Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Design and Synthesis of Novel Nitrothiazolacetamide Conjugated to Different Thioquinazolinone Derivatives As Anti-Urease Agents
Mahmood Biglar
Mahmood Biglar

Assistant Professor of Medicinal Chemistry

Drug Design and Development Research Center

Tehran University of Medical Sciences

Related Documents
1. Design and Synthesis of Novel Nitrothiazolacetamide Conjugated to Different Thioquinazolinone Derivatives As Anti-Urease Agents, Scientific Reports (2022)
2. Novel Phenylurea-Pyridinium Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro, and in Silico Studies, Journal of Molecular Structure (2022)
3. New Thioxothiazolidinyl-Acetamides Derivatives As Potent Urease Inhibitors: Design, Synthesis, in Vitro Inhibition, and Molecular Dynamic Simulation, Scientific Reports (2023)
4. Synthesis and in Vitro Urease Inhibitory Activity of 5-Nitrofuran-2-Yl-Thiadiazole Linked to Different Cyclohexyl-2-(Phenylamino)Acetamides, in Silico and Kinetic Studies, Bioorganic Chemistry (2022)
5. Design, Synthesis, Docking Study and Urease Inhibitory Activity Evaluation of Novel 2-((5-Amino-1,3,4-Thiadiazol-2-Yl)Thio)-N-Arylacetamide Derivatives, Medicinal Chemistry Research (2021)
6. Synthesis, Biological Evaluation and Molecular Docking of Deferasirox and Substituted 1,2,4-Triazole Derivatives As Novel Potent Urease Inhibitors: Proposing Repositioning Candidate, Chemistry and Biodiversity (2020)
7. Design, Synthesis, and Evaluation of Metronidazole-1,2,3-Triazole Derivatives As Potent Urease Inhibitors, Chemical Papers (2021)
8. Different Barbiturate Derivatives Linked to Aryl Hydrazone Moieties As Urease Inhibitors; Design, Synthesis, Urease Inhibitory Evaluations, and Molecular Dynamic Simulations, Medicinal Chemistry Research (2023)
9. Isoindolin-1-Ones Fused to Barbiturates: From Design and Molecular Docking to Synthesis and Urease Inhibitory Evaluation, ACS Omega (2022)
10. Design and Synthesis of New N-Thioacylated Ciprofloxacin Derivatives As Urease Inhibitors With Potential Antibacterial Activity, Scientific Reports (2022)
11. Rational Design, Synthesis, in Vitro, and in Silico Studies of Chlorophenylquinazolin-4(3H)-One Containing Different Aryl Acetohydrazides As Tyrosinase Inhibitors, Chemistry and Biodiversity (2022)
12. Novel (Thio)Barbituric-Phenoxy-N-Phenylacetamide Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro Urease Inhibition, and in Silico Evaluations, Structural Chemistry (2021)
13. Novel N,N-Dimethylbarbituric-Pyridinium Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro, and in Silico Studies, Bioorganic Chemistry (2020)
All Documents
1. Design, Synthesis, and Investigation of Novel 5-Arylpyrazole-Glucose Hybrids As Α-Glucosidase Inhibitors, Scientific Reports (2025)
2. Synthesis and Molecular Docking Studies of New Aryl Imeglimin Derivatives As a Potent Antidiabetic Agent in a Diabetic Zebrafish Model, Scientific Reports (2024)
3. Advancement of Organoid Technology in Regenerative Medicine, Regenerative Engineering and Translational Medicine (2023)
4. Different Barbiturate Derivatives Linked to Aryl Hydrazone Moieties As Urease Inhibitors; Design, Synthesis, Urease Inhibitory Evaluations, and Molecular Dynamic Simulations, Medicinal Chemistry Research (2023)
