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Conductive Biomaterials As Nerve Conduits: Recent Advances and Future Challenges Publisher



Zarrintaj P1 ; Zangene E2 ; Manouchehri S1 ; Amirabad LM3 ; Baheiraei N4 ; Hadjighasem MR5 ; Farokhi M6 ; Ganjali MR7, 8 ; Walker BW9 ; Saeb MR7 ; Mozafari M10 ; Thomas S11 ; Annabi N9
Authors
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Authors Affiliations
  1. 1. School of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, 74078, OK, United States
  2. 2. Department of Bioinformatics, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran
  3. 3. Departments of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, 53233, WI, United States
  4. 4. issue Engineering and Applied Cell Sciences Division, Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  5. 5. Brain and Spinal Cord Injury Research Center, Imam Khomeinin Hospital, Blv Keshavarz, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  7. 7. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran
  8. 8. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Chemical and Biomolecular Engineering, University of California – Los Angeles, Los Angeles, 90095, CA, United States
  10. 10. Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran
  11. 11. School of Chemical Sciences, M G University, Kottayam, 686560, Kerala, India

Source: Applied Materials Today Published:2020


Abstract

Millions of people around the world are in distress due to neurodegenerative disorders. There have been continued attempts to design biomaterial-based therapies for the regeneration of dysfunctional neural tissues, mainly damaged peripheral nerve and spinal cord. The development of nerve guidance channels, where the distal and proximal end of a damaged nerve is sutured to an artificial conduit, has been one main strategy to treat damaged nerves. Different types of biomaterials have been utilized for fabricating the functional nerve conduits with the capability to stimulate the cellular function. Due to their intrinsic electrical properties, conductive materials revealed promising features for promoting regeneration of peripheral nerve injuries. This review article aims to critically summarize the recent advances and challenges toward the development of nerve conduits based on conductive materials and their future clinical applications. © 2020 Elsevier Ltd
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