Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Dihydropyrimidine Derivatives As Mdm2 Inhibitors
Mahboubeh Rostami
Mahboubeh Rostami

Assistant Professor of Organic Chemistry

Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences

Novel Drug Delivery Systems Research Center

Isfahan University of Medical Sciences

Related Documents
1. Dihydropyrimidine Derivatives As Mdm2 Inhibitors, Chemical Biology and Drug Design (2024)
2. Pyrimido[4,5-B]Indole Derivatives Bearing 1,2,4-Oxadiazole Moiety As Mdm2 Inhibitor Candidates in Cancer Treatment, Future Medicinal Chemistry (2023)
3. Monastrol Derivatives: In Silico and in Vitro Cytotoxicity Assessments, Research in Pharmaceutical Sciences (2020)
4. Design, Synthesis, and Cytotoxicity Evaluation of Novel Indole-Acylhydrazone Derivatives of 4-Pyridinone As Potential Histone Deacetylase-2 Inhibitors, Research in Pharmaceutical Sciences (2022)
5. The Art of Design in Azlactone-Benzoxazinone Chemistry, Docking Studies and in Vitro Cytotoxicity Evaluation, Australian Journal of Chemistry (2022)
6. Hybrid Derivatives Containing Dimethyl Fumarate and Benzothiazole Scaffolds for the Potential Treatment of Multiple Sclerosis; in Silico & in Vivo Study, DARU, Journal of Pharmaceutical Sciences (2024)
7. Synthesis, Characterization, Cytotoxic Screening, and Density Functional Theory Studies of New Derivatives of Quinazolin-4(3H)-One Schiff Bases, Research in Pharmaceutical Sciences (2017)
8. Novel Tocopherol Succinate-Polyoxomolybdate Bioconjugate As Potential Anti-Cancer Agent, Journal of Inorganic and Organometallic Polymers and Materials (2021)
9. Some Novel Hybrid Quinazoline-Based Heterocycles As Potent Cytotoxic Agents, Research in Pharmaceutical Sciences (2022)
10. Biological Evaluation, Docking and Molecular Dynamic Simulation of Some Novel Diaryl Urea Derivatives Bearing Quinoxalindione Moiety, Research in Pharmaceutical Sciences (2017)
11. Synthesis, Characterization, Molecular Docking, Antimalarial, and Antiproliferative Activities of Benzyloxy-4-Oxopyridin Benzoate Derivatives, Research in Pharmaceutical Sciences (2022)
All Documents
1. Comparing the Transfection Efficiency of Cationic Monomer Ratios in Vinylimidazole and Aminoethyl Methacrylate Copolymers, International Journal of Pharmaceutics: X (2025)
2. A Forsterite-Reinforced Polypropylene Fumarate/Methoxy Polyethylene Glycol-Hydrogel Enriched With Flavonoid Nanoparticles Enhances Osteoconductivity, Materials Advances (2024)
3. Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells, Journal of Inorganic and Organometallic Polymers and Materials (2024)
4. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
5. Co-Delivery of Dasatinib and Mir-30A by Liposomes Targeting Neuropilin-1 Receptors for Triple-Negative Breast Cancer Therapy, Journal of Materials Chemistry B (2024)
6. Dihydropyrimidine Derivatives As Mdm2 Inhibitors, Chemical Biology and Drug Design (2024)
7. Hybrid Derivatives Containing Dimethyl Fumarate and Benzothiazole Scaffolds for the Potential Treatment of Multiple Sclerosis; in Silico & in Vivo Study, DARU, Journal of Pharmaceutical Sciences (2024)
8. Polyoxometalates As Next-Generation of Theragnostic Gadgets in Cancer, Reviews in Inorganic Chemistry (2024)
9. Anderson-Type Manganese Polyoxomolybdate Hybrid Nanocomposite for Boosting Drug Delivery Against Breast Cancer, Journal of Drug Delivery Science and Technology (2023)
10. Anderson-Type Manganese Polyoxomolybdate Hybrid Nanocomposite for Boosting Drug Delivery Against Breast Cancer, Journal of Drug Delivery Science and Technology (2023)
11. Anti Her-2 Aptamer Functionalized Gold Nanoparticles of Dasatinib for Targeted Chemo-Radiotherapy in Breast Cancer Cells, Biomaterials Advances (2023)