5. How to Establish Infrastructures to Achieve More Efficient Regenerative Medicine?, Cell and Tissue Banking (2023)
6. In Silico Analysis of Neutralizing Antibody Epitopes on the Hepatitis C Virus Surface Glycoproteins, Cell Journal (2023)
7. New Thioxothiazolidinyl-Acetamides Derivatives As Potent Urease Inhibitors: Design, Synthesis, in Vitro Inhibition, and Molecular Dynamic Simulation, Scientific Reports (2023)
8. Aminoimidazo[1,2-A]Pyridine Bearing Different Pyrazole Moieties As the Structural Scaffold for the Development of Bace1 Inhibitor; Synthesis, Structural Characterization, in Vitro and in Silico Studies, Current Organic Synthesis (2022)
9. An Overview of Zebrafish Modeling Methods in Drug Discovery and Development, Advances in Experimental Medicine and Biology (2022)
10. Assessing the Maturity of Intellectual Capital in the Field of Management and Planning of Tehran University of Medical Sciences, Journal of Payavard Salamat (2022)
11. Association of Talent Management on Employees’ Empowerment and Human Resource Productivity in Tehran University of Medical Sciences, Payesh (2022)
12. Cyanuric Chloride Mediated One-Pot Three-Component Reaction of Benzoylhydrazinyl-N-Alkyl Acetamide Derivatives As a New Urease Inhibitor Scaffold: Docking Study and Enzyme Inhibitory Activity, Pharmaceutical Chemistry Journal (2022)
13. Design and Synthesis of New N-Thioacylated Ciprofloxacin Derivatives As Urease Inhibitors With Potential Antibacterial Activity, Scientific Reports (2022)
14. Design and Synthesis of Novel Nitrothiazolacetamide Conjugated to Different Thioquinazolinone Derivatives As Anti-Urease Agents, Scientific Reports (2022)
15. Design, Synthesis, in Vitro, and in Silico Enzymatic Evaluations of Thieno[2,3-B]Quinoline-Hydrazones As Novel Inhibitors for Α-Glucosidase, Bioorganic Chemistry (2022)
16. Isoindolin-1-Ones Fused to Barbiturates: From Design and Molecular Docking to Synthesis and Urease Inhibitory Evaluation, ACS Omega (2022)
17. New 4-Phenylpiperazine-Carbodithioate-N-Phenylacetamide Hybrids: Synthesis, in Vitro and in Silico Evaluations Against Cholinesterase and Α-Glucosidase Enzymes, Archiv der Pharmazie (2022)
18. Novel Aryl(4-Phenylpiperazin-1-Yl)Methanethione Derivatives As New Anti-Alzheimer Agents: Design, Synthesis, in Vitro and in Silico Assays, Journal of Molecular Structure (2022)
19. Novel Phenylurea-Pyridinium Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro, and in Silico Studies, Journal of Molecular Structure (2022)
20. Novel Quinazolin–Sulfonamid Derivatives: Synthesis, Characterization, Biological Evaluation, and Molecular Docking Studies, Journal of Biomolecular Structure and Dynamics (2022)
21. Rational Design, Synthesis, in Vitro, and in Silico Studies of Chlorophenylquinazolin-4(3H)-One Containing Different Aryl Acetohydrazides As Tyrosinase Inhibitors, Chemistry and Biodiversity (2022)
22. Synthesis and Evaluation of Anti-Epileptic Properties of New Phthalimide-4,5-Dihydrothiazole-Amide Derivatives, Polycyclic Aromatic Compounds (2022)
23. Synthesis and in Vitro Urease Inhibitory Activity of 5-Nitrofuran-2-Yl-Thiadiazole Linked to Different Cyclohexyl-2-(Phenylamino)Acetamides, in Silico and Kinetic Studies, Bioorganic Chemistry (2022)
24. Synthesis, Molecular Dynamic, and in Silico Study of New Ethyl 4-Arylpyrimido[1,2-B]Indazole-2-Carboxylate: Potential Inhibitors of Α-Glucosidase, Journal of Molecular Structure (2022)
