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A One-Pot, Three-Component, Solvent-Free Synthesis of Novel 6H-Chromeno[3’,4’:5,6]Pyrido[2,3-D]Pyrimidine-Triones Under Microwave Irradiation Publisher



Firoozpour L1 ; Yahyavi H1 ; Ejtemaei R2 ; Moghimi S1 ; Foroumadi A2, 3
Authors
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Authors Affiliations
  1. 1. Drug Design and Development Research Centre, Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neuroscience Research Centre, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Source: Journal of Chemical Research Published:2018


Abstract

A green and efficient method for preparing novel heterocyclic systems is established through the reaction of differently substituted benzaldehydes,barbituricacidand4-amino-2H-chromene-2-oneundersolvent-freeconditions.Thismethodaffords6H-chromeno[3’,4’:5,6] pyrido[2,3-d]pyrimidine-trione derivatives in high yields and short reaction times. © 2018 Science Reviews 2000 Ltd. All rights reserved.