Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Production and Characterization of a Panel of Anti-Mouse Placenta-Specific Protein 1 (Plac1) Monoclonal Antibodies
Amirhasan Zarnani
Amirhasan Zarnani

Professor of Medical Immunology

Department Pathobiology

School of Public Health

Tehran University of Medical Sciences

Related Documents
1. Production and Characterization of a Panel of Anti-Mouse Placenta-Specific Protein 1 (Plac1) Monoclonal Antibodies, Analytical Biochemistry (2025)
2. Expression of Human Placenta-Specific 1 (Plac1) in Cho-K1 Cells, Avicenna Journal of Medical Biotechnology (2020)
3. Optimization of Expression and Purification of Recombinant Mouse Plac1, Avicenna Journal of Medical Biotechnology (2021)
4. Plac1: Biology and Potential Application in Cancer Immunotherapy, Cancer Immunology# Immunotherapy (2019)
5. Expression Profiling of Plac1 in Murine Cancer Cell Lines, Experimental Oncology (2019)
6. Therapeutic Potential of an Anti-Plac1 Antibody Drug Conjugate in a Murine Model of Human Breast Cancer, Iranian Journal of Immunology (2025)
7. Optimized Protocol for Soluble Prokaryotic Expression, Purification and Structural Analysis of Human Placenta Specific-1(Plac1), Protein Expression and Purification (2017)
8. Identification of Placenta-Specific Protein 1 (Plac-1) Expression on Human Pc-3 Cell Line-Derived Prostate Cancer Stem Cells Compared to the Tumor Parental Cells, Discover Oncology (2024)
9. Discovery of a Potential Biomarker for Immunotherapy of Melanoma: Plac1 As an Emerging Target, Immunopharmacology and Immunotoxicology (2020)
10. Placenta-Specific1 (Plac1) Is a Potential Target for Antibody-Drug Conjugate-Based Prostate Cancer Immunotherapy, Scientific Reports (2017)
11. Generation and Characterization of Novel Diagnostic Mouse Monoclonal Antibodies Against Human Estrogen Receptor Alpha and Progesterone Receptor, Asian Pacific Journal of Cancer Prevention (2022)
12. Generation and Characterization of Siglec-F-Specific Monoclonal Antibodies, Iranian Journal of Allergy# Asthma and Immunology (2017)
13. Novel Neutralizing Mouse-Human Chimeric Monoclonal Antibodies Against the Sars-Cov-2 Receptor Binding Domain, Journal of medical microbiology (2023)
14. Immunization With Placenta-Specific 1 (Plac1) Induces Potent Anti-Tumor Responses and Prolongs Survival in a Mouse Model of Melanoma, Advances in Medical Sciences (2022)
All Documents
1. Clinicopathological Significance of Plac1 Expression in Patients With Bladder Urothelial Carcinoma, International Journal of Molecular and Cellular Medicine (2026)
2. Distinct Decidualization and Senomorphic Responses in Endometrial Vs. Menstrual Blood Stem/Stromal Cells: Implications for Reproductive Therapies, Stem Cell Research and Therapy (2026)
3. Dual Regulation of Natural Killer Cells by the Decidualization Milieu: Stromal Cell-Independent and Stromal Cell-Dependent Mechanisms, Reproduction (2026)
4. Step-By-Step Preparation of Immobilized Recombinant Staphylococcus Aureus Protein a (Spa): A Versatile Tool for Efficient Antibody Purification, Avicenna Journal of Medical Biotechnology (2026)
5. The Value of Anti-Drug Antibody Detection in Discriminating Patients From Healthy Controls and Predicting the Gross Motor Functional State in Patients With Pompe Disease, Iranian Journal of Allergy, Asthma and Immunology (2026)
6. Correction To: Placenta-Specific1 (Plac1) Is a Potential Target for Antibody-Drug Conjugate-Based Prostate Cancer Immunotherapy (Scientific Reports, (2017), 7, 1, (13373), 10.1038/S41598-017-13682-9), Scientific Reports (2025)
7. Development and Evaluation of a Novel E7 Multi-Epitopic Vaccine for Human Papillomavirus Type 16: Design, Expression, Purification, and Immunological Characterization, BMC Infectious Diseases (2025)
8. Development of Novel Neutralizing Single-Chain Fragment Variable Antibodies Against S100a8, Scientific Reports (2025)
