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Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Non-Coding Rnas As Potential Therapeutic Targets for Receptor Tyrosine Kinase Signaling in Solid Tumors: Current Status and Future Directions

Reza Meshkani

Reza Meshkani

Professor of Clinical Biochemistry

Department Biochemistry

School of Medicine

Tehran University of Medical Sciences

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1. Optimized Effects of Fisetin and Hydroxychloroquine on Er Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice, Journal of Diabetes Research (2025)

2. Therapeutic Potential of Fisetin in Hepatic Steatosis: Insights Into Autophagy Pathway Regulation and Endoplasmic Reticulum Stress Alleviation in High-Fat Diet-Fed Mice, PLoS ONE (2025)

3. Unlocking the Therapeutic Potential of Autophagy Modulation by Natural Products in Tackling Non-Alcoholic Fatty Liver Disease, Phytotherapy Research (2025)

4. Combination Therapy of Metformin and Morin Attenuates Insulin Resistance, Inflammation, and Oxidative Stress in Skeletal Muscle of High-Fat Diet-Fed Mice, Phytotherapy Research (2024)

5. Resveratrol Relieves Hfd-Induced Insulin Resistance in Skeletal Muscle Tissue Through Antioxidant Capacity Enhancement and the Nrf2-Keap1 Signaling Pathway, Molecular Biology Reports (2024)

6. The Protective Effects of Fisetin in Metabolic Disorders: A Focus on Oxidative Stress and Associated Events, Journal of Diabetes and Metabolic Disorders (2024)

7. Amelioration of Obesity-Induced White Adipose Tissue Inflammation by Bacillus Coagulans T4 in a High-Fat Diet-Induced Obese Murine Model, Life Sciences (2023)

8. Combination Therapy of Metformin and P-Coumaric Acid Mitigates Metabolic Dysfunction Associated With Obesity and Nonalcoholic Fatty Liver Disease in High-Fat Diet Obese C57bl/6 Mice, Journal of Nutritional Biochemistry (2023)

9. Crosstalk Between Alzheimer’S Disease and Diabetes: A Focus on Anti-Diabetic Drugs, Metabolic Brain Disease (2023)

10. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)

11. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)

12. Folic Acid Ameliorates Palmitate-Induced Inflammation Through Decreasing Homocysteine and Inhibiting Nf-Κb Pathway in Hepg2 Cells, Archives of Physiology and Biochemistry (2023)

13. Metformin-Chlorogenic Acid Combination Reduces Skeletal Muscle Inflammation in C57bl/6 Mice on High-Fat Diets, Molecular Biology Reports (2023)

14. Multiple Novel Functions of Circular Rnas in Diabetes Mellitus, Archives of Physiology and Biochemistry (2023)

15. Principal Component Analysis of Adipose Tissue Gene Expression of Lipogenic and Adipogenic Factors in Obesity, BMC Endocrine Disorders (2023)

16. Resveratrol As a Potential Protective Compound Against Skeletal Muscle Insulin Resistance, Heliyon (2023)

17. The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice, Life Sciences (2023)

18. Chlorogenic Acid Improves Anti-Lipogenic Activity of Metformin by Positive Regulating of Ampk Signaling in Hepg2 Cells, Cell Biochemistry and Biophysics (2022)

19. Metformin Reduces Lipid Accumulation in Hepg2 Cells Via Downregulation of Mir-33B, Archives of Physiology and Biochemistry (2022)

20. Polyphenols: Potential Anti-Inflammatory Agents for Treatment of Metabolic Disorders, Phytotherapy Research (2022)

21. The Role of Protein Tyrosine Phosphatase 1B (Ptp1b) in the Pathogenesis of Type 2 Diabetes Mellitus and Its Complications, Journal of Physiology and Biochemistry (2022)

22. Anti-Inflammatory Effects of Plasma Circulating Exosomes Obtained From Normal-Weight and Obese Subjects on Hepatocytes, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)

23. Combination of Metformin and Chlorogenic Acid Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet Fed Mice, IUBMB Life (2021)

24. Combination of Metformin and Genistein Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Fed Mice, Journal of Nutritional Biochemistry (2021)