12. Arsenic Polyoxotungstate-Zeolitic Imidazolate Framework-8 As a Potential Selective Anti-Cancer Nano Platform, Journal of Inorganic and Organometallic Polymers and Materials (2023)
13. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
14. Novel Mr Imaging Nanoprobe for Hepatocellular Carcinoma Detection Based on Manganese–Zinc Ferrite Nanoparticles: In Vitro and in Vivo Assessments, Journal of Cancer Research and Clinical Oncology (2023)
15. Peptide-Based Pegylated Polyurethane Nanoparticles for Paclitaxel Delivery in Hela Cancer Cells: The Art of the Architecture Design in Nanocarriers, Polymer Bulletin (2023)
16. Pyrimido[4,5-B]Indole Derivatives Bearing 1,2,4-Oxadiazole Moiety As Mdm2 Inhibitor Candidates in Cancer Treatment, Future Medicinal Chemistry (2023)
17. Thermosensitive Tmpo-Oxidized Lignocellulose/Cationic Agarose Hydrogel Loaded With Deferasirox Nanoparticles for Photothermal Therapy in Melanoma, International Journal of Biological Macromolecules (2023)
18. Copper-Curcumin-Bipyridine Dicarboxylate Complexes As Anticancer Candidates, Chemistry and Biodiversity (2022)
19. Design, Synthesis, and Cytotoxicity Evaluation of Novel Indole-Acylhydrazone Derivatives of 4-Pyridinone As Potential Histone Deacetylase-2 Inhibitors, Research in Pharmaceutical Sciences (2022)
20. Development and Validation of a New Robust Rp-Hplc Method for Simultaneous Quantitation of Insulin and Pramlintide in Non-Invasive and Smart Glucose-Responsive Microparticles, Research in Pharmaceutical Sciences (2022)
21. Hyaluronic Acid Targeted Metal Organic Framework Based on Iron (Iii) for Delivery of Platinum Curcumin Cytotoxic Agent to Triple Negative Breast Cancer Cell Line, Applied Organometallic Chemistry (2022)
22. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
23. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
24. Redox Responsive Polymeric Micelles of Gellan Gum/Abietic Acid for Targeted Delivery of Ribociclib, International Journal of Biological Macromolecules (2022)
25. Some Novel Hybrid Quinazoline-Based Heterocycles As Potent Cytotoxic Agents, Research in Pharmaceutical Sciences (2022)
26. Synthesis, Characterization, Molecular Docking, Antimalarial, and Antiproliferative Activities of Benzyloxy-4-Oxopyridin Benzoate Derivatives, Research in Pharmaceutical Sciences (2022)
27. The Art of Design in Azlactone-Benzoxazinone Chemistry, Docking Studies and in Vitro Cytotoxicity Evaluation, Australian Journal of Chemistry (2022)
28. Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and in Vitro Cytotoxicity Evaluations, Langmuir (2021)
29. Boron Phenyl Alanine Targeted Chitosan–Pnipaam Core–Shell Thermo-Responsive Nanoparticles: Boosting Drug Delivery to Glioblastoma in Bnct, Drug Development and Industrial Pharmacy (2021)
30. Boron Phenyl Alanine Targeted Ionic Liquid Decorated Chitosan Nanoparticles for Mitoxantrone Delivery to Glioma Cell Line, Pharmaceutical Development and Technology (2021)
31. Design, Synthesis, and Bio-Evaluation of New Isoindoline-1,3-Dione Derivatives As Possible Inhibitors of Acetylcholinesterase, Research in Pharmaceutical Sciences (2021)
32. Design, Synthesis, Biological Evaluation, and Molecular Docking Study on Triazine Based Derivatives As Anti-Inflammatory Agents, Journal of Molecular Structure (2021)
33. Eudesmic Acid-Polyoxomolybdate Organo-Conjugate As Novel Anticancer Agent, Journal of Molecular Structure (2021)
34. Novel Tocopherol Succinate-Polyoxomolybdate Bioconjugate As Potential Anti-Cancer Agent, Journal of Inorganic and Organometallic Polymers and Materials (2021)
35. Synthesis and Antiplatelet Activity Evaluation of a Group of Novel Ethyl Acetoacetate Phenylhydrazone Derivatives, Iranian Journal of Pharmaceutical Research (2021)
