pharmacology (2023)
13. Lavender Essential Oil Improved Depressive Behavior in Mice After Interferon-Α Administration But Not After Cyclosporine a Administration, Bulletin of Pharmaceutical Sciences. Assiut (2023)
14. Smart Redox-Sensitive Micelles Based on Chitosan for Dasatinib Delivery in Suppressing Inflammatory Diseases, International Journal of Biological Macromolecules (2023)
15. Evaluation of the Antinociceptive Effects of a Selection of Triazine Derivatives in Mice, Korean Journal of Pain (2022)
16. Vanillic Acid Prevents Interferon-Alpha and Cyclosporine A-Induced Depressant-Like Behavior in Mice, Journal of Reports in Pharmaceutical Sciences (2022)
17. Anti-Nociceptive and Anti-Inflammatory Effects of Hydroalcoholic Extract and Essential Oil of Pinus Eldarica in Animal Models, Avicenna Journal of Phytomedicine (2021)
18. Creatine and Α-Lipoic Acid Improved Dexamethasone-Induced Depressive-Like Behavioral Parameters in Mice, Hacettepe University Journal of the Faculty of Pharmacy (2021)
19. Design, Synthesis, Biological Evaluation, and Molecular Docking Study on Triazine Based Derivatives As Anti-Inflammatory Agents, Journal of Molecular Structure (2021)
20. Effect of a Selection of Skin Penetration Enhancers on Topical Anti-Inflammatory Effect of Boswellic Acids in Carrageenan-Induced Paw Edema in Rats, Advanced Biomedical Research (2021)
21. Preparation and Evaluation of Imatinib Loaded Transfersomal Gel for the Treatment of Rheumatoid Arthritis, Iranian Journal of Pharmaceutical Research (2021)
22. Synthesis and Anti-Inflammatory Effects Evaluation of 1,3 Substituted Isatin Derivatives, Thai Journal of Pharmaceutical Sciences (2021)
23. A Synbiotic Mixture Augmented the Efficacy of Doxepin, Venlafaxine, and Fluvoxamine in a Mouse Model of Depression; [Sinbiyotik Karisim, Fare Depresyon Modelinde Doksepin, Venlafaksin Ve Fluvoksaminin Etkinligini Artirdi], Turkish Journal of Pharmaceutical Sciences (2020)
24. Anti-Nociceptive and Anti-Inflammatory Effects of Ferulago Angulata, Immunopathologia Persa (2020)
25. Antiobesity Effects of Seedlac and Shellac in Rats Fed With a High-Fat Diet, Research in Pharmaceutical Sciences (2020)
26. Antiobesity Effects of Seedlac and Shellac in Rats Fed With a High-Fat Diet, Research in Pharmaceutical Sciences (2020)
27. Celecoxib, Ibuprofen, and Indomethacin Alleviate Depression-Like Behavior Induced by Interferon-Alfa in Mice, Journal of Complementary and Integrative Medicine (2020)
28. Cycloarta-23-Ene-3Beta,25-Diol a Pentacyclic Steroid From Euphorbia Spinidens, As Cox Inhibitor With Molecular Docking, and in Vivo Study of Its Analgesic and Anti-Inflammatory Activities in Male Swiss Mice and Wistar Rats, Prostaglandins and Other Lipid Mediators (2020)
29. Dextromethorphan Improved Cyclosporine-Induced Depression in Mice Model of Despair, Research in Pharmaceutical Sciences (2020)
30. Ortho-Vanillin Nanoparticle-Doped Glucan Microspheres Exacerbate the Anti-Arthritic Effects of Methotrexate in Adjuvant-Induced Arthritis In Rats, Pharmacological Reports (2020)
31. Quality of Life Among Patients With Multiple Sclerosis and Voiding Dysfunction: A Cross-Sectional Study, BMC Urology (2020)
32. Sexual Dysfunction in Women With Multiple Sclerosis: Prevalence and Impact on Quality of Life, BMC Urology (2020)
33. The Prevalence of Lower Urinary Tract Symptoms Based on Individual and Clinical Parameters in Patients With Multiple Sclerosis, BMC Neurology (2020)
34. Antidepressant-Like Effect of Minocycline in Mice Forced Swimming Test: Minor Involvement of the Noradrenergic System, Thai Journal of Pharmaceutical Sciences (2019)
35. Antidepressant-Like Effect of Vitamin B6 in Mice Forced Swimming Test and the Possible Involvement of the Noradrenergic System, Journal of Reports in Pharmaceutical Sciences (2019)
36. Maprotiline Inhibits Cox2 and Inos Gene Expression in Lipopolysaccharide-Stimulated U937 Macrophages and Carrageenan-Induced Paw Edema in Rats, Central European Journal of Immunology (2019)
37. Monosodium Glutamate Influences Depressive Behavior of Two Age Groups of Mice in Forced Swimming Test: Vitamin B6 Could Remedy the Situation, Personalized Medicine in Psychiatry (2019)
