Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synergistic Effects of Carbohydrate Polymers on the Performance of Hybrid Injectable Bone Pastes Publisher



Salehi G1 ; Behnamghader A1 ; Hesaraki S1 ; Mozafari M1, 2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  2. 2. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: European Polymer Journal Published:2019


Abstract

During the past few years, invasive surgery operations using injectable systems, have been applied for the treatment of osteoporosis bone defects. In this research, different injectable pastes made from natural polymer such as gelatin (Ge), carboxymethyl cellulose (CMC), alginate (Alg) and inorganic materials containing hydroxyapatite (HA) and biphasic calcium phosphate (BCP) were studied. BCP was fabricated via solid state reaction. Evaluation of BCP crystalline structure confirmed the presence of tricalcium phosphate (TCP) and HA phases. The morphology of calcium phosphate powders and the paste showed fine particles and homogeneous distribution, respectively. Consistency, injectability, washout and the rheology behavior of pastes were evaluated too. According to the results, the pastes consisted of considerable values of calcium phosphate content (about 65%) and injectability of 84% and 91% with acceptable degradation in PBS, were found for Gel/0.4% CMC and Gel/1.2% Alg pastes, respectively. It could be concluded that the addition of carbohydrate polymers (CMC and Alg) to the formulation of samples could be an effective way to adjust the final performance of the hybrid injectable bone pastes. © 2019 Elsevier Ltd
Related Docs
1. 3D–Printed Biphasic Calcium Phosphate Scaffolds Coated With an Oxygen Generating System for Enhancing Engineered Tissue Survival, Materials Science and Engineering C (2018)
2. Preparation and Characterization of Cardamom Extract-Loaded Gelatin Nanoparticles As Effective Targeted Drug Delivery System to Treat Glioblastoma, Reactive and Functional Polymers (2017)