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Biocompatibility and Nanostructured Materials: Applications in Nanomedicine Publisher Pubmed



Adabi M1 ; Naghibzadeh M2 ; Adabi M1 ; Zarrinfard MA1 ; Esnaashari SS1 ; Seifalian AM4 ; Faridimajidi R1 ; Tanimowo Aiyelabegan H5 ; Ghanbari H1
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nanotechnology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Metallurgy and Materials Engineering, Faculty of Engineering, Roudehen Branch, Islamic Azad University, Roudehen, Tehran, Iran
  4. 4. Centre for Nanotechnology and Regenerative Medicine, University College London, London, United Kingdom
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017


Abstract

There has been huge interest in applications of nanomaterials in biomedical science, including diagnosis, drug delivery, and development of human organs. Number of these nanomaterials has been already studied in human or at pre-clinical trial. There is a growing concern on potential toxicity and adverse effects of nanomaterials on human health, including lack of standard method of assessment of toxicology of these materials. Our investigation indicated that the bare and small nanoparticle have higher toxicity than modified and bulk materials, respectively. In addition, spherical nanoparticles have less toxicity than rod nanoparticles due to immune response of body. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
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