36. Anti-Cancer Activity of Biotin-Polyoxomolybdate Bioconjugate, Eurasian Journal of Medicine and Oncology (2020)
37. Enhanced Antitumor Activity of Bovine Lactoferrin Through Immobilization Onto Functionalized Nano Graphene Oxide: An In Vitro/In Vivo Study, Drug Delivery (2020)
38. Monastrol Derivatives: In Silico and in Vitro Cytotoxicity Assessments, Research in Pharmaceutical Sciences (2020)
39. Photosensitization of Phthalocyanine for Singlet Oxygen Generation in Photodynamic Therapy Applications, Journal of Medicinal and Chemical Sciences (2020)
40. Preparation and Evaluation of Inhalable Dry Powder Containing Glucosamine-Conjugated Gefitinib Slns for Lung Cancer Therapy, Drug Development and Industrial Pharmacy (2020)
41. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
42. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
43. Assessment of Manganese-Zinc Ferrite Nanoparticles As a Novel Magnetic Resonance Imaging Contrast Agent for the Detection of 4T1 Breast Cancer Cells, Journal of Medical Signals and Sensors (2019)
44. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
45. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
46. Pegylated Trimethylchitosan Emulsomes Conjugated to Octreotide for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma Cells of Hepg2, Journal of Liposome Research (2019)
47. Synthesis of Pectin-Deoxycholic Acid Conjugate for Targeted Delivery of Anticancer Drugs in Hepatocellular Carcinoma, International Journal of Biological Macromolecules (2019)
48. A Mucoadhesive Thermosensitive Hydrogel Containing Erythropoietin As a Potential Treatment in Oral Mucositis: In Vitro and in Vivo Studies, Drug Delivery and Translational Research (2018)
49. A Novel Mixed Polymeric Micelle for Co-Delivery of Paclitaxel and Retinoic Acid and Overcoming Multidrug Resistance: Synthesis, Characterization, Cytotoxicity, and Pharmacokinetic Evaluation, Drug Development and Industrial Pharmacy (2018)
50. Assessment of Chitosan Modified Nanoparticles, As Boron Carriers in Bnct, Journal of Mazandaran University of Medical Sciences (2018)
51. Folic Acid Targeted Polymeric Micelles Based on Tocopherol Succinate-Pulluan As an Effective Carrier for Epirubicin: Preparation, Characterization and In-Vitro Cytotoxicity Assessment, Current Drug Delivery (2018)
52. Novel Ngr Anchored Pullulan Micelles for Controlled and Targeted Delivery of Doxorubicin to Hela Cancerous Cells, Iranian Polymer Journal (English Edition) (2018)
53. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
54. Synthesis and Characterization of Novel Biodegradable Water Dispersed Poly(Ether-Urethane)S and Their Mwcnt-As Nanocomposites Functionalized With Aspartic Acid As Dispersing Agent, Iranian Polymer Journal (English Edition) (2018)
55. Synthesis and Characterization of Some Novel Diaryl Urea Derivatives Bearing Quinoxalindione Moiety, Research in Pharmaceutical Sciences (2018)
56. Biological Evaluation, Docking and Molecular Dynamic Simulation of Some Novel Diaryl Urea Derivatives Bearing Quinoxalindione Moiety, Research in Pharmaceutical Sciences (2017)
57. Docking Study, Synthesis and Antimicrobial Evaluation of Some Novel 4-Anilinoquinazoline Derivatives, Research in Pharmaceutical Sciences (2017)
58. Poly (Ethylene-Co-Vinyl Alcohol)-Based Polymeric Thermo-Responsive Nanocarriers for Controlled Delivery of Epirubicin to Hepatocellular Carcinoma, Research in Pharmaceutical Sciences (2017)
59. Synthesis of Biotin-Targeted Chitosan/Poly (Methyl Vinyl Ether- Alt -Maleic Acid) Copolymeric Micelles for Delivery of Doxorubicin, IET Nanobiotechnology (2017)
