Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Site Directed Disulfide Pegylation of Interferon-Β-1B With Fork Peptide Linker
Mohammad Reza Fazeli
Mohammad Reza Fazeli

Professor of Microbiology

Department Food and Drug Control

School of Pharmacy

Pharmaceutical Quality Assurance Research Center

Tehran University of Medical Sciences

All Documents
1. Management of Cardiovascular Diseases by Short-Chain Fatty Acid Postbiotics, Current Nutrition Reports (2024)
2. Biosynthesis of Zinc Oxide Nanoparticles Using Fermented Table Olive Extract: A Novel and Green Approach With Potential Applications, BioNanoScience (2023)
3. Developing a New Biologic Toxin Binder for Reducing Afb1 Toxicity in Laying Hens, Letters in Applied Microbiology (2023)
4. Hierarchically-Structured Laccase@Ni3(Po4)2 Hybrid Nanoflowers for Antibiotic Degradation: Application in Real Wastewater Effluent and Toxicity Evaluation, International Journal of Biological Macromolecules (2023)
5. Lactobacillus Crispatus and Human Herpes Simplex Virus-2, an in Vitro Study, Molecular Genetics# Microbiology and Virology (2023)
6. Pilot-Plant Scale Biomass Production by Lactobacillus Rhamnosus Gg Atcc 53103: A Comparison Between Batch and Fed-Batch Fermentation, Journal of Microbiology# Biotechnology and Food Sciences (2023)
7. The Synergistic Effect of Titanium Dioxide Nanoparticles and Yeast Isolated From Fermented Foods in Reduction of Aflatoxin B1, Food Science and Nutrition (2023)
8. A New Probiotic Lactobacillus Plantarum Strain Isolated From Traditional Dairy Together With Nanochitosan Particles Shows the Synergistic Effect on Aflatoxin B1 Detoxification, Archives of Microbiology (2022)
9. A Simplified Process for Purification and Refolding of Recombinant Human Interferon-Α2b, Iranian Biomedical Journal (2022)
10. Formulation, Characterization, and Bioactivity Assessments of a Laccase-Based Mouthwash, Journal of Drug Delivery Science and Technology (2022)
11. Growth Promoting Activity, Anti-Biofilm Effect, and Down Regulation of Papc and Rcsa Genes Expression by Medicago Sativa (Alfalfa) Extract, Food Bioscience (2022)
12. Isolation and Biochemical and Molecular Identification of Lactobacilli From Traditional Dairy in Fars Province and Investigation of Their Probiotic Potential, Journal of Food Science and Technology (Iran) (2022)
13. Isolation, Screening and Identification of Native and New Bacillus Subtilis With Strong Antifungal Compound Against Fusarium Oxysporum, Biocontrol Science (2022)
14. Nanobiosensor Based on Sugar Code-Aunps Aggregation: A Key to Opening New Gates in Rapid Diagnosis of Streptococcal Pharyngitis, Frontiers in Bioengineering and Biotechnology (2022)
15. Synergistic Effects of Probiotic Bifidobacterium Isolated From Chicken's Intestine in Combination With Polyvinylpyrrolidone on Reduction of Aflatoxin B1, Letters in Applied Microbiology (2022)
16. Bacteriocin Activity of Various Iranian Honey‐Associated Bacteria and Development of a Simple Medium for Enhanced Bacteriocin Activity, Journal of Environmental Health Science and Engineering (2021)
17. Comparative Effect of Probiotic and Paraprobiotic Addition on Physicochemical, Chemometric and Microstructural Properties of Yogurt, LWT (2021)
18. Comparative Effect of Probiotic and Paraprobiotic Addition on Rheological and Sensory Properties of Yoghurt, International Journal of Dairy Technology (2021)
19. Comparative Effects of Probiotic and Paraprobiotic Addition on Microbiological, Biochemical and Physical Properties of Yogurt, Food Research International (2021)
20. Development of an Enzyme-Enhancer System to Improve Laccase Biological Activities, International Journal of Biological Macromolecules (2021)
21. Efficacy of Probiotics for Managing Infantile Colic Due to Their Anti-Inflammatory Properties: A Meta-Analysis and Systematic Review, Clinical and Experimental Pediatrics (2021)
22. Combination of Thermal and Biological Treatments for Bio-Removal and Detoxification of Some Recalcitrant Synthetic Dyes by Betaine-Induced Thermostabilized Laccase, Environmental Technology and Innovation (2020)
