Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Impact of Magnesium Sulfate Therapy in Improvement of Renal Functions in High Fat Diet-Induced Diabetic Rats and Their Offspring
Mohammadreza Sharifi
Mohammadreza Sharifi

Professor of Molecular Medicine

Department of Genetics and Molecular Biology, School of Medicine

Pediatric Inherited Diseases Research Center

Research Institute for Primordial Prevention of Non-communicable Disease

Isfahan University of Medical Sciences

All Documents
1. Decreased Expression of Hsa-Mir-142-3P and Hsa-Mir-155-5P in Common Variable Immunodeficiency and Involvement of Their Target Genes and Biological Pathways, Allergologia et Immunopathologia (2025)
2. Differential Expression and Pathological Implications of Linc01089 and Linc01578 in Acute Myeloid Leukemia, Gene Reports (2025)
3. Effects of Chronic Empathic Stress on Synaptic Efficacy, As Well As Short-Term and Long-Term Plasticity at the Schaffer Collateral/Commissural– Ca1 Synapses in the Dorsal Hippocampus of Rats, Metabolic Brain Disease (2025)
4. Gallic Acid Ameliorates Lps-Induced Memory Decline by Modulating Nf-Κb, Tnf-Α, and Caspase 3 Gene Expression and Attenuating Oxidative Stress and Neuronal Loss in the Rat Hippocampus, Metabolic Brain Disease (2025)
5. Single Cell Rna Sequencing Improves the Next Generation of Approaches to Aml Treatment: Challenges and Perspectives, Molecular Medicine (2025)
6. The Role of Mir-16 and Mir-34A Family in the Regulation of Cancers: A Review, Heliyon (2025)
7. Assessment of Axonal Injury in Multiple Sclerosis: Combined Analysis of Serum Light-Chain Neurofilaments and Diffusion Tensor Imaging, BMJ Neurology Open (2024)
8. Crocin Improves Cognitive Impairment in Lps-Treated Rats Through Anti-Apoptotic, Anti-Inflammatory, and Antioxidant Activities, Molecular Neurobiology (2024)
9. Effects of Chronic Empathic and Reversed Empathic Stress on Anxiety-Like Behaviors in Male Rats; [ثرات استرس مزمن همدلی و همدلی معکوس بر رفتارهای شبه اضطرابی در راتهای نر], Journal of Isfahan Medical School (2024)
10. Effects of Chronic Social Equality and Inequality Conditions on Passive Avoidance Memory and Ptsd-Like Behaviors in Rats Under Chronic Empathic Stress, International Journal of Neuroscience (2024)
11. Exercise-Activated Hepatic Autophagy Combined With Silymarin Is Associated With Suppression of Apoptosis in Rats Subjected to Dexamethasone Induced- Fatty Liver Damage, Molecular Biology Reports (2024)
12. Msc-Derived Exosomes Enhance the Anticancer Activity of Drugs in 3D Spheroid of Breast Cancer Cells, Journal of Drug Delivery Science and Technology (2024)
13. Retraction Notice to “The Therapeutic Potential of Human Adipose-Derived Mesenchymal Stem Cells Producing Cxcl10 in a Mouse Melanoma Lung Metastasis Model” [Cancer Lett. 419 (2018) 30–39, (S030438351830051x), (10.1016/J.Canlet.2018.01.029)], Cancer Letters (2024)
14. Retraction Notice to “The Therapeutic Potential of Human Adipose-Derived Mesenchymal Stem Cells Producing Cxcl10 in a Mouse Melanoma Lung Metastasis Model” [Cancer Lett. 419 (2018) 30–39, (S030438351830051x), (10.1016/J.Canlet.2018.01.029)], Cancer Letters (2024)
15. The Effect of Long-Term Magnesium Treatment on Changes in Hepatic Autophagic and Apoptotic Ability of Type 2 Diabetic Female Rats and Their Offspring, Gene Reports (2024)
16. The Nlrp3 Inflammasome: Mechanisms of Activation, Regulation, and Role in Diseases, International Reviews of Immunology (2024)
17. Alleviation of Cholestatic Liver Injury and Intestinal Permeability by Lubiprostone Treatment in Bile Duct Ligated Rats: Role of Intestinal Fxr and Tight Junction Proteins Claudin-1, Claudin-2, and Occludin, Naunyn-Schmiedeberg's Archives of Pharmacology (2023)