25. Competing Endogenous Rnas (Cernas): Novel Network in Neurological Disorders, Current Medicinal Chemistry (2021)

26. Evaluating the Effect of a Mixture of Two Main Conjugated Linoleic Acid Isomers on Hepatic Steatosis in Hepg2 Cellular Model, Molecular Biology Reports (2021)

27. Metformin in Combination With Genistein Ameliorates Skeletal Muscle Inflammation in High-Fat Diet Fed C57bl/6 Mice, Cytokine (2021)

28. The Relationship Between Nrf2/Keap1 System and Endoplasmic Reticulum Stress and Inflammatory Markers in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Subjects, Clinical Diabetology (2021)

29. Acetylation and Insulin Resistance: A Focus on Metabolic and Mitogenic Cascades of Insulin Signaling, Critical Reviews in Clinical Laboratory Sciences (2020)

30. Adipose Tissue Mrna Expression of Hdac1, Hdac3 and Hdac9 in Obese Women in Relation to Obesity Indices and Insulin Resistance, Molecular Biology Reports (2020)

31. Close Relationship Between Diabetes and Cancer, Iranian Journal of Public Health (2020)

32. Construction and Functional Characterization of a Fully Human Anti-Mesothelin Chimeric Antigen Receptor (Car) Expressing T Cell, Iranian Journal of Allergy# Asthma and Immunology (2020)

33. Effect of Circulating Exosomes Derived From Normal-Weight and Obese Women on Gluconeogenesis, Glycogenesis, Lipogenesis and Secretion of Fgf21 and Fetuin a in Hepg2 Cells, Diabetology and Metabolic Syndrome (2020)

34. Fatty Acid Synthase and Acetyl-Coa Carboxylase Dysfunction in Visceral Adipose Tissue, Journal of Payavard Salamat (2020)

35. Genetic and Pharmacological Targeting of A2a Receptor Improves Function of Anti-Mesothelin Car T Cells, Journal of Experimental and Clinical Cancer Research (2020)

36. Inhibiting Mir-27A and Mir-142-5P Attenuate Nonalcoholic Fatty Liver Disease by Regulating Nrf2 Signaling Pathway, IUBMB Life (2020)

37. Interplay Between Oxidative Stress and Autophagy Function and Its Role in Inflammatory Cytokine Expression Induced by Palmitate in Skeletal Muscle Cells, Cytokine (2020)

38. Microrna-141 Is Associated With Hepatic Steatosis by Downregulating the Sirtuin1/Amp-Activated Protein Kinase Pathway in Hepatocytes, Journal of Cellular Physiology (2020)

39. Nicotinamide Phosphoribosyltransferase Knockdown Leads to Lipid Accumulation in Hepg2 Cells Through the Sirt1-Ampk Pathway, Cell Journal (2020)

40. Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway, International Journal of Biochemistry and Cell Biology (2020)

41. Resveratrol Alleviates Obesity-Induced Skeletal Muscle Inflammation Via Decreasing M1 Macrophage Polarization and Increasing the Regulatory T Cell Population, Scientific Reports (2020)

42. Resveratrol Reduces Lipid Accumulation Through Upregulating the Expression of Micrornas Regulating Fatty Acid Bet Oxidation in Liver Cells: Evidence From In-Vivo and In-Vitro Studies, Iranian Journal of Pharmaceutical Research (2020)

43. The Effect of Resveratrol Supplementation on C-Reactive Protein (Crp) in Type 2 Diabetic Patients: Results From a Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)

44. The Interaction Between Gene Profile and Obesity in Type 2 Diabetes: A Review, Obesity Medicine (2020)

45. Therapeutic Effect of Resveratrol Supplementation on Oxidative Stress: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Postgraduate Medical Journal (2020)

46. Association of Carotid Intima Media Thickness With Atherogenic Index of Plasma, Apo B/Apo A-I Ratio and Paraoxonase Activity in Patients With Non-Alcoholic Fatty Liver Disease, Archives of Physiology and Biochemistry (2019)

