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Further Numerical Analyses on the Solubility of Diazepam in Aqueous Tert-Butanol Mixtures Publisher



Jouyban A1, 2 ; Acree WE3 ; Martinez F4
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Chemistry, University of North Texas, Denton, TX, United States
  4. 4. Grupo De Investigaciones Farmaceutico-Fisicoquimicas, Departamento De Farmacia, Universidad Nacional De Colombia, Bogota, Colombia

Source: Physics and Chemistry of Liquids Published:2021


Abstract

The mole fraction equilibrium solubility of diazepam in some {tert-butanol (1) + water (2)} mixtures at several temperatures has been correlated by means of the Jouyban–Acree model and also to evaluate the preferential solvation of this compound by the mixtures components. By using the inverse Kirkwood-Buff integrals method apparently is observed that diazepam is preferentially solvated by water in water-rich and tert-butanol-rich mixtures but preferentially solvated by tert-butanol in mixtures of similar proportions of both solvents. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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