18. Effects of Glucose on the Proliferation of Human Umbilical Cord Blood Hematopoietic Stem Cells, Cell and Tissue Banking (2023)
19. Effects of Hsa-Pir-32877 Suppression With Antisense Lna Gapmers on the Proliferation and Apoptosis of Human Acute Myeloid Leukemia Cells, International Journal of Molecular and Cellular Medicine (2023)
20. Engaging Stemness Improves Cancer Immunotherapy, Cancer Letters (2023)
21. Gamma-Aminobutyric Acid Attenuates Insulin Resistance in Type 2 Diabetic Patients and Reduces the Risk of Insulin Resistance in Their Offspring, Koomesh (2023)
22. Impact of Magnesium Sulfate Therapy in Improvement of Renal Functions in High Fat Diet-Induced Diabetic Rats and Their Offspring, Scientific Reports (2023)
23. Knockdown of Sirlnt by Antisense Lna Gapmers and Evaluation of Its Inhibitory Effect on Proliferation and Apoptosis in Mcf7 Cell Line, Indian Journal of Gynecologic Oncology (2023)
24. Relationship Between Long Non-Coding Rna Malat1 and Hotair Expression With Sperm Parameters, Dna and Malondialdehyde Levels in Male Infertility, Tissue and Cell (2023)
25. Assessment of Adiponectin and Sperm Function Parameters in Obese and Non-Obese: A Comprehensive Study, Cell Journal (2022)
26. Combination Therapy With Gaba and Mgso4improves Insulin Sensitivity in Type 2 Diabetic Rat, International Journal of Endocrinology (2022)
27. Correlation of Obesity and Serum Vitamin D Levels With Sperm Dna Integrity, Sperm Quality, and Sperm Viability in Normozoospermia Men, Advanced Biomedical Research (2022)
28. Evaluation of the Relationship Between Axon Injury and Clinical Symptoms in Patients With Multiple Sclerosis Using Diffusion Tensor Mri Imaging; [بررسی ارتباط آسیب آکسون با علایم بالینی در بیماران مبتلا به مالتیپل اسکلروزیس Mri با استفاده از تصویربرداري انتشار تانسوري], Tehran University Medical Journal (2022)
29. Evaluation of the Relationship Between Axon Injury and Clinical Symptoms in Patients With Multiple Sclerosis Using Diffusion Tensor Mri Imaging; [بررسی ارتباط آسیب آکسون با علایم بالینی در بیماران مبتلا به مالتیپل اسکلروزیس Mri با استفاده از تصویربرداري انتشار تانسوري], Tehran University Medical Journal (2022)
30. Investigation of the Expression of P-Element-Induced Wimpy Testis-Interacting Rnas in Human Acute Myeloid Leukemia, Meta Gene (2022)
31. Investigation of the Relationship Between Mir-33A, Mir-122, Erythrocyte Membrane Fatty Acids Profile, and Serum Lipids With Components of Metabolic Syndrome in Type 2 Diabetic Patients, Research in Pharmaceutical Sciences (2022)
32. S100a8 Inhibition in Leukemic Lymphoblasts Induces Sensitivity to Chemotherapy and Inhibition of Disease Relapse, Medical Oncology (2022)
33. The Role of Pancreas to Improve Hyperglycemia in Stz-Induced Diabetic Rats by Thiamine Disulfide, Nutrition and Diabetes (2022)
34. Therapeutic Potential of Antimicrobial Peptides for Wound Healing, International Journal of Peptide Research and Therapeutics (2022)
35. Downregulation of Mir100hg Induces Apoptosis in Human Megakaryoblastic Leukemia Cells, Indian Journal of Hematology and Blood Transfusion (2021)
36. Evaluating the Effect of Ovarian Stimulation and Exogenous Progesterone on Cd31-Positive Cell Density, Vegf Protein, and Mir-17-5P Expression of Endometrium Immediately Before Implantation, Biomedicine and Pharmacotherapy (2021)
37. Gaba Administration Improves Liver Function and Insulin Resistance in Offspring of Type 2 Diabetic Rats, Scientific Reports (2021)