38. N-Methyl-D-Aspartate Receptor Antagonists Decrease Interferon-Alpha Induced Depressive Behavior in Mice Model of Despair, Thai Journal of Pharmaceutical Sciences (2019)
39. Protective Effect of Dizocilpine (Mk-801) on Tnbs-Induced Experimental Colitis in Mice, Iranian Journal of Pharmaceutical Research (2019)
40. The Effect of Lead, Restraint Stress or Their Co-Exposure on the Movement Disorders Incidence in Male Mice, Research in Pharmaceutical Sciences (2019)
41. The Effect of Vitamin B6 on Dexamethasone-Induced Depression in Mice Model of Despair, Nutritional Neuroscience (2019)
42. Antihypertensive and Antioxidant Effects of Protocatechuic Acid in Deoxycorticosterone Acetate-Salt Hypertensive Rats, Biomedicine and Pharmacotherapy (2018)
43. Evaluating the Effect of Donepezil on Depression and Obsessive–Compulsion Disorder in Mice Models and Proposing the Mechanism Involved, Thai Journal of Pharmaceutical Sciences (2018)
44. The Effect of Celecoxib on Blood Pressure and Plasma Oxidant/Antioxidant Status in Co-Administration With Glucocorticoid in Rat, Biomedicine and Pharmacotherapy (2018)
45. Effect of Concomitant Administration of Three Different Antidepressants With Vitamin B6 on Depression and Obsessive Compulsive Disorder in Mice Models, Research in Pharmaceutical Sciences (2017)
46. Effect of Scopolamine and Mecamylamine on Antidepressant Effect of Rivastigmine in a Behavioral Despair Test in Mice, Journal of Reports in Pharmaceutical Sciences (2017)
47. Evaluation of Central and Peripheral Effects of Doxepin on Acetic Acid-Induced Colitis in Rat and the Involved Mechanisms, EXCLI Journal (2017)
48. Evaluation of the Central and Peripheral Effects of Doxepin on Carrageenan-Induced Inflammatory Paw Edema in Rat, Research in Pharmaceutical Sciences (2017)
49. Evaluation of the Effect of Elaeagnus Angustifolia Alone and Combined With Boswellia Thurifera Compared With Ibuprofen in Patients With Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial, Clinical Rheumatology (2017)
50. In Vitro and in Vivo Modulation of Lps and Carrageenan-Induced Expression of Inflammatory Genes by Amitriptyline, Journal of Pharmacy and Pharmacognosy Research (2017)
51. Protective Effects of Coenzyme Q10 and L-Carnitine Against Statin-Induced Pancreatic Mitochondrial Toxicity in Rats, Research in Pharmaceutical Sciences (2017)
52. Toxicity of Atorvastatin on Pancreas Mitochondria: A Justification for Increased Risk of Diabetes Mellitus, Basic and Clinical Pharmacology and Toxicology (2017)
53. A Comparison of the Effect of Certain Inorganic Salts on Suppression Acute Skin Irritation by Human Biometric Assay: A Randomized, Double-Blind Clinical Trial, Journal of Research in Medical Sciences (2016)
54. Anti-Inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats, Iranian Journal of Pharmaceutical Research (2016)
55. Biomimetic Proopiomelanocortin Suppresses Capsaicin-Induced Sensory Irritation in Humans, Research in Pharmaceutical Sciences (2016)
56. Effect of Intravenous Midazolam on Cardiac Parameters in Acute Tricyclic Antidepressants Poisoning, ARYA Atherosclerosis (2016)
57. Fluvoxamine Inhibits Some Inflammatory Genes Expression in Lps/Stimulated Human Endothelial Cells, U937 Macrophages, and Carrageenan-Induced Paw Edema in Rat, Iranian Journal of Basic Medical Sciences (2016)
58. Maprotiline Inhibits Lps-Induced Expression of Adhesion Molecules (Icam-1 and Vcam-1) in Human Endothelial Cells, Research in Pharmaceutical Sciences (2016)
59. Simultaneous Detection of Morphine and Codeine in Urine Samples of Heroin Addicts Using Multi-Walled Carbon Nanotubes Modified Sno 2 -Zn 2 Sno 4 Nanocomposites Paste Electrode, Applied Surface Science (2016)
60. The Effect of Memantine on Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis in Mice, European Journal of Pharmacology (2016)
61. The Effect of Protocatechuic Acid on Blood Pressure and Oxidative Stress in Glucocorticoid-Induced Hypertension in Rat, Iranian Journal of Pharmaceutical Research (2016)
