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Leishmanicidal Activities of Biosynthesized Baco3 (Witherite) Nanoparticles and Their Biocompatibility With Macrophages Publisher Pubmed



Hashemi N1, 2 ; Alijani HQ3 ; Mousazadeh F1 ; Rahi S1 ; Darijani S1 ; Sharifi F4 ; Khalili H2 ; Iravani S5 ; Borhani F6 ; Zafarnia N1 ; Khatami M1, 7
Authors
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Authors Affiliations
  1. 1. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  2. 2. School of Medicine, Bam University of Medical Sciences, Bam, Iran
  3. 3. Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran
  4. 4. Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Bioprocess and Biosystems Engineering Published:2021


Abstract

The aim of this study was cost-effective and greener synthesis of barium carbonate (BaCO3 or witherite) nanoparticles with economic importance, and to evaluate their therapeutic potentials and biocompatibility with immune cells. Barium carbonate nanoparticles were biosynthesized using black elderberry extract in one step with non-toxic precursors and simple laboratory conditions; their morphologies and specific structures were analyzed using field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX). The therapeutic capabilities of these nanoparticles on the immune cells of murine macrophages J774 and promastigotes Leishmania tropica were evaluated. BaCO3 nanoparticles with IC50 = 46.6 µg/mL were more effective than negative control and glucantium (positive control) in reducing promastigotes (P < 0.01). Additionally, these nanoparticles with a high value of cytotoxicity concentration 50% (CC50) were less toxic to macrophage cells than glucantime; however, they were significantly different at high concentrations compared to the negative control. Graphic abstract: [Figure not available: see fulltext.]. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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