Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Obstacles in the Development of Therapeutic Cancer Vaccines
Jamshid Hadjati
Jamshid Hadjati

Professor of Medical Immunology

Department Immunology

School of Medicine

Autoimmune Bullous Diseases Research Center

Tehran University of Medical Sciences

All Documents
1. Anti-Ctla-4 Nanobody As a Promising Approach in Cancer Immunotherapy, Cell death & disease (2024)
2. Px-478, an Hif-1Α Inhibitor, Impairs Mesocar T Cell Antitumor Function in Cervical Cancer, Frontiers in Oncology (2024)
3. Crosstalk Between Autophagy and Metabolic Regulation of (Car) T Cells: Therapeutic Implications, Frontiers in Immunology (2023)
4. Microrna-124 Enhances T Cells Functions by Manipulating the Lactic Acid Metabolism of Tumor Cells, Iranian Journal of Allergy# Asthma and Immunology (2023)
5. Pge2-Ep2/Ep4 Signaling Elicits Mesocar T Cell Immunosuppression in Pancreatic Cancer, Frontiers in Immunology (2023)
6. The Inhibitory Receptors Pd1, Tim3, and A2ar Are Highly Expressed During Mesocar T Cell Manufacturing in Advanced Human Epithelial Ovarian Cancer, Cancer Cell International (2023)
7. A Novel Formulation of Cyclosporine A/Phosphatidylserine-Containing Liposome Using Remote Loading Method: Potential Product for Immunosuppressive Effects, Journal of Drug Delivery Science and Technology (2022)
8. Agent-Based Modeling of Tumor and Immune System Interactions in Combinational Therapy With Low-Dose 5-Fluorouracil and Dendritic Cell Vaccine in Melanoma B16f10, Iranian Journal of Allergy# Asthma and Immunology (2022)
9. Identification of the Optimal Pattern of the Injection and Dosage of Dc Immunotherapy Using the Mathematical Models Based on Ordinary Differential Equations, Iranian Journal of Immunology (2022)
10. Restricting Tumor Lactic Acid Metabolism Using Dichloroacetate Improves T Cell Functions, BMC Cancer (2022)
11. Soluble and Immobilized Anti-Cd3/28 Distinctively Expand and Differentiate Primary Human T Cells: An Implication for Adoptive T Cell Therapy, Iranian Journal of Allergy# Asthma and Immunology (2022)
12. Targeting Hypoxia and Hypoxia-Inducible Factor-1 in the Tumor Microenvironment for Optimal Cancer Immunotherapy, Journal of Cellular Physiology (2022)
13. A Facile Way to Synthesize a Photocrosslinkable Methacrylated Chitosan Hydrogel for Biomedical Applications, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
14. A Metabolic Switch to Memory Car T Cells: Implications for Cancer Treatment, Cancer Letters (2021)
15. Chimeric Antigen Receptor (Car) T Cell Therapy for Metastatic Melanoma: Challenges and Road Ahead, Cells (2021)
16. Crispr/Cas9-Mediated Tgfβrii Disruption Enhances Anti-Tumor Efficacy of Human Chimeric Antigen Receptor T Cells in Vitro, Journal of Translational Medicine (2021)
17. Dendritic Cells Loaded With Exosomes Derived From Cancer Stem Cell-Enriched Spheroids As a Potential Immunotherapeutic Option, Journal of Cellular and Molecular Medicine (2021)
18. Epigenetic Strategies to Boost Car T Cell Therapy, Molecular Therapy (2021)
19. Extracting Mutual Interaction Rules Using Fuzzy Structured Agent-Based Model of Tumor-Immune System Interactions, Journal of Biomedical Physics and Engineering (2021)
20. Genetic Modification of Cytokine Signaling to Enhance Efficacy of Car T Cell Therapy in Solid Tumors, Frontiers in Immunology (2021)
21. Prediction of Anti-Cd25 and 5-Fu Treatments Efficacy for Pancreatic Cancer Using a Mathematical Model, BMC Cancer (2021)
22. Targeted Knockdown of Tim3 by Short Hairpin Rnas Improves the Function of Anti-Mesothelin Car T Cells, Molecular Immunology (2021)
23. A New Tumor-Immunotherapy Regimen Based on Impulsive Control Strategy, Biomedical Signal Processing and Control (2020)