9. Editorial: Immunology at the Feto-Maternal Interface, Frontiers in Immunology (2025)
10. Increased Circulating T Helper 17 (Th17) Cells and Endometrial Tissue Il-17-Producing Cells in Patients With Endometriosis Compared With Non-Endometriotic Subjects, Reproductive Biology (2025)
11. Production and Characterization of a Panel of Anti-Mouse Placenta-Specific Protein 1 (Plac1) Monoclonal Antibodies, Analytical Biochemistry (2025)
12. Therapeutic Potential of an Anti-Plac1 Antibody Drug Conjugate in a Murine Model of Human Breast Cancer, Iranian Journal of Immunology (2025)
13. Clinico-Pathological and Prognostic Significance of a Combination of Tumor Biomarkers in Iranian Patients With Breast Cancer, Clinical Breast Cancer (2024)
14. Comparative Immunogenicity and Neutralization Potency of Four Approved Covid-19 Vaccines in Balb/C Mice, Iranian Journal of Immunology (2024)
15. Identification of Placenta-Specific Protein 1 (Plac-1) Expression on Human Pc-3 Cell Line-Derived Prostate Cancer Stem Cells Compared to the Tumor Parental Cells, Discover Oncology (2024)
16. Placenta: An Old Organ With New Functions, Frontiers in Immunology (2024)
17. Preclinical Assessment of a Recombinant Rbd-Fc Fusion Protein As Sars-Cov-2 Candidate Vaccine, European Journal of Microbiology and Immunology (2024)
18. Two Paths to Discovery: Bridging Outside-In High Throughput Technologies and Inside-Out Artificial Intelligence for Biological Decoding of Women Reproductive Failure, Journal of Reproduction and Infertility (2024)
19. Cancer Is Associated With the Emergence of Placenta-Reactive Autoantibodies, Biomedicines (2023)
20. Development and Characterization of Phage Display-Derived Anti-Toxin Antibodies Neutralizing Tcda and Tcdb of Clostridioides Difficile, Microbiology Spectrum (2023)
21. Diagnostic Performance of a Novel Antigen-Capture Elisa for the Detection of Sars-Cov-2, Analytical Biochemistry (2023)
22. Discovery of a Novel Marker for Human Granulocytes and Tissue Macrophages: Rtl1 Revisited, Cell and Tissue Research (2023)
23. Histological Evaluation of Products of Conception, Who Benefits From It?, Fetal and Pediatric Pathology (2023)
24. Investigation of Expression Profile of Placenta-Specific 1 (Plac1) in Acute Myeloid and Lymphoid Leukemias, Avicenna Journal of Medical Biotechnology (2023)
25. Novel Monoclonal Antibodies Specific for Human Ki67 and P53 Tumor Markers in Breast Cancer Tissue Samples, Iranian Journal of Immunology (2023)
26. Novel Neutralizing Mouse-Human Chimeric Monoclonal Antibodies Against the Sars-Cov-2 Receptor Binding Domain, Journal of medical microbiology (2023)
27. 2, 3, 7, 8-Tetrachlorodibenzo-P-Dioxin Potential Impacts on Peripheral Blood Mononuclear Cells of Endometriosis Women, Journal of Reproductive Immunology (2022)
28. Epitope Mapping of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Receptor Binding Domain-Specific Monoclonal Antibodies, Frontiers in Medicine (2022)
29. Generation and Characterization of Novel Diagnostic Mouse Monoclonal Antibodies Against Human Estrogen Receptor Alpha and Progesterone Receptor, Asian Pacific Journal of Cancer Prevention (2022)
30. Human Amniotic Epithelial Cells Exert Anti-Cancer Effects Through Secretion of Immunomodulatory Small Extracellular Vesicles (Sev), Cancer Cell International (2022)
31. Identification of Immunodominant Epitopes on Nucleocapsid and Spike Proteins of the Sars-Cov-2 in Iranian Covid-19 Patients, Pathogens and Disease (2022)
32. Immunization With Placenta-Specific 1 (Plac1) Induces Potent Anti-Tumor Responses and Prolongs Survival in a Mouse Model of Melanoma, Advances in Medical Sciences (2022)
33. Introduction of an Efficient Method for Placenta Decellularization With High Potential to Preserve Ultrastructure and Support Cell Attachment, Artificial Organs (2022)