38. Gamma-Aminobutyric Acid Attenuates Insulin Resistance in Type 2 Diabetic Patients and Reduces the Risk of Insulin Resistance in Their Offspring, Biomedicine and Pharmacotherapy (2021)
39. Insulin Resistance and the Role of Gamma-Aminobutyric Acid, Journal of Research in Medical Sciences (2021)
40. Knockdown of Sox12 Expression Induced Apoptotic Factors and Is Associated With Twist1 and Ctnnb1 Expression in Human Acute Myeloid Leukemia Cells, International Journal of Molecular and Cellular Medicine (2021)
41. Magnesium Sulfate Improves Insulin Resistance in High Fat Diet Induced Diabetic Parents and Their Offspring, European Journal of Pharmacology (2021)
42. Ovarian Stimulation and Exogenous Progesterone Affect the Endometrial Mir-16-5P, Vegf Protein Expression, and Angiogenesis, Microvascular Research (2021)
43. The Correlation Between Sperm Dna Fragmentation and the Expression of Long Non-Coding Rna Hotair in Infertile Men, Journal of Isfahan Medical School (2021)
44. Association Between Polymorphisms in Microrna Seed Region and Warfarin Stable Dose, Postgraduate Medical Journal (2020)
45. Association Between Polymorphisms in Microrna Seed Region and Warfarin Stable Dose, Postgraduate Medical Journal (2020)
46. Degradation of Hox Transcript Antisense Rna Provoked Apoptosis and Necrosis in Human Ovarian Cancer Cells, Indian Journal of Gynecologic Oncology (2020)
47. Degradation of Hox Transcript Antisense Rna Provoked Apoptosis and Necrosis in Human Ovarian Cancer Cells, Indian Journal of Gynecologic Oncology (2020)
48. Lna Inhibitor in Microrna Mir-23B As a Potential Anti-Proliferative Option in Human Hepatocellular Carcinoma, Journal of Gastrointestinal Cancer (2020)
49. Micrornas: Key Modulators of Disease-Modifying Therapies in Multiple Sclerosis : Pancreatic Cancer Is One of the Lethal Malignant Tumours in the World.In This Study, We Investigated the Car T-Cell Therapy of Pancreatic Cancer, International Reviews of Immunology (2020)
50. Reduce Proliferation of Human Bone Marrow Cells From Acute Myeloblastic Leukemia With Minimally Differentiation by Blocking Lncrna Pvt1, Clinical and Translational Oncology (2020)
51. Retraction Note: Blockage of Mir-92A-3P With Locked Nucleic Acid Induces Apoptosis and Prevents Cell Proliferation in Human Acute Megakaryoblastic Leukemia (Cancer Gene Therapy, (2016), 23, 1, (29-35), 10.1038/Cgt.2015.63), Cancer Gene Therapy (2020)
52. Association Between Four Microrna Binding Siterelated Polymorphisms and the Risk of Warfarininduced Bleeding Complications, EXCLI Journal (2019)
53. Association Between Four Microrna Binding Siterelated Polymorphisms and the Risk of Warfarininduced Bleeding Complications, EXCLI Journal (2019)
54. Birc5 Gene Disruption Via Crispr/Cas9n Platform Suppress Acute Myelocytic Leukemia Progression, Iranian Biomedical Journal (2019)
55. Blockage of Hotair Reduced Cell Proliferation in Human Ovarian Cancer Cells Through Upregulation of Akt2, Indian Journal of Gynecologic Oncology (2019)
56. Blockage of Hotair Reduced Cell Proliferation in Human Ovarian Cancer Cells Through Upregulation of Akt2, Indian Journal of Gynecologic Oncology (2019)
57. Inhibition of Herpes Simplex Virus Type 1 Replication by Novel Hsa-Mir-7704 in Vitro, Research in Pharmaceutical Sciences (2019)
58. Knockdown of Long Noncoding Rna Plasmacytoma Variant Translocation 1 With Antisense Locked Nucleic Acid Gapmers Exerts Tumor-Suppressive Functions in Human Acute Erythroleukemia Cells Through Downregulation of C-Myc Expression, Cancer Biotherapy and Radiopharmaceuticals (2019)
59. Retraction Note To: Inhibition of Microrna Mir-92A Induces Apoptosis and Inhibits Cell Proliferation in Human Acute Promyelocytic Leukemia Through Modulation of P63 Expression (Molecular Biology Reports, (2014), 41, 5, (2799-2808), 10.1007/S11033-014-3134-5), Molecular Biology Reports (2019)
