Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Extracellular Micro/Nanovesicles Rescue Kidney From Ischemia-Reperfusion Injury Publisher Pubmed



Farzamfar S1 ; Hasanpour A2 ; Nazeri N2 ; Razavi H1 ; Salehi M3, 4 ; Shafei S5 ; Nooshabadi VT6 ; Vaez A1 ; Ehterami A7 ; Sahrapeyma H8 ; Ai J1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  4. 4. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  5. 5. Department of Molecular Medicine, School of Advanced Technologies in Medicine, International Campus of Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Applied Cell Sciences, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Department of Mechanical and Aerospace Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  8. 8. Department of Biomaterial Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

Source: Journal of Cellular Physiology Published:2019


Abstract

Acute renal failure (ARF) is a clinical challenge that is highly resistant to treatment, and its high rate of mortality is alarming. Ischemia–reperfusion injury (IRI) is the most common cause of ARF. Especially IRI is implicated in kidney transplantation and can determine graft survival. Although the exact pathophysiology of renal IRI is unknown, the role of inflammatory responses has been elucidated. Because mesenchymal stromal cells (MSCs) have strong immunomodulatory properties, they are under extensive investigation as a therapeutic modality for renal IRI. Extracellular vesicles (EVs) play an integral role in cell-to-cell communication. Because the regenerative potential of the MSCs can be recapitulated by their EVs, the therapeutic appeal of MSC-derived EVs has dramatically increased in the past decade. Higher safety profile and ease of preservation without losing function are other advantages of EVs compared with their producing cells. In the current review, the preliminary results and potential of MSC-derived EVs to alleviate kidney IRI are summarized. We might be heading toward a cell-free approach to treat renal IRI. © 2018 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. The Extracellular Vesicles-Derived From Mesenchymal Stromal Cells: A New Therapeutic Option in Regenerative Medicine, Journal of Cellular Biochemistry (2018)
2. Exosomes As a Novel Cell-Free Therapeutic Approach in Gastrointestinal Diseases, Journal of Cellular Physiology (2019)
3. Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration, Advances in Experimental Medicine and Biology (2018)
4. Mesenchymal Stem Cell-Derived Extracellular Vesicles: Novel Frontiers in Regenerative Medicine, Stem Cell Research and Therapy (2018)
5. The Relationship Between Molecular Content of Mesenchymal Stem Cells Derived Exosomes and Their Potentials: Opening the Way for Exosomes Based Therapeutics, Biochimie (2019)
6. Extracellular Vesicles Biogenesis, Isolation, Manipulation and Genetic Engineering for Potential in Vitro and in Vivo Therapeutics: An Overview, Frontiers in Bioengineering and Biotechnology (2022)
7. Mesenchymal Stem Cell-Derived Exosomes: A New Therapeutic Approach to Osteoarthritis?, Stem Cell Research and Therapy (2019)
8. Mesenchymal Stem/Stromal Cell-Derived Exosomes in Regenerative Medicine and Cancer; Overview of Development, Challenges, and Opportunities, Stem Cell Research and Therapy (2021)
Experts (# of related papers)
View all Related Experts
Somayeh Ebrahimi Barough (5)
Hamid Reza Mirzaei (4)
Other Related Docs
9. Effect of Mesenchymal Stem Cells-Derived Exosomes on Tumor Microenvironment: Tumor Progression Versus Tumor Suppression, Journal of Cellular Physiology (2019)
10. Extracellular Vesicles in Bone and Periodontal Regeneration: Current and Potential Therapeutic Applications, Cell and Bioscience (2021)
11. Effect of Photobiomodulation on Structure and Function of Extracellular Vesicle Secreted From Mesenchymal Stem Cells, Photochemistry and Photobiology (2022)
12. Mesenchymal Stem Cell-Derived Extracellular Vesicles Alone or in Conjunction With a Sdkp-Conjugated Self-Assembling Peptide Improve a Rat Model of Myocardial Infarction, Biochemical and Biophysical Research Communications (2020)
13. The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases, Molecular Neurobiology (2019)
14. The Role of Exosomes Contents on Genetic and Epigenetic Alterations of Recipient Cancer Cells, Iranian Journal of Basic Medical Sciences (2016)
15. The Footprint of Exosomes in the Radiation-Induced Bystander Effects, Bioengineering (2022)
16. Exosomal Micrornas in Regulation of Tumor Cells Resistance to Apoptosis, Biochemistry and Biophysics Reports (2024)
17. Application of Stem Cell-Derived Exosomes in Anterior Segment Eye Diseases: A Comprehensive Update Review, Ocular Surface (2025)
