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Encapsulation of Bioactives Within Electrosprayed Κ-Carrageenan Nanoparticles Publisher Pubmed



Fani N1 ; Enayati MH1 ; Rostamabadi H2 ; Falsafi SR3
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Authors Affiliations
  1. 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: Carbohydrate Polymers Published:2022


Abstract

In this study, an electrospray synthesis approach was utilized in which a solution mixture of a sensitive bioactive agent, D-limonene (DL, R-(+)-Limonene), and a nature-inspired polymer, κ-carrageenan (κC) was applied to design DL-κC nanoparticles (NPs) in a one step process. The engineered DL-κC NPs displayed spherical morphology and the maximum encapsulation efficiency of NPs was about 97 % by altering the mass ratio of DL to κC. The developed DL-κC NPs showed a pH-dependent release manner in vitro. Both photostability and thermostability of DL were promoted by increasing the κC concentration, and >85 % of the original DL could be preserved following 120 min of UV-light exposure in the NPs with 0.5 % κC. The results demonstrated that electrosprayed κC NPs are promising candidates for the design of high-loading pH-sensitive NPs for encapsulation of highly sensitive bioactive agents. © 2022
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