60. Retraction Note To: Inhibition of Microrna Mir-92A Induces Apoptosis and Inhibits Cell Proliferation in Human Acute Promyelocytic Leukemia Through Modulation of P63 Expression (Molecular Biology Reports, (2014), 41, 5, (2799-2808), 10.1007/S11033-014-3134-5), Molecular Biology Reports (2019)
61. The Effect of Medicinal Plant Extracts on Helminthes: A Systematic Review, Journal of Isfahan Medical School (2019)
62. The Role of Microrna-30A and Downstream Snail1 on the Growth and Metastasis of Melanoma Tumor, Iranian Journal of Basic Medical Sciences (2019)
63. Antiproliferative Effect of Upregulation of Hsa-Let-7C-5P in Human Acute Erythroleukemia Cells, Cytotechnology (2018)
64. Apoptosis Induction in Acute Promyelocytic Leukemia Cells Through Upregulation of Cebpα by Mir-182 Blockage, Molecular Biology Research Communications (2018)
65. Crispr/Cas9, a New Approach to Successful Knockdown of Abcb1/P-Glycoprotein and Reversal of Chemosensitivity in Human Epithelial Ovarian Cancer Cell Line, Iranian Journal of Basic Medical Sciences (2018)
66. Effect of Magnesium Sulfate Administration to Improve Insulin Resistance in Type 2 Diabetes Animal Model: Using the Hyperinsulinemic-Euglycemic Clamp Technique, Fundamental and Clinical Pharmacology (2018)
67. Evaluation of the Effect of Tim-3 Suppression by Mir-498 and Its Effect on Apoptosis and Proliferation Rate of Hl-60 Cell Line, Pathology Research and Practice (2018)
68. Evaluation of the Effects A2b Adenosine Receptor-Agonist (Bay 60–6583) in Induction of Apoptosis in Achn Renal Cancer Cell Line, Journal of Isfahan Medical School (2018)
69. Exosomal Mirnas As Novel Cancer Biomarkers: Challenges and Opportunities, Journal of Cellular Physiology (2018)
70. Gaba Dramatically Improves Glucose Tolerance in Streptozotocin-Induced Diabetic Rats Fed With High-Fat Diet, European Journal of Pharmacology (2018)
71. Inducing Apoptosis and Decreasing Cell Proliferation in Human Acute Promyelocytic Leukemia Through Regulation Expression of Casp3 by Let-7A-5P Blockage, Indian Journal of Hematology and Blood Transfusion (2018)
72. Induction of Apoptosis and Necrosis in Human Acute Erythroleukemia Cells by Inhibition of 47Tlong Non-Coding Rna Pvt1, Molecular Biology Research Communications (2018)
73. Locked Nucleic Acid -Anti- Let-7A Induces Apoptosis and Necrosis in Macrophages Infected With Leishmania Major, Microbial Pathogenesis (2018)
74. Mir-185 Enhances Radiosensitivity of Colorectal Cancer Cells by Targeting Igf1r and Igf2, Biomedicine and Pharmacotherapy (2018)
75. Mir-20A Inhibition Using Locked Nucleic Acid (Lna) Technology and Its Effects on Apoptosis of Human Macrophages Infected by Toxoplasma Gondii Rh Strain, Microbial Pathogenesis (2018)
76. Molecular Mechanisms of Drug Resistance in Ovarian Cancer, Journal of Cellular Physiology (2018)
77. Non-Invasive Diagnosis of Early-Onset Coronary Artery Disease Based on Cell Type-Specific Gene Expression Analyses, Biomedicine and Pharmacotherapy (2018)
78. Non-Invasive Diagnosis of Early-Onset Coronary Artery Disease Based on Cell Type-Specific Gene Expression Analyses, Biomedicine and Pharmacotherapy (2018)
79. Semaphorin-3A As an Immune Modulator Is Suppressed by Microrna-145-5P, Cell Journal (2018)
80. The Effect of Erythropoietin on Neuronal Apoptosis in Hippocampal Dentate Gyrus in Streptozotocin-Induced Alzheimer’S Disease in Rats, Journal of Isfahan Medical School (2018)