18. Potential of Extracellular Vesicles in Neurodegenerative Diseases: Diagnostic and Therapeutic Indications, Journal of Molecular Neuroscience (2018)
19. Hypoxia Preconditioned Mesenchymal Stem Cell-Derived Exosomes Induce Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells Cd133+ by Stimulation of Notch Signaling Pathway, Biotechnology Progress (2022)
20. Communication Between Stromal and Hematopoietic Stem Cell by Exosomes in Normal and Malignant Bone Marrow Niche, Biomedicine and Pharmacotherapy (2020)
21. Induced Pluripotent Stem Cell-Derived Extracellular Vesicles: A Novel Approach for Cell-Free Regenerative Medicine, Journal of Cellular Physiology (2019)
22. Human Amniotic Membrane As a Delivery Vehicle for Stem Cell-Based Therapies, Life Sciences (2021)
23. Paper-Based Biosensors As Point-Of-Care Diagnostic Devices for the Detection of Cancers: A Review of Innovative Techniques and Clinical Applications, Frontiers in Oncology (2023)
24. Development and Clinical Application of Tumor-Derived Exosomes in Patients With Cancer, Current Stem Cell Research and Therapy (2022)
25. Mesenchymal Stem Cell Exosomes: A Two-Edged Sword in Cancer Therapy, International Journal of Nanomedicine (2019)
26. Extracellular Vesicles Derived From Human Umbilical Cord Perivascular Cells Improve Functional Recovery in Brain Ischemic Rat Via the Inhibition of Apoptosis Brain Ischemic Rat Via the Inhibition of Apoptosis, Iranian Biomedical Journal (2020)
27. Tumor-Derived Exosomal Micrornas and Proteins As Modulators of Macrophage Function, Journal of Cellular Physiology (2019)
28. Micrornas and Exosomes: Key Players in Hiv Pathogenesis, HIV Medicine (2020)
29. Influence of Plasma Circulating Exosomes Obtained From Obese Women on Tumorigenesis and Tamoxifen Resistance in Mcf-7 Cells, IUBMB Life (2020)
30. Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges, Molecular Neurobiology (2022)
31. Development and Application of Mesenchymal Stem Cell-Derived Exosomes in Cartilage Tissue Repair, Journal of Military Medicine (2022)
32. The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms, Frontiers in Pharmacology (2023)
33. Extracellular Vesicles As a Neprilysin Delivery System Memory Improvement in Alzheimer’S Disease, Iranian Journal of Pharmaceutical Research (2020)
34. Exosomes, Autophagy and Er Stress Pathways in Human Diseases: Cross-Regulation and Therapeutic Approaches, Biochimica et Biophysica Acta - Molecular Basis of Disease (2022)
35. Intrathecal Administration of the Extracellular Vesicles Derived From Human Wharton's Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes After Spinal Cord Injury in Rats, Neuroscience Research (2021)
36. Clonal Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve Mouse Model of Weight Drop-Induced Traumatic Brain Injury Through Reducing Cistauosis and Apoptosis, Experimental Neurology (2023)
37. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)
38. Cell and Cell-Derivative-Based Therapy for Liver Diseases: Current Approaches and Future Promises, Expert Review of Gastroenterology and Hepatology (2023)
39. Exosomal Micrornas Derived From Mesenchymal Stem Cells: Cell-To-Cell Messages, Cell Communication and Signaling (2020)
40. Designer Exosomes: A New Platform for Biotechnology Therapeutics, BioDrugs (2020)
41. Interaction Between Mesenchymal Stromal Cell-Derived Extracellular Vesicles and Immune Cells by Distinct Protein Content, Journal of Cellular Physiology (2019)
42. A Comprehensive Survey Into the Role of Exosomes in Pancreatic Cancer; From the Origin of Cancer to the Progress and Possibility of Diagnosis and Treatment, Pathology Research and Practice (2023)
43. Current Status of Stem Cell Therapy and Nanofibrous Scaffolds in Cardiovascular Tissue Engineering, Regenerative Engineering and Translational Medicine (2022)
44. Mirnas in Outer Membrane Vesicles of Gut Microbiota: Friend or Foe?, Microbial Pathogenesis (2020)
45. Extracellular Microvesicles: Biologic Properties, Biogenesis, and Applications in Leukemia, Molecular and Cellular Biochemistry (2024)
46. Potential Therapeutic Applications of Extracellular Vesicles in the Immunopathogenesis of Covid-19, Pathology Research and Practice (2023)
47. The Promising Approach of Mscs Therapy for Covid-19 Treatment, Cell and Tissue Banking (2023)
48. Extracellular Vesicles Derived From Human Embryonic Stem Cell-Mscs Ameliorate Cirrhosis in Thioacetamide-Induced Chronic Liver Injury, Journal of Cellular Physiology (2018)
49. Novel Cell-Based Therapies in Inflammatory Bowel Diseases: The Established Concept, Promising Results, Human Cell (2021)
50. Cartilage Tissue Engineering by Co-Transplantation of Chondrocyte Extracellular Vesicles and Mesenchymal Stem Cells, Entrapped in Chitosan-Hyaluronic Acid Hydrogel, Biomedical Materials (Bristol) (2021)