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Latest Findings on the Effects of Gold Nanoparticles on the Storage Quality of Blood Products (2011-2022) - a Narrative Review Publisher Pubmed



Mehrizi TZ1 ; Rezayat SM2 ; Shahmabadi HE3
Authors
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Authors Affiliations
  1. 1. Vaccine Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Source: Current Drug Delivery Published:2024


Abstract

A wide range of challenges are faced during the storage of blood products, including storage lesions, contamination that must be removed, and cell and protein damage due to chemicals and UV exposure. The enhancement of stability exhibited by gold nanoparticles (GNPs) is a notable advantage of these nanoparticles for the storage of blood products. The results of our review of articles from 2011 to 2022 discussing the effect of GNPs on blood products revealed that in RBCs, the dose, concentration, amount, and surface charge of GNPs significantly affect their compatibility. Purified GNPs were compatible with RBCs. Negatively charged GNPs with smaller diameters at lower concentrations were more compatible. However, in the plasma product, the nanoparticle surface modification with different agents showed greater compatibility. PEGylated nanospheres and GNPs exhibited higher albumin conformational stability than those coated with cetyltrimethylammonium bromide and rods. In the platelet product, smaller GNPs and high GNP concentrations induce platelet aggregation. PEGylation increased the platelet compatibility of GNP. The combination of GNPs with human fibrinogen and clopidogrel prevented clot formation. Finally, the findings of this investigation demonstrate that GNPs are contingent on their surface charge, dosage, and concentration. © 2024 Bentham Science Publishers.
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