47. Hesperetin Is a Potent Bioactivator That Activates Sirt1-Ampk Signaling Pathway in Hepg2 Cells, Journal of Physiology and Biochemistry (2019)

48. In-Vitro Synergistic Effect of Metformin and Berberine on High Glucose-Induced Lipogenesis, Iranian Journal of Pharmaceutical Research (2019)

49. Microrna-494 Induces Breast Cancer Cell Apoptosis and Reduces Cell Viability by Inhibition of Nicotinamide Phosphoribosyltransferase Expression and Activity, EXCLI Journal (2019)

50. Signaling Crosstalk of Fhit, P53, and P38 in Etoposide-Induced Apoptosis in Mcf-7 Cells, Journal of Cellular Biochemistry (2019)

51. The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer, International Journal of Endocrinology and Metabolism (2019)

52. The Role of Micrornas in the Regulation of Insulin Signaling Pathway With Respect to Metabolic and Mitogenic Cascades: A Review, Journal of Cellular Biochemistry (2019)

53. Aerobic Endurance Training Improves Nonalcoholic Fatty Liver Disease (Nafld) Features Via Mir-33 Dependent Autophagy Induction in High Fat Diet Fed Mice, Obesity Research and Clinical Practice (2018)

54. Correction To: The Effects of Resveratrol on Markers of Oxidative Stress in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial (Acta Diabetologica, (2018), 55, 4, (341-353), 10.1007/S00592-017-1098-3), Acta Diabetologica (2018)

55. Curcumin Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Regulating Jnk/Nf-Kb Pathway and Ros Production, Inflammopharmacology (2018)

56. Decreased Serum Level of Mir-155 Is Associated With Obesity and Its Related Metabolic Traits, Clinical Laboratory (2018)

57. Decreased Serum Microrna-21 Level Is Associated With Obesity in Healthy and Type 2 Diabetic Subjects, Archives of Physiology and Biochemistry (2018)

58. Effect of Resveratrol Supplementation on Inflammatory Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Therapeutics (2018)

59. Evidence for the Link Between Defective Autophagy and Inflammation in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Patients, Journal of Physiology and Biochemistry (2018)

60. Genetic Variants in Long Noncoding Rna H19 and Meg3 Confer Risk of Type 2 Diabetes in an Iranian Population, Gene (2018)

61. High Glucose Induces Inflammatory Responses in Hepg2 Cells Via the Oxidative Stress-Mediated Activation of Nf-Κb, and Mapk Pathways in Hepg2 Cells, Archives of Physiology and Biochemistry (2018)

62. Impaired Hdl Cholesterol Efflux Capacity in Patients With Non-Alcoholic Fatty Liver Disease Is Associated With Subclinical Atherosclerosis, Scientific Reports (2018)

63. Investigating the Effect of Visfatin on Erα Phosphorylation (Ser118 and Ser167) and Ere-Dependent Transcriptional Activity, EXCLI Journal (2018)

64. Mcu-Knockdown Attenuates High Glucose-Induced Inflammation Through Regulating Mapks/Nf-Κb Pathways and Ros Production in Hepg2 Cells, PLoS ONE (2018)

65. Palmitate-Induced Impairment of Autophagy Turnover Leads to Increased Apoptosis and Inflammation in Peripheral Blood Mononuclear Cells, Immunobiology (2018)

66. Reply to Letter to the Editor “The Effects of Resveratrol on Markers of Oxidative Stress in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial”, Acta Diabetologica (2018)

67. Resveratrol Supplementation Decreases Blood Glucose Without Changing the Circulating Cd14 + Cd16 + Monocytes and Inflammatory Cytokines in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Study, Nutrition Research (2018)

68. The Effects of Resveratrol on Markers of Oxidative Stress in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Acta Diabetologica (2018)

69. The Rs2910164 Variant Is Associated With Reduced Mir-146A Expression But Not Cytokine Levels in Patients With Type 2 Diabetes, Journal of Endocrinological Investigation (2018)

70. Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: A Case-Control Study, Journal of Medical Biochemistry (2017)

71. Association of Mir-146A Expression and Type 2 Diabetes Mellitus: A Meta-Analysis, International Journal of Molecular and Cellular Medicine (2017)

