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Global, Regional, and National Burden of Other Musculoskeletal Disorders, 1990–2020, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021 Publisher



Gill TK1 ; Mittinty MM2 ; March LM3, 5, 10 ; Steinmetz JD6 ; Culbreth GT6 ; Cross M3, 10 ; Kopec JA11, 12 ; Woolf AD10, 13 ; Haile LM6 ; Hagins H6 ; Ong KL6 ; Kopanskygiles DR10, 14, 15 ; Dreinhoefer KE16 ; Betteridge N10 Show All Authors
Authors
  1. Gill TK1
  2. Mittinty MM2
  3. March LM3, 5, 10
  4. Steinmetz JD6
  5. Culbreth GT6
  6. Cross M3, 10
  7. Kopec JA11, 12
  8. Woolf AD10, 13
  9. Haile LM6
  10. Hagins H6
  11. Ong KL6
  12. Kopanskygiles DR10, 14, 15
  13. Dreinhoefer KE16
  14. Betteridge N10
  15. Abbasian M17, 19
  16. Abbasifard M23, 24
  17. Abedi K25, 26
  18. Adesina MA28, 29
  19. Aithala JP31
  20. Akbarzadehkhiavi M32
  21. Thaher YA34, 35
  22. Alalwan TA36
  23. Alzahrani H37
  24. Amiri S1, 2, 38
  25. Antony B39
  26. Arabloo J40
  27. Aravkin AY6, 7, 8
  28. Arumugam A43, 46
  29. Aryal KK47
  30. Athari SS48
  31. Atreya A49
  32. Baghdadi S50
  33. Bardhan M13, 51, 52, 67, 68
  34. Barrero LH53
  35. Bearne LM54, 55
  36. Bekele AB56
  37. Bensenor IM58
  38. Bhardwaj P60, 61
  39. Bhatti R62
  40. Bijani A63
  41. Bordianu T6
  42. Bouaoud S64, 65
  43. Briggs AM10, 66
  44. Cheema HA67, 68
  45. Christensen SW69, 70
  46. Chukwu IS71
  47. Clarsen B72, 73
  48. Dai X6, 8
  49. De Luca K74
  50. Desye B75
  51. Dhimal M76
  52. Do TC77
  53. Fagbamigbe AF30, 78
  54. Forghani SF41, 42
  55. Ferreira N79
  56. Ganesan B80, 81
  57. Gebrehiwot M82
  58. Ghashghaee A83
  59. Graham SM84, 85
  60. Harlianto NI86, 87
  61. Hartvigsen J88, 89
  62. Hasaballah AI90
  63. Hasanian M91, 100
  64. Hassen MB6, 92
  65. Hay SI6, 8
  66. Heidari M93, 100
  67. Hsiao AK94
  68. Ilic IM95
  69. Jokar M96, 98
  70. Khajuria H99
  71. Khan MJ100
  72. Khanal P101
  73. Khateri S102
  74. Kiadaliri A103
  75. Kim MS104, 105
  76. Kisa A106, 107
  77. Kolahi AA20
  78. Krishan K108
  79. Krishnamoorthy V9, 109
  80. Landires I110, 111
  81. Larijani B112
  82. Le TTT116
  83. Lee YH117
  84. Lim SS6, 8
  85. Lo J6
  86. Madani SP118
  87. Malagonrojas JN119, 120
  88. Malik I121
  89. Marateb HR122, 123
  90. Mathew AJ124
  91. Meretoja TJ125, 126
  92. Mesregah MK127
  93. Mestrovic T6, 128
  94. Mirahmadi A21
  95. Misganaw A8, 92
  96. Mohaghegh S22
  97. Mokdad AH6, 8
  98. Momenzadeh K17
  99. Momtazmanesh S113, 114
  100. Monasta L129
  101. Moni MA130
  102. Moradi Y131
  103. Mostafavi E132, 133
  104. Muhammad JS44
  105. Murray CJL6, 8
  106. Muthu S134, 135
  107. Nargus S136, 139
  108. Nassereldine H6
  109. Neupane S140
  110. Niazi RK141
  111. Oh IH142
  112. Okatialiabad H143
  113. Oulhaj A144
  114. Pachecobarrios K18, 145
  115. Park S2, 146
  116. Patel J147, 148
  117. Pawar S149
  118. Pedersini P150
  119. Peres MF59, 151
  120. Petcu IR152
  121. Petermannrocha FE153, 154
  122. Poursadeqiyan M155
  123. Qattea I156
  124. Qureshi MF157
  125. Rafferty Q6
  126. Rahimidehgolan S115
  127. Rahman M158
  128. Ramasamy SK159
  129. Rashedi V160
  130. Redwan EMM161, 162
  131. Ribeiro DC163
  132. Roever L164
  133. Safary A33
  134. Sagoe D22, 165
  135. Sharifaskari FS45
  136. Sahebkar A137, 138
  137. Salehi S27
  138. Shafaat A123
  139. Shahabi S166
  140. Sharma S167, 168
  141. Shashamo BB57
  142. Shiri R169
  143. Singh A39
  144. Slater H66
  145. Smith AE6
  146. Sunuwar DR170, 171
  147. Tabish M172
  148. Tharwat S173
  149. Ullah I174
  150. Tahbaz SV97, 175
  151. Vasankari TJ176, 177
  152. Villafane JH150
  153. Vollset SE6, 8
  154. Wiangkham T178
  155. Yonemoto N179, 180
  156. You Y4, 181
  157. Zare I182
  158. Zheng P6, 8
  159. Vos T6, 8
  160. Brooks PM183