34. Adoptive Cell Therapy With Induced Regulatory T Cells Normalises the Abortion Rate in Abortion-Prone Mice, Reproduction# Fertility and Development (2021)
35. Culture Density of Menstrual Blood-Derived Stromal/Stem Cells Determines the Quality of T Cell Responses: An Experimental Study, International Journal of Reproductive BioMedicine (2021)
36. Differential Antibody Response to Sars-Cov-2 Antigens in Recovered and Deceased Iranian Covid-19 Patients, Viral Immunology (2021)
37. Does Prior Immunization With Measles, Mumps, and Rubella Vaccines Affect the Antibody Response to Covid-19 Antigens?, Iranian Journal of Immunology (2021)
38. Endometrial Mesenchymal Stem/Stromal Cells: The Enigma to Code Messages for Generation of Functionally Active Regulatory T Cells, Stem Cell Research and Therapy (2021)
39. Expression Profiling of Rtl1 in Human Breast Cancer Tissues and Cell Lines, Experimental and Molecular Pathology (2021)
40. Hpv16-E7 Protein T Cell Epitope Prediction and Global Therapeutic Peptide Vaccine Design Based on Human Leukocyte Antigen Frequency: An In-Silico Study, International Journal of Peptide Research and Therapeutics (2021)
41. Menscs Exert a Supportive Role in Establishing a Pregnancy-Friendly Microenvironment by Inhibiting Th17 Polarization, Journal of Reproductive Immunology (2021)
42. Mesenchymal Stem Cells Induce Expansion of Regulatory T Cells in Abortion-Prone Mice, Reproduction (2021)
43. Methylation of Tgm-3 Promoter and Its Association With Oral Squamous Cell Carcinoma (Oscc), Avicenna Journal of Medical Biotechnology (2021)
44. Novel Method for the Isolation of Proteins and Small Target Molecules From Biological and Aqueous Media by Salt-Assisted Phase Transformation of Their Pegylated Recognition Counterparts, ACS Omega (2021)
45. Optimization of Expression and Purification of Recombinant Mouse Plac1, Avicenna Journal of Medical Biotechnology (2021)
46. Proteome Profiling of Human Placenta Reveals Developmental Stage-Dependent Alterations in Protein Signature, Clinical Proteomics (2021)
47. Pyrvinium Pamoate Induces In-Vitro Suppression of Il-6 and Il-8 Produced by Human Endometriotic Stromal Cells, Human and Experimental Toxicology (2021)
48. Thyroid Peroxidase in Human Endometrium and Placenta: A Potential Target for Anti-Tpo Antibodies, Clinical and Experimental Medicine (2021)
49. Thyroid Peroxidase in Human Endometrium and Placenta: A Potential Target for Anti-Tpo Antibodies, Clinical and Experimental Medicine (2021)
50. Vitamin D3 Controls Tlr4- and Tlr2-Mediated Inflammatory Responses of Endometrial Cells, Gynecologic and Obstetric Investigation (2021)
51. Assessing the Potential of Hspa2 and Adam2 As Two Biomarkers for Human Sperm Selection, Human Fertility (2020)
52. Discovery of a Potential Biomarker for Immunotherapy of Melanoma: Plac1 As an Emerging Target, Immunopharmacology and Immunotoxicology (2020)
53. Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application, Frontiers in Cell and Developmental Biology (2020)
54. Evaluation of Apoptosis and Angiogenesis in Ectopic and Eutopic Stromal Cells of Patients With Endometriosis Compared to Non-Endometriotic Controls, BMC Women's Health (2020)
55. Expression of Human Placenta-Specific 1 (Plac1) in Cho-K1 Cells, Avicenna Journal of Medical Biotechnology (2020)
56. Functional Study of a Camelid Single Domain Anti-Cd22 Antibody, International Journal of Peptide Research and Therapeutics (2020)
57. Higher Frequency of Circulating, But Not Tissue Regulatory T Cells in Patients With Endometriosis, Journal of Reproductive Immunology (2020)
58. Monoclonal Antibodies for Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
59. Overexpression and Translocation of Dynamin 2 Promotes Tumor Aggressiveness in Breast Carcinomas, EXCLI Journal (2020)