62. Antinociceptive Effects of Maprotiline in a Rat Model of Peripheral Neuropathic Pain: Possible Involvement of Opioid System, Iranian Journal of Basic Medical Sciences (2015)
63. Effect of Venlafaxine on Experimental Colitis in Normal and Reserpinised Depressed Rats, Research in Pharmaceutical Sciences (2015)
64. Evaluation of Anti-Colitic Effect of Fluvoxamine Against Acetic Acid-Induced Colitis in Normal and Reserpinized Depressed Rats, European Journal of Pharmacology (2015)
65. Hypnotic Effect of Coriandrum Sativum, Ziziphus Jujuba, Lavandula Angustifolia and Melissa Officinalis Extracts in Mice, Research in Pharmaceutical Sciences (2015)
66. Minocycline Potentiates the Anti-Hyperalgesic Effect of Ceftriaxone in Cci-Induced Neuropathic Pain in Rats, Research in Pharmaceutical Sciences (2015)
67. Systemic Effects of Fluoxetine on the Amount of Tooth Movement, Root Resorption, and Alveolar Bone Remodeling During Orthodontic Force Application in Rat, Dental Research Journal (2015)
68. The Anti-Inflammatory Effects of Venlafaxine in the Rat Model of Carrageenan-Induced Paw Edema, Iranian Journal of Basic Medical Sciences (2015)
69. Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy, Iranian Journal of Pharmaceutical Research (2015)
70. Analgesic and Anti-Inflammatory Activities of Bupropion in Animal Models, Research in Pharmaceutical Sciences (2014)
71. Antinociceptive Effect of Clavulanic Acid and Its Preventive Activity Against Development of Morphine Tolerance and Dependence in Animal Models, Research in Pharmaceutical Sciences (2014)
72. Antinociceptive Effects of Venlafaxine in a Rat Model of Peripheral Neuropathy: Role of Alpha2-Adrenergic Receptors, European Journal of Pharmacology (2014)
73. Ceftriaxone, a Beta-Lactam Antibiotic, Modulates Apoptosis Pathways and Oxidative Stress in a Rat Model of Neuropathic Pain, BioMed Research International (2014)
74. The Effect of Nimodipine on Memory Loss Following Naloxone-Induced Morphine Withdrawal in Object Recognition, Research in Pharmaceutical Sciences (2014)
75. The Effects of Local Injection of Simvastatin on Tooth Movement and Root Resorption Rates Under Orthodontic Forces in Dogs, Biosciences Biotechnology Research Asia (2014)
76. Antiallodynia and Antihyperalgesia Effects of Ceftriaxone in Treatment of Chronic Neuropathic Pain in Rats, Acta Neuropsychiatrica (2013)
77. Evaluation of the Effect of Aromatherapy With Lavender Essential Oil on Post-Tonsillectomy Pain in Pediatric Patients: A Randomized Controlled Trial, International Journal of Pediatric Otorhinolaryngology (2013)
78. Further Studies on Anti-Inflammatory Activity of Maprotiline in Carrageenan-Induced Paw Edema in Rat, International Immunopharmacology (2013)
79. Protective Effects of the Morus Alba L. Leaf Extracts on Cisplatininduced Nephrotoxicity in Rat, Research in Pharmaceutical Sciences (2013)
80. The Effect of Am281, a Cannabinoid Antagonist, on Memory Performance During Spontaneous Morphine Withdrawal in Mice, Research in Pharmaceutical Sciences (2013)
81. A Study on the Analgesic Effects of Four New Derivatives of 3-Hydroxy Pyridine-4-One, Research in Pharmaceutical Sciences (2012)
82. Am281, Cannabinoid Antagonist/Inverse Agonist, Ameliorates Scopolamine-Induced Cognitive Deficit, Iranian Journal of Basic Medical Sciences (2012)
83. Anti-Inflammatory and Wound Healing Activities of Aloe Littoralis in Rats, Research in Pharmaceutical Sciences (2012)
84. Antinociceptive and Anti-Inflammatory Activities of Satureja Hortensis Seed Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models, Medical Principles and Practice (2012)
85. Antinociceptive Evaluation of Ceftriaxone and Minocycline Alone and in Combination in a Neuropathic Pain Model in Rat, Neuroscience (2012)
86. Co-Administration of Calcium Gluconate and Magnesium Acetate Effectively Blocks the Signs of Morphine Withdrawal in Mice, Magnesium Research (2012)
87. Effects of the Persian Carum Copticum Fruit Extracts on Morphine Withdrawal Syndrome in Mice, Research in Pharmaceutical Sciences (2012)
88. The Cb1 Receptor Antagonist, Am281, Improves Recognition Loss Induced by Naloxone in Morphine Withdrawal Mice, Basic and Clinical Pharmacology and Toxicology (2012)