81. The Effect of Long Non-Coding Rna Pvt1 Inhibition by Antisense Lna Gapmers Technology on Proliferation of Human Acute Erythroleukemia Cells, Journal of Isfahan Medical School (2018)
82. The Effect of Mir-200C Inhibition on Chemosensitivity (5- Fluorouracil) in Colorectal Cancer, Pathology and Oncology Research (2018)
83. The Effect of Mirna Mimic Hsa-Mir-7704 on In-Vitro Replication of Herpes Simplex Virus Type 1, Journal of Isfahan Medical School (2018)
84. The Therapeutic Potential of Human Adipose-Derived Mesenchymal Stem Cells Producing Cxcl10 in a Mouse Melanoma Lung Metastasis Model, Cancer Letters (2018)
85. The Therapeutic Potential of Human Adipose-Derived Mesenchymal Stem Cells Producing Cxcl10 in a Mouse Melanoma Lung Metastasis Model, Cancer Letters (2018)
86. Apoptosis-Inducing and Antiproliferative Effect by Inhibition of Mir-182-5P Through the Regulation of Casp9 Expression in Human Breast Cancer, Cancer Gene Therapy (2017)
87. Circulating Exosomes and Exosomal Micrornas As Biomarkers in Gastrointestinal Cancer, Cancer Gene Therapy (2017)
88. Current Status and Perspectives Regarding Lna-Anti-Mir Oligonucleotides and Microrna Mir-21 Inhibitors As a Potential Therapeutic Option in Treatment of Colorectal Cancer, Journal of Cellular Biochemistry (2017)
89. Effects of Stress on Serum and Hippocampal Il-1Β and Glucose Levels As Well As Retention in Rats, Indian Journal of Physiology and Pharmacology (2017)
90. Inducing Apoptosis and Decreases Cell Proliferation in Human Breast Cancer Cells Through Mir-182-5P Blockage Caused by Locked Nucleic Acid, Journal of Isfahan Medical School (2017)
91. Inducing Cell Proliferative Prevention in Human Acute Promyelocytic Leukemia by Mir-182 Inhibition Through Modulation of Casp9 Expression, Biomedicine and Pharmacotherapy (2017)
92. Inhibition of Microrna Mir-222 With Lna Inhibitor Can Reduce Cell Proliferation in B Chronic Lymphoblastic Leukemia, Indian Journal of Hematology and Blood Transfusion (2017)
93. Inhibition of Microrna-21 Via Locked Nucleic Acid-Anti-Mir Suppressed Metastatic Features of Colorectal Cancer Cells Through Modulation of Programmed Cell Death 4, Tumor Biology (2017)
94. Kefir: A Powerful Probiotics With Anticancer Properties, Medical Oncology (2017)
95. Stress Biomarker Responses to Different Protocols of Forced Exercise in Chronically Stressed Rats, Journal of Bodywork and Movement Therapies (2017)
96. Blockage of Mir-92A-3P With Locked Nucleic Acid Induces Apoptosis and Prevents Cell Proliferation in Human Acute Megakaryoblastic Leukemia, Cancer Gene Therapy (2016)
97. Kefir Induces Apoptosis and Inhibits Cell Proliferation in Human Acute Erythroleukemia, Medical Oncology (2016)
98. Locked Nucleic Acid Anti-Mir-21 Inhibits Cell Growth and Invasive Behaviors of a Colorectal Adenocarcinoma Cell Line: Lna-Anti-Mir As a Novel Approach, Cancer Gene Therapy (2016)
99. Locked Nucleic Acid Inhibits Mir-92A-3P in Human Colorectal Cancer, Induces Apoptosis and Inhibits Cell Proliferation, Cancer Gene Therapy (2016)
100. The Effect of Beta Interferon on the Expression of Mir-145 in Patients With Multiple Sclerosis, Journal of Isfahan Medical School (2016)
101. The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal Memory Mediators in Stressed Rats, Malaysian Journal of Medical Sciences (2016)
102. Degradation of Mir-21 Induces Apoptosis and Inhibits Cell Proliferation in Human Hepatocellular Carcinoma, Cancer Gene Therapy (2015)
103. Effect of Forced Exercise and Exercise Withdrawal on Memory, Serum and Hippocampal Corticosterone Levels in Rats, Experimental Brain Research (2015)
104. Effects of Different Timing of Stress on Corticosterone, Bdnf and Memory in Male Rats, Physiology and Behavior (2015)