25. Synthesis, Α-Glucosidase Inhibition, in Silico Pharmacokinetic, and Docking Studies of Thieno[2,3-B]Quinoline-Acetamide Derivatives As New Anti-Diabetic Agents, ChemistrySelect (2022)
26. Design and Synthesis of 4,5-Diphenyl-Imidazol-1,2,3-Triazole Hybrids As New Anti-Diabetic Agents: In Vitro Α-Glucosidase Inhibition, Kinetic and Docking Studies, Molecular Diversity (2021)
27. Design, Synthesis, and Evaluation of Metronidazole-1,2,3-Triazole Derivatives As Potent Urease Inhibitors, Chemical Papers (2021)
28. Design, Synthesis, and Α-Glucosidase-Inhibitory Activity of Phenoxy-Biscoumarin–N-Phenylacetamide Hybrids, Archiv der Pharmazie (2021)
29. Design, Synthesis, Docking Study and Urease Inhibitory Activity Evaluation of Novel 2-((5-Amino-1,3,4-Thiadiazol-2-Yl)Thio)-N-Arylacetamide Derivatives, Medicinal Chemistry Research (2021)
30. Design, Synthesis, in Vitro and in Silico Biological Assays of New Quinazolinone-2-Thio-Metronidazole Derivatives, Journal of Molecular Structure (2021)
31. Diabetes and Heart Failure: Multi-Omics Approaches, Frontiers in Physiology (2021)
32. Novel (Thio)Barbituric-Phenoxy-N-Phenylacetamide Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro Urease Inhibition, and in Silico Evaluations, Structural Chemistry (2021)
33. Novel Coumarin Containing Dithiocarbamate Derivatives As Potent Α-Glucosidase Inhibitors for Management of Type 2 Diabetes, Medicinal Chemistry (2021)
34. Recent Strategies in the Synthesis of Thiophene Derivatives: Highlights From the 2012–2020 Literature, Molecular Diversity (2021)
35. Screening and Identification of Herbal Urease Inhibitors Using Surface Plasmon Resonance Biosensor, Research Journal of Pharmacognosy (2021)
36. Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors, Journal of Biochemical and Molecular Toxicology (2021)
37. Α-Glucosidase and Α-Amylase Inhibition, Molecular Modeling and Pharmacokinetic Studies of New Quinazolinone-1,2,3-Triazole-Acetamide Derivatives, Medicinal Chemistry Research (2021)
38. 2,4-Dioxochroman Moiety Linked to 1,2,3-Triazole Derivatives As Novel Α-Glucosidase Inhibitors: Synthesis, in Vitro Biological Evaluation, and Docking Study, Current Organic Chemistry (2020)
39. 4-Oxobenzo[D]1,2,3-Triazin-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: Design, Synthesis, in Vitro Evaluation, Molecular Modeling, and Molecular Dynamic Study, Structural Chemistry (2020)
40. Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies, Journal of the Chinese Chemical Society (2020)
41. Cell-Based Approaches Towards Treating Age-Related Macular Degeneration, Cell and Tissue Banking (2020)
42. Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies, Journal of the Chinese Chemical Society (2020)
43. Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives, Journal of Heterocyclic Chemistry (2020)
44. Design, Synthesis and Biological Evaluation of Novel Phthalimide-Schiff Base-Coumarin Hybrids As Potent Α-Glucosidase Inhibitors, Chemical Papers (2020)
45. Design, Synthesis, Biological Evaluation, and Docking Study of New Acridine-9-Carboxamide Linked to 1,2,3-Triazole Derivatives As Antidiabetic Agents Targeting Α-Glucosidase, Journal of Heterocyclic Chemistry (2020)