60. Synthesis, Characterization, Cytotoxic Screening, and Density Functional Theory Studies of New Derivatives of Quinazolin-4(3H)-One Schiff Bases, Research in Pharmaceutical Sciences (2017)
61. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
62. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
63. In Vivo Pharmacokinetics, Biodistribution and Anti-Tumor Effect of Paclitaxel-Loaded Targeted Chitosan-Based Polymeric Micelle, Drug Delivery (2016)
64. Thermosensitive Folic Acid-Targeted Poly (Ethylene-Co-Vinyl Alcohol) Hemisuccinate Polymeric Nanoparticles for Delivery of Epirubicin to Breast Cancer Cells, Iranian Polymer Journal (English Edition) (2016)
65. A Rapid and Sensitive Hplc Method for Quantitation of Paclitaxel in Biological Samples Using Liquid-Liquid Extraction and Uv Detection: Application to Pharmacokinetics and Tissues Distribution Study of Paclitaxel Loaded Targeted Polymeric Micelles in Tumor Bearing Mice, Journal of Pharmacy and Pharmaceutical Sciences (2015)
66. Co-Delivery of Paclitaxel and Α-Tocopherol Succinate by Novel Chitosan-Based Polymeric Micelles for Improving Micellar Stability and Efficacious Combination Therapy, Drug Development and Industrial Pharmacy (2015)
67. Design, Synthesis and Anti-Hiv-1 Evaluation of a Series of 5-Hydroxypyridine-4-One Derivatives As Possible Integrase Inhibitors, Medicinal Chemistry Research (2015)
68. Development and in Vitro/In Vivo Evaluation of a Novel Targeted Polymeric Micelle for Delivery of Paclitaxel, International Journal of Biological Macromolecules (2015)
69. Feasibility of Haloperidol-Anchored Albumin Nanoparticles Loaded With Doxorubicin As Dry Powder Inhaler for Pulmonary Delivery, Pharmaceutical Development and Technology (2015)
70. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma, BioMed Research International (2015)
71. Methotrexate-Grafted-Oligochitosan Micelles As Drug Carriers: Synthesis and Biological Evaluations, Journal of Materials Science: Materials in Medicine (2015)
72. Self-Assembly Micelles With Lipid Core of Cholesterol for Docetaxel Delivery to B16f10 Melanoma and Hepg2 Cells, Journal of Liposome Research (2015)
73. Synthesis of Some New Porphyrins and Their Metalloderivatives As Potential Sensitizers in Photo-Dynamic Therapy, Research in Pharmaceutical Sciences (2015)
74. 2W10o32 Catalyzed Efficient One-Pot Pseudo-Four Component Synthesis of At-130 Analogues Under Microwave Irradiations, Journal of the Iranian Chemical Society (2014)
75. Novel Worm-Like Amphiphilic Micelles of Folate-Targeted Cyclodextrin/Retinoic Acid for Delivery of Doxorubicin in Kg-1 Cells, Colloid and Polymer Science (2014)
76. Synthesis and Characterization of Folate-Targeted Dextran/Retinoic Acid Micelles for Doxorubicin Delivery in Acute Leukemia, BioMed Research International (2014)
77. Synthesis of Pluronic® F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Copolymer and Production of Its Micelles for Doxorubicin Delivery in Breast Cancer, Chemical Engineering Journal (2014)
78. Retinoic Acid Decorated Albumin-Chitosan Nanoparticles for Targeted Delivery of Doxorubicin Hydrochloride in Hepatocellular Carcinoma, Journal of Nanomaterials (2013)
79. Iron Chelation Afforded Cardioprotection Against H2o 2-Induced H9c2 Cell Injury: Application of Novel 3-Hydroxy Pyridine-4-One Derivatives, International Journal of Cardiology (2012)
80. Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design, Journal of Nanomaterials (2012)
81. Synthesis and Antioxidant Evaluation of 4-(Furan-2-Yl)-6-Methyl-2- Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate Esters, Research in Pharmaceutical Sciences (2012)
82. Synthesis and Antioxidant Evaluation of Some Novel Orthohydroxypyridine- 4-One Iron Chelators, Research in Pharmaceutical Sciences (2012)