Source: The Lancet Rheumatology Published:2023


Abstract

Background: Musculoskeletal disorders include more than 150 different conditions affecting joints, muscles, bones, ligaments, tendons, and the spine. To capture all health loss from death and disability due to musculoskeletal disorders, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) includes a residual musculoskeletal category for conditions other than osteoarthritis, rheumatoid arthritis, gout, low back pain, and neck pain. This category is called other musculoskeletal disorders and includes, for example, systemic lupus erythematosus and spondylopathies. We provide updated estimates of the prevalence, mortality, and disability attributable to other musculoskeletal disorders and forecasted prevalence to 2050. Methods: Prevalence of other musculoskeletal disorders was estimated in 204 countries and territories from 1990 to 2020 using data from 68 sources across 23 countries from which subtraction of cases of rheumatoid arthritis, osteoarthritis, low back pain, neck pain, and gout from the total number of cases of musculoskeletal disorders was possible. Data were analysed with Bayesian meta-regression models to estimate prevalence by year, age, sex, and location. Years lived with disability (YLDs) were estimated from prevalence and disability weights. Mortality attributed to other musculoskeletal disorders was estimated using vital registration data. Prevalence was forecast to 2050 by regressing prevalence estimates from 1990 to 2020 with Socio-demographic Index as a predictor, then multiplying by population forecasts. Findings: Globally, 494 million (95% uncertainty interval 431–564) people had other musculoskeletal disorders in 2020, an increase of 123·4% (116·9–129·3) in total cases from 221 million (192–253) in 1990. Cases of other musculoskeletal disorders are projected to increase by 115% (107–124) from 2020 to 2050, to an estimated 1060 million (95% UI 964–1170) prevalent cases in 2050; most regions were projected to have at least a 50% increase in cases between 2020 and 2050. The global age-standardised prevalence of other musculoskeletal disorders was 47·4% (44·9–49·4) higher in females than in males and increased with age to a peak at 65–69 years in male and female sexes. In 2020, other musculoskeletal disorders was the sixth ranked cause of YLDs globally (42·7 million [29·4–60·0]) and was associated with 83 100 deaths (73 600–91 600). Interpretation: Other musculoskeletal disorders were responsible for a large number of global YLDs in 2020. Until individual conditions and risk factors are more explicitly quantified, policy responses to this burden remain a challenge. Temporal trends and geographical differences in estimates of non-fatal disease burden should not be overinterpreted as they are based on sparse, low-quality data. Funding: Bill & Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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