46. Discovery of Direct Inhibitor of Kras Oncogenic Protein by Natural Products: A Combination of Pharmacophore Search, Molecular Docking, and Molecular Dynamic Studies, Research in Pharmaceutical Sciences (2020)
47. Efficient One-Pot Synthesis of Novel 6′,9′-Dihydro-2H,7′H-Spiro[Pyrimidine-5,8′-[1,3]Dioxolo[4,5-F]Quinoline]-2,4,6(1H,3H)-Trione Derivatives Under Mild and “Green” Reaction Conditions, Journal of Heterocyclic Chemistry (2020)
48. New 1,2,3-Triazole–(Thio)Barbituric Acid Hybrids As Urease Inhibitors: Design, Synthesis, in Vitro Urease Inhibition, Docking Study, and Molecular Dynamic Simulation, Archiv der Pharmazie (2020)
49. New Acridine-9-Carboxamide Linked to 1,2,3-Triazole-N-Phenylacetamide Derivatives As Potent Α-Glucosidase Inhibitors: Design, Synthesis, in Vitro, and in Silico Biological Evaluations, Medicinal Chemistry Research (2020)
50. New Phthalimide-Benzamide-1,2,3-Triazole Hybrids; Design, Synthesis, Α-Glucosidase Inhibition Assay, and Docking Study, Medicinal Chemistry Research (2020)
51. Novel N,N-Dimethylbarbituric-Pyridinium Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro, and in Silico Studies, Bioorganic Chemistry (2020)
52. Recent Advances in Alkyne Hydroamination As a Powerful Tool for the Construction of C−N Bonds, Asian Journal of Organic Chemistry (2020)
53. Synthesis and Biological Evaluation of New Benzimidazole-1,2,3-Triazole Hybrids As Potential Α-Glucosidase Inhibitors, Bioorganic Chemistry (2020)
54. Synthesis, Biological Evaluation and Molecular Docking of Deferasirox and Substituted 1,2,4-Triazole Derivatives As Novel Potent Urease Inhibitors: Proposing Repositioning Candidate, Chemistry and Biodiversity (2020)
55. Synthesis, Characterization, Molecular Docking, and Biological Activities of Coumarin–1,2,3-Triazole-Acetamide Hybrid Derivatives, Archiv der Pharmazie (2020)
56. Synthesis, in Vivo and in Silico Studies of N-Aryl-4-(1,3-Dioxoisoindolin-2-Yl)Benzamides As an Anticonvulsant Agent, Pharmaceutical Sciences (2020)
57. Biscoumarin-1,2,3-Triazole Hybrids As Novel Anti-Diabetic Agents: Design, Synthesis, in Vitro Α-Glucosidase Inhibition, Kinetic, and Docking Studies, Bioorganic Chemistry (2019)
58. Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids As New Agents for Treatment of Alzheimer's Disease, Chemistry and Biodiversity (2019)
59. Evaluation of Angiotensin Converting Enzyme Inhibitors by Spr Biosensor and Theoretical Studies, Enzyme and Microbial Technology (2019)
60. Isatoic Anhydride: A Fascinating and Basic Molecule for the Synthesis of Substituted Quinazolinones and Benzo Di/Triazepines, Current Organic Chemistry (2019)
61. New Thiosemicarbazide-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors: Design, Synthesis, and Biological Evaluation, Journal of Molecular Structure (2019)
62. New Thiosemicarbazide-1,2,3-Triazole Hybrids As Potent Α-Glucosidase Inhibitors: Design, Synthesis, and Biological Evaluation, Journal of Molecular Structure (2019)
63. Novel Morpholine Containing Cinnamoyl Amides As Potent Tyrosinase Inhibitors, International Journal of Biological Macromolecules (2019)
64. Synthesis, Molecular Docking, and Antiepileptic Activity of Novel Phthalimide Derivatives Bearing Amino Acid Conjugated Anilines, Research in Pharmaceutical Sciences (2019)
65. Surface Plasmon Resonance Based Biosensor for Discovery of New Matrix Metalloproteinase-9 Inhibitors, Sensors and Actuators# B: Chemical (2018)