105. Preventive and Therapeutic Effect of Treadmill Running on Chronic Stress-Induced Memory Deficit in Rats, Journal of Bodywork and Movement Therapies (2015)
106. Effect of Testosterone on Cisplatin-Induced Nephrotoxicity in Surgically Castrated Rats, Nephro-Urology Monthly (2014)
107. Inhibition of Microrna Mir-92A Induces Apoptosis and Inhibits Cell Proliferation in Human Acute Promyelocytic Leukemia Through Modulation of P63 Expression, Molecular Biology Reports (2014)
108. Erythropoietin Improves Spatial Learning and Memory in Streptozotocin Model of Dementia, Pathophysiology (2013)
109. Inhibition of Microrna Mir-92A Inhibits Cell Proliferation in Human Acute Promyelocytic Leukemia; [Mikrorna Mir-92A Inhibisyonu Insan Akut Promyelositik Losemide Hucre Proliferasyonunu Inhibe Eder], Turkish Journal of Hematology (2013)
110. Is There Any Association of Anxiety-Depressive Symptoms With Vascular Endothelial Function or Systemic Inflammation?, Journal of Research in Medical Sciences (2013)
111. The Effect of Chronic Hyperthyroidism and Restored Euthyroid State by Methimazole Therapy in Rat Small Mesenteric Arteries, European Journal of Pharmacology (2013)
112. The Effect of Synchronized Forced Running With Chronic Stress on Short, Mid and Long- Term Memory in Rats, Asian Journal of Sports Medicine (2013)
113. The Effect of Synchronized Running Activity With Chronic Stress on Passive Avoidance Learning and Body Weight in Rats, International Journal of Preventive Medicine (2013)
114. Coronary Angiogenesis During Experimental Hypertension: Is It Reversible?, Journal of Research in Medical Sciences (2011)
115. Effect of Hypertension and Its Reverse on Serum Nitric Oxide Concentration and Vascular Permeability in Two-Kidney One-Clip Hypertensive Rats, General Physiology and Biophysics (2011)
116. Effects of Diabetes on Myocardial Capillary Density and Serum Angiogenesis Biomarkers in Male Rats, Clinics (2011)
117. Restoration of Angiogenesis by Enalapril in Diabetic Hindlimb Ischemc Rats, Biomedical Papers (2011)
118. The Effect of Maintenance and Reversal of Doca-Salt Hypertension on Extravasation of Macromolecules and Serum Nitric Oxide Concentration in Male Rats, Pathophysiology (2011)
119. The Effects of Erythropoietin on Learning and Memory in Rats With Alzheimer’S Disease, Journal of Isfahan Medical School (2011)
120. Effects of Treadmill Running on Extracellular Basal Levels of Glutamate and Gaba at Dentate Gyrus of Streptozotocin-Induced Diabetic Rats, Journal of Research in Medical Sciences (2010)
121. Treadmill Running Improves Long-Term Potentiation (Ltp) Defects in Streptozotocin-Induced Diabetes at Dentate Gyrus in Rats, Pathophysiology (2010)
122. Determination of the Extracellular Basal Levels of Glutamate and Gaba at Dentate Gyrus of Streptozotocin-Induced Diabetic Rats, Pathophysiology (2009)
123. Effects of Treadmill Running on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats, Neuroscience Letters (2009)
124. Treadmill Exercise Reduces Self-Administration of Morphine in Male Rats, Pathophysiology (2009)
125. Effects of Treadmill Running on Short-Term Pre-Synaptic Plasticity at Dentate Gyrus of Streptozotocin-Induced Diabetic Rats, Brain Research (2008)
126. Effects of Angiotensin Ii and Captopril on Rewarding Propreties of Morphine, Indian Journal of Experimental Biology (2007)
127. Effects of Dopamine Administration on Anxiety in Male Rat, Journal of Isfahan Medical School (2007)
128. The Effects of Angiotensin Ii and Captopril on Expression of Morphine Withdrawal Signs in Rat, Iranian Journal of Pharmaceutical Research (2007)