89. The Effect of Nimodipine on Memory Impairment During Spontaneous Morphine Withdrawal in Mice: Corticosterone Interaction, European Journal of Pharmacology (2012)
90. A Study on the Mechanisms Involving the Anti-Inflammatory Effect of Amitriptyline in Carrageenan-Induced Paw Edema in Rats, European Journal of Pharmacology (2011)
91. Antinociceptive and Anti-Inflammatory Activities of Bunium Persicum Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models, Pharmaceutical Biology (2011)
92. Antinociceptive Study of Extracts of Platanus Orientalis Leaves in Mice, Research in Pharmaceutical Sciences (2011)
93. Effect of Fluvoxamine on Carrageenan-Induced Paw Edema in Rats Evaluation of the Action Sites, Iranian Journal of Pharmaceutical Research (2011)
94. Effect of Glibenclamide on Antinociceptive Effects of Antidepressants of Different Classes, Clinics (2011)
95. Pharmacokinetic Study of Niosome-Loaded Insulin in Diabetic Rats, DARU, Journal of Pharmaceutical Sciences (2011)
96. Analgesic and Anti-Infammatory Effects of Rosa Damascena Hydroalcoholic Extract and Its Essential Oil in Animal Models, Iranian Journal of Pharmaceutical Research (2010)
97. Are Antioxidants Helpful for Disease Prevention?, Research in Pharmaceutical Sciences (2010)
98. Central and Peripheral Anti-Inflammatory Effects of Maprotiline on Carrageenan-Induced Paw Edema in Rats, Inflammation Research (2010)
99. Evaluation of Antianxiety and Sedative Effects of Essential Oil of Ducrosia Anethifolia in Mice, Clinics (2010)
100. The Role of Central Mechanisms in the Anti-Inflammatory Effect of Amitriptyline on Carrageenan-Induced Paw Edema in Rats, Clinics (2010)
101. Anti-Inflammatory and Analgesic Properties of Heracleum Persicum Essential Oil and Hydroalcoholic Extract in Animal Models, Journal of Ethnopharmacology (2009)
102. Increase in Brain Corticosterone Concentration and Recognition Memory Impairment Following Morphine Withdrawal in Mice, Stress (2009)
103. Hypolipidemic Activity of Anethum Graveolens in Rats, Phytotherapy Research (2008)
104. Metyrapone and Mifepristone Reverse Recognition Memory Loss Induced by Spontaneous Morphine Withdrawal in Mice, Basic and Clinical Pharmacology and Toxicology (2008)
105. Effect of Tizanidine, Rilmenidine, and Yohimbine on Naloxon-Induced Morphine Withdrawal Syndrome in Mice, Iranian Journal of Pharmaceutical Research (2007)
106. The Effect of 2,3-Dihydroxybenzoic Acid and Tempol in Prevention of Vancomycin-Induced Nephrotoxicity in Rats, Toxicology (2007)
107. Vancomycin-Induced Nephrotoxicity in Rats: Is Enzyme Elevation a Consistent Finding in Tubular Injury?, Journal of Nephrology (2007)
108. Evaluation of Cardiovascular Effect of Pycnocycla Spinosa Decne. Exboiss. Var. Spinosa Extract in Anaesthetized Rat, Daru (2006)
109. An Investigation of the Analgesic and Anti-Inflammatory Effects of Nigella Sativa Seed Polyphenols, Journal of Medicinal Food (2005)
110. Black Cumin Seed Essential Oil, As a Potent Analgesic and Antiinflammatory Drug, Phytotherapy Research (2004)
111. Effects of Otostegia Persica (Burm.) Boiss on Morphine Withdrawal Syndrome in Mice, Iranian Journal of Pharmaceutical Research (2004)
112. Anti-Inflammatory and Analgesic Properties of the Leaf Extracts and Essential Oil of Lavandula Angustifolia Mill., Journal of Ethnopharmacology (2003)
113. Development and Physical Characterization of Sorbitan Monoester Niosomes for Insulin Oral Delivery, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2003)
114. Antinociceptive and Anti-Inflammatory Effects of Satureja Hortensis L. Extracts and Essential Oil, Journal of Ethnopharmacology (2002)
115. Effects of Long-Term Phenytoin or Phenytoin Plus Ascorbic Acid Administration on Urethane Anesthetic Effect in Rats: A Controlled Study, Current Therapeutic Research - Clinical and Experimental (2002)
116. Involvement of Calmodulin Inhibition in Analgesia Induced With Low Doses of Intrathecal Trifluoperazine, Japanese Journal of Pharmacology (2002)
117. Spasmolytic Activity of Essential Oil and Various Extracts of Ferula Gummosa Boiss. on Ileum Contractions, Phytomedicine (2001)