60. Surface Modification and Bioconjugation of Anti-Cd4 Monoclonal Antibody to Magnetic Nanoparticles As a Highly Efficient Affinity Adsorbent for Positive Selection of Peripheral Blood T Cd4+ Lymphocytes, International Journal of Biological Macromolecules (2020)
61. A Truncated Snail1 Transcription Factor Alters the Expression of Essential Emt Markers and Suppresses Tumor Cell Migration in a Human Lung Cancer Cell Line, Recent Patents on Anti-Cancer Drug Discovery (2019)
62. Antibody-Drug Conjugates: Possibilities and Challenges, Avicenna Journal of Medical Biotechnology (2019)
63. Diminished Frequency of Menstrual and Peripheral Blood Nkt-Like Cells in Patients With Unexplained Recurrent Spontaneous Abortion and Infertile Women, Reproductive Sciences (2019)
64. Expression Profiling of Plac1 in Murine Cancer Cell Lines, Experimental Oncology (2019)
65. High Dose Pomegranate Extract Suppresses Neutrophil Myeloperoxidase and Induces Oxidative Stress in a Rat Model of Sepsis, International Journal for Vitamin and Nutrition Research (2019)
66. Human Menstrual Blood-Derived Stromal/Stem Cells Modulate Functional Features of Natural Killer Cells, Scientific Reports (2019)
67. Intra-Arterial Drug Delivery to the Ischemic Brain in Rat Middle Cerebral Artery Occlusion Model, Bio-protocol (2019)
68. Melatonin Regulates Neuroinflammation Ischemic Stroke Damage Through Interactions With Microglia in Reperfusion Phase, Brain Research (2019)
69. Plac1: Biology and Potential Application in Cancer Immunotherapy, Cancer Immunology# Immunotherapy (2019)
70. Bilayer Amniotic Membrane/Nano-Fibrous Fibroin Scaffold Promotes Differentiation Capability of Menstrual Blood Stem Cells Into Keratinocyte-Like Cells, Molecular Biotechnology (2018)
71. Bioimaging Based on Antibody-Conjugated Amphiphilic Polymer-Core@Shell Quantum Dots, Emerging Materials Research (2018)
72. Comparative Effectiveness of Three-Dimensional Scaffold, Differentiation Media and Co-Culture With Native Cardiomyocytes to Trigger in Vitro Cardiogenic Differentiation of Menstrual Blood and Bone Marrow Stem Cells, Biologicals (2018)
73. Differential Serostatus of Epstein-Barr Virus in Iranian Ms Patients With Various Clinical Patterns, Medical Journal of the Islamic Republic of Iran (2018)
74. Evaluation of Immunophenotyping, Proliferation and Osteogenic Differentiation Potential of Ssea-4 Positive Stem Cells Derived From Pulp of Deciduous Teeth, Archives of Oral Biology (2018)
75. Human Amniotic Epithelial Cells Inhibit Activation and Pro-Inflammatory Cytokines Production of Naive Cd4+ T Cells From Women With Unexplained Recurrent Spontaneous Abortion, Reproductive Biology (2018)
76. Human Amniotic Epithelial Cells Inhibit Activation and Pro-Inflammatory Cytokines Production of Naive Cd4+ T Cells From Women With Unexplained Recurrent Spontaneous Abortion, Reproductive Biology (2018)
77. Immunomodulatory Effects of Human Amniotic Epithelial Cells on Naive Cd4+ T Cells From Women With Unexplained Recurrent Spontaneous Abortion, Placenta (2018)
78. Immunomodulatory Effects of Human Amniotic Epithelial Cells on Naive Cd4+ T Cells From Women With Unexplained Recurrent Spontaneous Abortion, Placenta (2018)
79. Menstrual Blood-Derived Stromal Stem Cells Augment Cd4+ T Cells Proliferation, Avicenna Journal of Medical Biotechnology (2018)
80. Mouse Preantral Follicle Growth in 3D Co-Culture System Using Human Menstrual Blood Mesenchymal Stem Cell, Reproductive Biology (2018)
81. Promotion of Excisional Wound Repair by a Menstrual Blood-Derived Stem Cell-Seeded Decellularized Human Amniotic Membrane, Biomedical Engineering Letters (2018)
82. Quantum Dot-Labeled Tags Improve Minimal Detection Limit of Ca125 in Ovarian Cancer Cells and Tissues, Iranian Journal of Allergy# Asthma and Immunology (2018)
83. Vaccination With Human Amniotic Epithelial Cells Confer Effective Protection in a Murine Model of Colon Adenocarcinoma, International Journal of Cancer (2018)
