Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Phytochemical Investigation and Cytotoxicity of Isolated Compounds From Marine Coral Sarcophyton Pisnilata Collected From the Persian Gulf on Hela Cancer Cells; [Sarcophyton Pisnilata بررسی فیتوشیمیایی و سمیت سلولی ترکیبات جدا شده از مرجان دریایی جمعآوری شده از خلیج فارس بر روی سلول سرطانی Hela]
Vajihe Akbari
Vajihe Akbari

Professor of Pharmaceutical Biotechnology

Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences

Pharmaceutical Sciences Research Center

Isfahan University of Medical Sciences

All Documents
1. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
2. Integrated Bioprocessing and Genetic Strategies to Enhance Soluble Expression of Anti-Her2 Immunotoxin in E. Coli, AMB Express (2024)
3. More Balance Toward Activating Receptors and Cytotoxic Activity of Nk Cells Ex Vivo Differentiated From Human Umbilical Cord Blood-Derived Cd34+ Stem Cells in Comparison With Peripheral Blood Nk Cells, Heliyon (2024)
4. Strong Capacity of Differentiated Pd-L1 Car-Modified Ucb-Cd34+ Cells and Pd-L1 Car-Modified Ucb-Cd34+-Derived Nk Cells in Killing Target Cells and Restoration of the Anti-Tumor Function of Pd-1-High Exhausted T Cells, Stem Cell Research and Therapy (2024)
5. Anti Her-2 Aptamer Functionalized Gold Nanoparticles of Dasatinib for Targeted Chemo-Radiotherapy in Breast Cancer Cells, Biomaterials Advances (2023)
6. Computational Design of Newly Engineered Darpins As Her2 Receptor Inhibitors for Breast Cancer Treatment, Research in Pharmaceutical Sciences (2023)
7. Construction and Periplasmic Expression of a Bispecific Tandem Scfv for Dual Targeting of Immune Checkpoints, Advanced Biomedical Research (2023)
8. Design and Construction of Scfv-Pe35kdel As a Novel Immunotoxin Against Human Epidermal Growth Factor Receptor 2 for Cancer Therapy, Biotechnology Letters (2023)
9. Development of Solubilization and Refolding Buffers, Methods in molecular biology (Clifton, N.J.) (2023)
10. Periplasmic Expression of a Novel Diabody for Co-Targeting Two Immune Checkpoints, Pd-1 and Ctla-4, Journal of Isfahan Medical School (2023)
11. Preparation and Characterization of Trimethyl Chitosan /Hyaluronic Acid Composite Encapsulated With Ll37 to Promote Wound Healing in an Animal Model, International Journal of Peptide Research and Therapeutics (2023)
12. Probiotic Lactobacillus and the Potential Risk of Spreading Antibiotic Resistance: A Systematic Review, Research in Pharmaceutical Sciences (2023)
13. An Injectable Thermosensitive Hydrogel/Nanomicelles Composite for Local Chemo-Immunotherapy in Mouse Model of Melanoma, Journal of Biomaterials Applications (2022)
14. Cancer Vaccines As a Targeted Immunotherapy Approach for Breast Cancer: An Update of Clinical Evidence, Expert Review of Vaccines (2022)
15. Co-Expression of Chaperones for Improvement of Soluble Expression and Purification of an Anti-Her2 Scfv in Escherichia Coli, Advanced Biomedical Research (2022)
16. Comparison of Four Methods of Colon Cancer Cell Lysates Preparation for Ex Vivo Maturation of Dendritic Cells, Research in Pharmaceutical Sciences (2022)
17. Drug Repositioning Approach to Target Viral and Host Cells in Terms of Covid-19 Treatment: A Review of in Vivo Experiments and Clinical Studies, Journal of Experimental and Clinical Medicine (Turkey) (2022)
18. Efficacy and Safety of Ibrutinib in Mantle Cell Lymphoma: A Systematic Review and Meta-Analysis, DARU, Journal of Pharmaceutical Sciences (2022)
19. Nisin Induces Apoptosis in Cervical Cancer Cells Via Reactive Oxygen Species Generation and Mitochondrial Membrane Potential Changes, Biochemistry and Cell Biology (2022)
20. Preparation and in Vitro Characterization of Histidine Trimethyl Chitosan Conjugated Nanocomplex Incorporated Into Injectable Thermosensitive Hydrogels for Localized Gene Delivery, Biotechnology and Applied Biochemistry (2022)
21. Preparation, Physicochemical, and Retinal Anti-Angiogenic Evaluation of Poloxamer Hydrogel Containing Dexamethasone/Avastin-Loaded Chitosan-N-Acetyl-L-Cysteine Nanoparticles, International Journal of Biological Macromolecules (2022)
22. Bioassay-Guided Fractionation and Antimicrobial Activities of Padina Australis Extracts, Jundishapur Journal of Natural Pharmaceutical Products (2021)
