Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the In Silico Identification of Natural Products and World-Approved Drugs Targeting the Keap1/Nrf2 Pathway Endowed With Potential Antioxidant Profile
Ziba Rajaei
Ziba Rajaei

Professor of Physiology

Department of Physiology, School of Medicine

Isfahan University of Medical Sciences

All Documents
1. Gallic Acid Ameliorates Lps-Induced Memory Decline by Modulating Nf-Κb, Tnf-Α, and Caspase 3 Gene Expression and Attenuating Oxidative Stress and Neuronal Loss in the Rat Hippocampus, Metabolic Brain Disease (2025)
2. Crocin Improves Cognitive Impairment in Lps-Treated Rats Through Anti-Apoptotic, Anti-Inflammatory, and Antioxidant Activities, Molecular Neurobiology (2024)
3. Effects of Berberis Vulgaris Fruit Extract on Oxidative Stress Status in the Kidney and Liver of Diabetic Rats, Journal of Complementary and Integrative Medicine (2024)
4. Neuroprotective Effects of Sesamol Against Lps-Induced Spatial Learning and Memory Deficits Are Mediated Via Anti-Inflammatory and Antioxidant Activities in the Rat Brain, Avicenna Journal of Phytomedicine (2023)
5. Treadmill Running and Levisticum Officinale Extract Protect Against Lps-Induced Memory Deficits by Modulating Neurogenesis, Neuroinflammation and Oxidative Stress, Metabolic Brain Disease (2023)
6. Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats, Advanced Biomedical Research (2022)
7. The Impact of Sesamol and Exercise on Striatal Tnf-Α Level, Motor Behavior, Aversive Memory and Oxidative Stress Status in 6-Hydroxydopamine-Lesioned Rats, Physiology and Pharmacology (Iran) (2022)
8. Effects of Crocin on Spatial or Aversive Learning and Memory Impairments Induced by Lipopolysaccharide in Rats, Avicenna Journal of Phytomedicine (2021)
9. Neuroprotective Effects of Levisticum Officinale on Lps-Induced Spatial Learning and Memory Impairments Through Neurotrophic, Anti-Inflammatory, and Antioxidant Properties, Food and Function (2020)
10. The Effects of Concurrent Treatment of Silymarin and Lactulose on Memory Changes in Cirrhotic Male Rats, BioImpacts (2020)
11. Effects of Carvacrol and Physical Exercise on Motor and Memory Impairments Associated With Parkinson’S Disease; [Efeitos Do Carvacrol E Do Exercicio Fisico Sobre O Comprometimento Motor E De Memoria Associados a Doenca De Parkinson], Arquivos de Neuro-Psiquiatria (2019)
12. Effects of Carvacrol on Spatial Learning Performances, Hippocampal Interleukin-1ß Level and Oxidative Stress Markers in Lipopolysaccharide-Treated Rats, Physiology and Pharmacology (Iran) (2019)
13. Pretreatment With Crocin Along With Treadmill Exercise Ameliorates Motor and Memory Deficits in Hemiparkinsonian Rats by Anti-Inflammatory and Antioxidant Mechanisms, Metabolic Brain Disease (2019)
14. Chronic Treatment With Carvacrol Improves Passive Avoidance Memory in a Rat Model of Parkinson’S Disease; [O Tratamento Com Carvacrol Melhora a Memoria De Esquiva Passiva Em Um Modelo Da Doenca De Parkinson Em Ratos], Arquivos de Neuro-Psiquiatria (2018)
15. Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats, Neuroscience Letters (2017)
16. Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis], Arquivos de Neuro-Psiquiatria (2017)
17. Effects of Lactulose and Silymarin on Liver Enzymes in Cirrhotic Rats, Canadian Journal of Physiology and Pharmacology (2017)
18. Effects of Aqueous-Ethanolic Extract of Nigella Sativa Seeds (Black Cumin) and Vitamin E on Cisplatin-Induced Nephrotoxicity in Rat, Research Journal of Medicinal Plant (2016)
19. Effects of Crocin on Brain Oxidative Damage and Aversive Memory in a 6-Ohda Model of Parkinson’S Disease; [Efeitos Da Crocina No Dano Oxidativo Cerebral E Na Memoria Aversiva Em Um Modelo 6-Ohda De Doenca De Parkinson], Arquivos de Neuro-Psiquiatria (2016)
20. The Effects of Crocin on 6-Ohda-Induced Oxidative/Nitrosative Damage and Motor Behaviour in Hemiparkinsonian Rats, Malaysian Journal of Medical Sciences (2016)
21. Effects of Crocin on Rotational Behavior, Lipid Peroxidation and Nitrite Levels in Rat’S Brain Striatum in an Experimental Model of Parkinson's Disease, Journal of Isfahan Medical School (2015)
22. Effects of Hydroalcoholic Extract of Watercress (Nasturtium Officinale) Leaves on Serum Glucose and Lipid Levels in Diabetic Rats, Indian Journal of Physiology and Pharmacology (2015)
23. Effects of Fenugreek Seeds on Adipogenesis and Lipolysis in Normal and Diabetic Rats, Pakistan Journal of Biological Sciences (2014)
24. Effects of Securigera Securidaca Extract on Lipolysis and Adipogenesis in Diabetic Rats, Cholesterol (2014)
25. The Role of Local Renin-Angiotensin System on High Glucose-Induced Cell Toxicity, Apoptosis and Reactive Oxygen Species Production in Pc12 Cells, Iranian Journal of Basic Medical Sciences (2014)
26. Antihyperglycemic and Antioxidant Activity of Crocin in Streptozotocin-Induced Diabetic Rats, Journal of Medicinal Food (2013)
27. Brain Tissue Oxidative Damage As a Possible Mechanism for the Deleterious Effect of a Chronic High Dose of Estradiol on Learning and Memory in Ovariectomized Rats; [Dano Oxidativo Ao Tecido Cerebral Como Possivel Mecanismo De Efeito Deleterio Da Alta Dose Cronica De Estradiol No Aprendizado E Memoria De Ratas Ooforectomizadas], Arquivos de Neuro-Psiquiatria (2013)
28. Effect of Aqueous Extract of Rheum Ribes on Cisplatin-Induced Nephrotoxicity in Rat, Journal of Pharmacy and Bioallied Sciences (2013)
29. Ascorbate Reduces Morphine-Induced Extracellular Dopac Level in the Nucleus Accumbens: A Microdialysis Study in Rats, Brain Research (2005)