84. Brucella Melitensis Virb12 Recombinant Protein Is a Potential Marker for Serodiagnosis of Human Brucellosis, Annals of Clinical Microbiology and Antimicrobials (2017)
85. Cell Separation: Potentials and Pitfalls, Preparative Biochemistry and Biotechnology (2017)
86. Comparative Capability of Menstrual Blood Versus Bone Marrow Derived Stem Cells in Neural Differentiation, Molecular Biology Reports (2017)
87. Differentiation of Bone Marrow-Derived Stage-Specific Embryonic Antigen 1 Positive Pluripotent Stem Cells Into Male Germ Cells, Microscopy Research and Technique (2017)
88. Generation and Characterization of Siglec-F-Specific Monoclonal Antibodies, Iranian Journal of Allergy# Asthma and Immunology (2017)
89. In Vitro Differentiation of Menstrual Blood Stem Cells Into Keratinocytes: A Potential Approach for Management of Wound Healing, Biologicals (2017)
90. Mesenchymal Stem Cells Increase Skin Graft Survival Time and Up-Regulate Pd-L1 Expression in Splenocytes of Mice, Immunology Letters (2017)
91. Nickel-Salen Supported Paramagnetic Nanoparticles for 6-His-Target Recombinant Protein Affinity Purification, Journal of Chromatography A (2017)
92. Optimized Protocol for Soluble Prokaryotic Expression, Purification and Structural Analysis of Human Placenta Specific-1(Plac1), Protein Expression and Purification (2017)
93. Placenta-Specific1 (Plac1) Is a Potential Target for Antibody-Drug Conjugate-Based Prostate Cancer Immunotherapy, Scientific Reports (2017)
94. Sciatic Nerve Regeneration by Transplantation of Menstrual Blood-Derived Stem Cells, Molecular Biology Reports (2017)
95. A Shift in the Balance of T17 and Treg Cells in Menstrual Blood of Women With Unexplained Recurrent Spontaneous Abortion, Journal of Reproductive Immunology (2016)
96. Comparative Immunophenotypic Characteristics, Proliferative Features, and Osteogenic Differentiation of Stem Cells Isolated From Human Permanent and Deciduous Teeth With Bone Marrow, Molecular Biotechnology (2016)
97. Fast and Highly Efficient Purification of 6×Histidine-Tagged Recombinant Proteins by Ni-Decorated Mnfe2o4@Sio2@Nh2@2Ab As Novel and Efficient Affinity Adsorbent Magnetic Nanoparticles, RSC Advances (2016)
98. Placental Kisspeptins Differentially Modulate Vital Parameters of Estrogen Receptor-Positive And-Negative Breast Cancer Cells, PLoS ONE (2016)
99. Synthesis of Depo-Medrol–Chitosan Hydrogel As New Drug Slow-Release Appliance and Investigation of Release Kinetics by High-Performance Liquid Chromatography, Biomedical Chromatography (2016)
100. The Use of Objective Oriented Project Planning Tools for Nanosafety and Health Concerns: A Case Study in Nanomedicine Research Project, European Journal of Nanomedicine (2016)
101. Vitamin a Decreases Cytotoxicity of Oxidized Low-Density Lipoprotein in Patients With Atherosclerosis, Immunological Investigations (2016)
102. Comparable Vitamin D3 Metabolism in the Endometrium of Patients With Recurrent Spontaneous Abortion and Fertile Controls, Molecular Reproduction and Development (2015)
103. Efficient Generation of Functional Hepatocyte-Like Cells From Menstrual Blood-Derived Stem Cells, Journal of Tissue Engineering and Regenerative Medicine (2015)
104. Lipopolysaccharide- and Lipoteichoic Acid-Mediated Pro-Inflammatory Cytokine Production and Modulation of Tlr2, Tlr4 and Myd88 Expression in Human Endometrial Cells, Journal of Reproduction and Infertility (2015)
105. Menstrual Blood Contains Immune Cells With Inflammatory and Anti-Inflammatory Properties, Journal of Obstetrics and Gynaecology Research (2015)
106. Molecular Characterization of Murine Monoclonal Antibody Variable Regions Specific for Hepatitis B Surface Antigen, Viral Immunology (2015)
107. Simultaneous Immunization of Mice With Omp31 and Tf Provides Protection Against Brucella Melitensis Infection, Vaccine (2015)