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The Bio-Interface Between Functionalized Au Nr@Go Nanoplatforms With Protein Corona and Their Impact on Delivery and Release System Publisher Pubmed



Assali A1 ; Razzazan S2 ; Akhavan O3 ; Mottaghitalab F1 ; Adeli M4 ; Atyabi F1
Authors
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Authors Affiliations
  1. 1. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 1417614411, Tehran, Iran
  2. 2. Department of Electrical Engineering, Amirkabir University of Technology, P.O.Box 1591634311, Tehran, Iran
  3. 3. Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  4. 4. Department of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie University Berlin, Berlin, 14195, Germany

Source: Colloids and Surfaces B: Biointerfaces Published:2019


Abstract

Interaction of nanoplatforms with biomolecules in biological fluids alters nanoplatforms approach to target tissue and deliver their cargo. Here in, three nanoplatforms were utilized as a carrier to detect the effects of subsequent biomolecules on gene delivery using NIR thermal therapy. Nanoplatforms included; graphene oxide coated gold nanorods (NR@GO), PEGylated NR@GO (NR@GO-PEG) and poly L arginine functionalized NR@GO-PEG (NR@GO-PEG-PLArg). Results indicated that incubation of nanoplatforms in different concentrations of human plasma induced the evolution of layer of proteins (corona) with different thickness on the surface of nanoplatforms. Protein corona decreased the surface charge and optical properties of nanoplatforms. Corona subunits of ITIH, HAS and APOs protein family were extracted from NR@GO-PEG-PLArg surface that play a major role in cellular internalization of nanoplatforms. Moreover, NR@GO-PEG-PLArg remarkably targeted the cancer cells due to uncovered long linear chains of targeting agent (PLArg). The process of gene release and activating apoptotic pathway were enhanced by NIR thermal therapy, which could disrupt the electrostatic interactions and release the protein corona and genes from the surface of nanoplatforms. In conclusion, modification of nanoplatforms with targeting agents could alter the composition of corona toward well interaction with cell and deliver the therapeutic agent. © 2018 Elsevier B.V.
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