23. Development of N-Halamine Low-Melting Point Poly(Ethylene Terephthalate) Fibers Via Melt Spinning: Structural Characterization and Demonstration of Rechargeable Antibacterial Properties, Polymer-Plastics Technology and Materials (2021)
24. Dff40-Irgd, a Novel Chimeric Protein With Efficient Cytotoxic and Apoptotic Effects Against Triple-Negative Breast Cancer Cells, Biotechnology Letters (2021)
25. Inhibition of Aldehyde Dehydrogenase by Furazolidone Nanoemulsion to Decrease Cisplatin Resistance in Lung Cancer Cells, Therapeutic Delivery (2021)
26. Preparation and Characterization of Poly (Lactic-Co-Glycolic Acid) Nanofibers Containing Simvastatin Coated With Hyaluronic Acid for Using in Periodontal Tissue Engineering, Biotechnology Progress (2021)
27. Production and Evaluation of In-Vitro and In-Vivo Effects of P28-Il24, a Promising Anti-Breast Cancer Fusion Protein, International Journal of Peptide Research and Therapeutics (2021)
28. Risk of Neurodegenerative Disease Due to Tau Phosphorylation Changes and Arsenic Exposure Via Drinking Water, Toxicology Research (2021)
29. Risk of Neurodegenerative Disease Due to Tau Phosphorylation Changes and Arsenic Exposure Via Drinking Water, Toxicology Research (2021)
30. Survivin Promoter-Driven Dff40 Gene Expression Sensitizes Melanoma Cancer Cells to Chemotherapy, International Journal of Toxicology (2021)
31. Sustained-Release of Erythropoietin Using a Novel Injectable Thermosensitive Hydrogel: In Vitro Studies, Biological Activity, and Efficacy in Rats, Pharmaceutical Development and Technology (2021)
32. Bioassay-Guided Isolation of Glycolipids From the Seaweed Gracilaria Corticata, Research in Pharmaceutical Sciences (2020)
33. Comparison the Effects of Chitosan and Hyaluronic Acid-Based Thermally Sensitive Hydrogels Containing Rosuvastatin on Human Osteoblast-Like Mg-63 Cells, Research in Pharmaceutical Sciences (2020)
34. Evaluation of Soluble Expression of Recombinant Granulocyte Macrophage Stimulating Factor (Rgm-Csf) by Three Different E. Coli Strains, Research in Pharmaceutical Sciences (2020)
35. In Silico Design of Two Novel Fusion Proteins, P28-Il-24 and P28-M4, Targeted to Breast Cancer Cells, Research in Pharmaceutical Sciences (2020)
36. In Vitro Cytotoxic Activity of Verbascum Alceoides Against Cervix Carcinoma Cells, Journal of Reports in Pharmaceutical Sciences (2020)
37. New Insights Into Affinity Proteins for Her2-Targeted Therapy: Beyond Trastuzumab, Biochimica et Biophysica Acta - Reviews on Cancer (2020)
38. New Insights Into Affinity Proteins for Her2-Targeted Therapy: Beyond Trastuzumab, Biochimica et Biophysica Acta - Reviews on Cancer (2020)
39. Optimization of Buffer Additives for Efficient Recovery of Hgm-Csf From Inclusion Bodies Using Response Surface Methodology, Iranian Journal of Pharmaceutical Research (2020)
40. Rational Design of a New Mutant of Tobacco Etch Virus Protease in Order to Increase the in Vitro Solubility, Research in Pharmaceutical Sciences (2020)
41. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
42. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
43. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
44. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
45. Cloning, Optimization of Periplasmic Expression and Purification of Recombinant Granulocyte Macrophage-Stimulating Factor in Escherichia Coli Bl21 (De3), Advanced Biomedical Research (2019)
46. High-Yield Production of Granulocyte-Macrophage Colony-Stimulating Factor in E. Coli Bl21 (De3) by an Auto-Induction Strategy, Iranian Journal of Pharmaceutical Research (2019)
47. Improvement of Soluble Expression of Gm-Csf in the Cytoplasm of Escherichia Coli Using Chemical and Molecular Chaperones, Protein Expression and Purification (2019)
48. Improvement of Soluble Production of Reteplase in Escherichia Coli by Optimization of Chemical Chaperones in Lysis Buffer, Advanced Biomedical Research (2019)
49. Incorporation of Rosuvastatin-Loaded Chitosan/Chondroitin Sulfate Nanoparticles Into a Thermosensitive Hydrogel for Bone Tissue Engineering: Preparation, Characterization, and Cellular Behavior, Pharmaceutical Development and Technology (2019)
50. Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line, Iranian Journal of Pharmaceutical Research (2019)
