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Fabrication, Characterization, and Drug Release Study of Vitamin C–Loaded Alginate/Polyethylene Oxide Nanofibers for the Treatment of a Skin Disorder Publisher



Rezaei S1 ; Valipouri A1 ; Hosseini Ravandi SA1 ; Kouhi M2, 3 ; Ghasemi Mobarakeh L1
Authors
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Authors Affiliations
  1. 1. Department of Textile Engineering, Isfahan University of Technology, Isfahan, 8415683111, Iran
  2. 2. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 8415683111, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Polymers for Advanced Technologies Published:2019


Abstract

Pigmented purpuric dermatosis (PPD) is a skin disorder mainly seen in the lower limbs. The nanofibrous web has been shown to be an appropriate alternative for the treatment of skin diseases as a drug delivery vehicle. In this study, sodium alginate (SA)/polyethylene oxide (PEO) nanofibers containing vitamin C (VC) were fabricated using both blended electrospinning and core/shell electrospinning. The resultant nanofibers were characterized using Fourier transform infrared spectroscopy and scanning electron microscopy. Enhancing the VC content resulted in increasing the nanofibers diameter. Also, the degradation rate and drug release were investigated. Drug release was evaluated using the in vitro dissolution and permeation method. The degradation rate and the drug release of the core/shell nanofibers were found to be lower than those of the blended nanofibers. The drug release of the extended nanofibers followed a different pattern, indicating that the extension of the nanofibers could be a promising way to control the drug release. © 2019 John Wiley & Sons, Ltd.
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