23. Effects of Synbiotic Supplementation on Gut Microbiome, Serum Level of Tnf-Α, and Expression of Microrna-126 and Microrna-146A in Patients With Type 2 Diabetes Mellitus: Study Protocol for a Double-Blind Controlled Randomized Clinical Trial, Trials (2020)
24. Interferon Β-1B in Treatment of Severe Covid-19: A Randomized Clinical Trial, International Immunopharmacology (2020)
25. Solubilization of Human Interferon Β-1B Inclusion Body Proteins by Organic Solvents, Advanced Pharmaceutical Bulletin (2020)
26. Down-Regulatory Effects of Green Coffee Extract on Las I and Las R Virulence-Associated Genes in Pseudomonas Aeruginosa, DARU# Journal of Pharmaceutical Sciences (2019)
27. Production of Vitamin D3 Enriched Biomass of Saccharomyces Cerevisiae As a Potential Food Supplement: Evaluation and Optimization of Culture Conditions Using Plackett–Burman and Response Surface Methodological Approaches, Iranian Journal of Pharmaceutical Research (2019)
28. A Survey of Antibacterial Effects of Oliveria Decumbens and Nepeta Binaludensis Essential Oils on Staphylococcus Aureus and Escherichia Coli in Doogh, Journal of Medicinal Plants (2018)
29. Determination of Biological Activity of Recombinant Reteplase Using Clot Lysis Time and Activated Partial Thromboplastin Time (Aptt) Lysis Methods: A Comparative Study, Iranian Journal of Pharmaceutical Research (2018)
30. Development of a Two-Step Refolding Method for Reteplase, a Rich Disulfide-Bonded Protein, Process Biochemistry (2018)
31. Efficiency of Multispecies Probiotic Supplements in Bioremoval of Bisphenol A: An in Vitro Study, Applied Food Biotechnology (2018)
32. Growth Inhibitory Effect of Lactocare on Vibrio Cholerae, Iranian Journal of Pathology (2018)
33. Effect of Nonionic Surfactants (Dodecyl Maltoside and Polysorbate 20) on Prevention of Aggregation and Conformational Changes of Recombinant Human Ifnβ_1B Induced by Light, Iranian Journal of Pharmaceutical Research (2017)
34. Effects of a Multispecies Probiotic Supplement on Bone Health in Osteopenic Postmenopausal Women: A Randomized, Double-Blind, Controlled Trial, Journal of the American College of Nutrition (2017)
35. Optimization of Culture Conditions for Enrichment of Saccharomyces Cerevisiae With Dl-Α-Tocopherol by Response Surface Methodology, Iranian Journal of Pharmaceutical Research (2017)
36. Purification and Efficient Refolding Process for Recombinant Tissue-Type Plasminogen Activator Derivative (Reteplase) Using Glycerol and Tranexamic Acid, Process Biochemistry (2017)
37. An Albumin-Free Formulation for Escherichia Coli-Derived Interferon Beta-1B With Decreased Immunogenicity in Immune Tolerant Mice, Journal of Interferon and Cytokine Research (2016)
38. Immunogenicity of Recombinant Human Interferon Beta-1B in Immune-Tolerant Transgenic Mice Corresponds With the Biophysical Characteristics of Aggregates, Journal of Interferon and Cytokine Research (2016)
39. A Novel Clot Lysis Assay for Recombinant Plasminogen Activator, Biotechnology Letters (2015)
40. Development and Validation of a Micellar Capillary Electrophoresis Method for Determination of Ifnβ-1B in Lyophilized Formulation of a Biosimilar Product, Iranian Journal of Pharmaceutical Research (2015)
41. Factors Affecting Viability of Bifidobacterium Bifidum During Spray Drying, DARU# Journal of Pharmaceutical Sciences (2015)
42. Isolation and Structural Characterization of Coryxin, a Novel Cyclic Lipopeptide From Corynebacterium Xerosis Ns5 Having Emulsifying and Anti-Biofilm Activity, Colloids and Surfaces B: Biointerfaces (2015)
43. Isolation of Lactobacillus Acidophilus and Assessment for Its Antiviral Effect Against Herpes Simplex Virus Type Ii, Molecular Genetics# Microbiology and Virology (2015)
44. Preventing Aggregation of Recombinant Interferon Beta-1B in Solution by Additives: Approach to an Albumin-Free Formulation, Advanced Pharmaceutical Bulletin (2015)
45. Effects of Supplementation With Probiotics on Long-Term Potentiation Impairment in Diabetic Rats, Journal of Isfahan Medical School (2013)
46. Optimization of Enzymatic Synthesis of Ampicillin Using Cross-Linked Aggregates of Penicillin G Acylase, Iranian Journal of Pharmaceutical Research (2004)