51. Nanocrystalline Cellulose-Hyaluronic Acid Composite Enriched With Gm-Csf Loaded Chitosan Nanoparticles for Enhanced Wound Healing, Biomedical Materials (Bristol) (2019)
52. Optimization of Fermentation Conditions for Reteplase Expression by Escherichia Coli Using Response Surface Methodology, Avicenna Journal of Medical Biotechnology (2019)
53. Thermosensitive Hydrogel Containing Sertaconazole Loaded Nanostructured Lipid Carriers for Potential Treatment of Fungal Keratitis, Pharmaceutical Development and Technology (2019)
54. A Mucoadhesive Thermosensitive Hydrogel Containing Erythropoietin As a Potential Treatment in Oral Mucositis: In Vitro and in Vivo Studies, Drug Delivery and Translational Research (2018)
55. Anti-Tuberculosis and Cytotoxic Evaluation of the Seaweed Sargassum Boveanum, Research in Pharmaceutical Sciences (2018)
56. Effect of Freeze Drying on Stability, Thermo-Responsive Characteristics, and in Vivo Wound Healing of Erythropoietin-Loaded Trimethyl Chitosan/Glycerophosphate Hydrogel, Research in Pharmaceutical Sciences (2018)
57. Improvement of Solubility and Refolding of an Anti-Human Epidermal Growth Factor Receptor 2 Single-Chain Antibody Fragment Inclusion Bodies, Research in Pharmaceutical Sciences (2018)
58. Improvement of Solubility and Refolding of an Anti-Human Epidermal Growth Factor Receptor 2 Single-Chain Antibody Fragment Inclusion Bodies, Research in Pharmaceutical Sciences (2018)
59. In Vitro Cytotoxic Activity of a Lactococcus Lactis Antimicrobial Peptide Against Breast Cancer Cells, Iranian Journal of Biotechnology (2018)
60. Preparation and Characterization of an Injectable Thermosensitive Hydrogel for Simultaneous Delivery of Paclitaxel and Doxorubicin, Research in Pharmaceutical Sciences (2018)
61. Preparation of an Injectable Doxorubicin Surface Modified Cellulose Nanofiber Gel and Evaluation of Its Anti-Tumor and Anti-Metastasis Activity in Melanoma, Biotechnology Progress (2018)
62. Probiotic Supplementation for Management of Cardiovascular Risk Factors in Adults With Type Ii Diabetes: A Systematic Review and Meta-Analysis, Clinical Nutrition (2018)
63. Preparation and Characterization of Metformin Surface Modified Cellulose Nanofiber Gel and Evaluation of Its Anti-Metastatic Potentials, Carbohydrate Polymers (2017)
64. Clinical Applications of Cell Encapsulation Technology in Cell and Drug Delivery, Journal of Isfahan Medical School (2016)
65. Effects of Probiotic Supplementation in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis, Nutrition Reviews (2016)
66. Efficacy and Safety of Oral Insulin Compared to Subcutaneous Insulin: A Systematic Review and Meta-Analysis, Journal of Endocrinological Investigation (2016)
67. Improved Biological Activity of a Single Chain Antibody Fragment Against Human Epidermal Growth Factor Receptor 2 (Her2) Expressed in the Periplasm of Escherichia Coli, Protein Expression and Purification (2015)
68. Optimization of a Single-Chain Antibody Fragment Overexpression in Escherichia Coli Using Response Surface Methodology, Research in Pharmaceutical Sciences (2015)
69. Release Studies on Ciprofloxacin Loaded Non-Ionic Surfactant Vesicles, Avicenna Journal of Medical Biotechnology (2015)
70. Efficacy and Safety of Saccharomyces Boulardii for Acute Diarrhea, Pediatrics (2014)
71. Functional Expression of a Single-Chain Antibody Fragment Against Human Epidermal Growth Factor Receptor 2 (Her2) in Escherichia Coli, Journal of Industrial Microbiology and Biotechnology (2014)
72. Ciprofloxacin Nano-Niosomes for Targeting Intracellular Infections: An in Vitro Evaluation, Journal of Nanoparticle Research (2013)
73. Comparison of Five Methods for Extraction of Genomic Dna From a Marine Archaea, Pyrococcus Furiosus, Pakistan Journal of Medical Sciences (2013)
74. In Vitro Anti-Bacterial and Anti-Adherence Effects of Lactobacillus Delbrueckii Subsp Bulgaricus on Escherichia Coli, Research in Pharmaceutical Sciences (2013)
75. Optimization of the Expression of Genes Encoding Poly (3-Hydroxyalkanoate) Synthase From Pseudomonas Aeruginosa Ptcc 1310 in Escherichia Coli, Avicenna Journal of Medical Biotechnology (2012)
76. Comparison of Epothilone and Taxol Binding in Yeast Tubulin Using Molecular Modeling, Avicenna Journal of Medical Biotechnology (2011)