72. Association of Warfarin Therapy With Apoe and Vkorc1 Genes Polymorphism in Iranian Population, Iranian Journal of Pharmaceutical Research (2017)

73. Iran Diabetes Research Roadmap (Idrr) Study; Trends of Basic Sciences Publication: A Review Article, Iranian Journal of Public Health (2017)

74. Prevalence of Metabolic Syndrome Among Iranian Population: A Systematic Review and Meta-Analysis, Iranian Journal of Public Health (2017)

75. Protein Tyrosine Phosphatase 1B (Ptp1b) Is Required for Cardiac Lineage Differentiation of Mouse Embryonic Stem Cells, Molecular and Cellular Biochemistry (2017)

76. Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and Jnk/Nf-Κb Pathway in a Sirt1-Independent Mechanism, Journal of Cellular Biochemistry (2017)

77. Synergistic Effects of Ad-Libitum Low-Dose Fructose Drinking and Low-Dose Streptozotocin Treatment in Wistar Rats: A Mild Model of Type 2 Diabetes, Acta Medica Iranica (2017)

78. The Circulating Levels of Complement-Clq/Tnf-Related Protein 13 (Ctrp13) in Patients With Type 2 Diabetes and Its Association With Insulin Resistance, Clinical Laboratory (2017)

79. A Bioinformatics Approach to Prioritize Single Nucleotide Polymorphisms in Tlrs Signaling Pathway Genes, International Journal of Molecular and Cellular Medicine (2016)

80. A Simple, Rapid, and Efficient Method for Isolating Mesenchymal Stem Cells From the Entire Umbilical Cord, Cell Transplantation (2016)

81. A Simple, Rapid, and Efficient Method for Isolating Mesenchymal Stem Cells From the Entire Umbilical Cord, Cell transplantation (2016)

82. Association Between Leptin G2548a and Leptin Receptor Q223r Polymorphisms With Type 2 Diabetes in an Iranian Population, Clinical Laboratory (2016)

83. Association of Mir-146A Rs2910164 and Mir-149 Rs2292832 Variants With Susceptibility to Type 2 Diabetes, Clinical Laboratory (2016)

84. Decreased Expression of Microrna-21 Is Associated With Increased Cytokine Production in Peripheral Blood Mononuclear Cells (Pbmcs) of Obese Type 2 Diabetic and Non-Diabetic Subjects, Molecular and Cellular Biochemistry (2016)

85. Effects of Resveratrol on Crosstalk Between Canonical B-Catenin/Wnt and Foxo Pathways in Coronary Artery Disease Patients With Metabolic Syndrome: A Case Control Study, Iranian Journal of Pharmaceutical Research (2016)

86. Molecular and Cellular Mechanisms Linking Inflammation to Insulin Resistance and Β-Cell Dysfunction, Translational Research (2016)

87. Tissue Resident Macrophages: Key Players in the Pathogenesis of Type 2 Diabetes and Its Complications, Clinica Chimica Acta (2016)

88. Downregulated Microrna-155 Expression in Peripheral Blood Mononuclear Cells of Type 2 Diabetic Patients Is Not Correlated With Increased Inflammatory Cytokine Production, Cytokine (2015)

89. Inhibition of Sh2-Domain-Containing Inositol 5-Phosphatase (Ship2) Ameliorates Palmitate Induced-Apoptosis Through Regulating Akt/Foxo1 Pathway and Ros Production in Hepg2 Cells, Biochemical and Biophysical Research Communications (2015)

90. Sh2 Domain-Containing Inositol 5-Phosphatase (Ship2) Inhibition Ameliorates High Glucose-Induced De-Novo Lipogenesis and Vldl Production Through Regulating Ampk/Mtor/Srebp1 Pathway and Ros Production in Hepg2 Cells, Free Radical Biology and Medicine (2015)

91. Sh2 Domain-Containing Inositol 5-Phosphatase (Ship2) Regulates De-Novo Lipogenesis and Secretion of Apob100 Containing Lipoproteins in Hepg2 Cells, Biochemical and Biophysical Research Communications (2015)