24. Construction and Functional Characterization of a Fully Human Anti-Mesothelin Chimeric Antigen Receptor (Car) Expressing T Cell, Iranian Journal of Allergy# Asthma and Immunology (2020)
25. Engineered Jurkat Cells for Targeting Prostate-Specific Membrane Antigen on Prostate Cancer Cells by Nanobody-Based Chimeric Antigen Receptor, Iranian Biomedical Journal (2020)
26. Genetic and Pharmacological Targeting of A2a Receptor Improves Function of Anti-Mesothelin Car T Cells, Journal of Experimental and Clinical Cancer Research (2020)
27. Highly Efficient Generation of Transgenically Augmented Car Nk Cells Overexpressing Cxcr4, Frontiers in Immunology (2020)
28. Optimized Dose of Dendritic Cell-Based Vaccination in Experimental Model of Tumor Using Artificial Neural Network, Iranian Journal of Allergy# Asthma and Immunology (2020)
29. Pharmacological Targeting of Immune Checkpoint A2ar Improves Function of Anti-Cd19 Car T Cells in Vitro, Immunology Letters (2020)
30. Prolonged Persistence of Chimeric Antigen Receptor (Car) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward, Frontiers in Immunology (2020)
31. The Upregulation of Hsa-Mir-181B-1 and Downregulation of Its Target Cyld in the Late-Stage of Tumor Progression of Breast Cancer, Indian Journal of Clinical Biochemistry (2020)
32. The Upregulation of Hsa-Mir-181B-1 and Downregulation of Its Target Cyld in the Late-Stage of Tumor Progression of Breast Cancer, Indian Journal of Clinical Biochemistry (2020)
33. Adenosine Blockage in Tumor Microenvironment and Improvement of Cancer Immunotherapy, Immune Network (2019)
34. An Agent-Based Model for Investigating the Effect of Myeloid-Derived Suppressor Cells and Its Depletion on Tumor Immune Surveillance, Journal of Medical Signals and Sensors (2019)
35. Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target, Human Vaccines and Immunotherapeutics (2019)
36. Construction and Functional Characterization of a Fully Human Anti-Cd19 Chimeric Antigen Receptor (Hucar)-Expressing Primary Human T Cells, Journal of Cellular Physiology (2019)
37. Construction of a Chimeric Antigen Receptor Bearing a Nanobody Against Prostate a Specific Membrane Antigen in Prostate Cancer, Journal of Cellular Biochemistry (2019)
38. Effects of Dendritic Cell Vaccine Activated With Components of Lieshmania Major on Tumor Specific Response, Iranian Journal of Immunology (2019)
39. Predictive and Therapeutic Biomarkers in Chimeric Antigen Receptor T-Cell Therapy: A Clinical Perspective, Journal of Cellular Physiology (2019)
40. Sodium Butyrate As a Histone Deacetylase Inhibitor Affects Toll-Like Receptor 4 Expression in Colorectal Cancer Cell Lines, Immunological Investigations (2019)
41. A Structural Methodology for Modeling Immune-Tumor Interactions Including Pro- and Anti-Tumor Factors for Clinical Applications, Mathematical Biosciences (2018)
42. Anti-Angiogenic Effects of Cd73-Specific Sirna-Loaded Nanoparticles in Breast Cancer-Bearing Mice, Journal of Cellular Physiology (2018)
43. Characterization of Decellularized Ovine Small Intestine Submucosal Layer As Extracellular Matrix-Based Scaffold for Tissue Engineering, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2018)
44. Critical-Sized Full-Thickness Skin Defect Regeneration Using Ovine Small Intestinal Submucosa With or Without Mesenchymal Stem Cells in Rat Model, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2018)
45. Gene-Knocked Out Chimeric Antigen Receptor (Car) T Cells: Tuning up for the Next Generation Cancer Immunotherapy, Cancer Letters (2018)
46. Gene-Knocked Out Chimeric Antigen Receptor (Car) T Cells: Tuning up for the Next Generation Cancer Immunotherapy, Cancer Letters (2018)
47. Investigation of Antitumor Effects of Lactobacillus Crispatus in Experimental Model of Breast Cancer in Balb/C Mice, Immunotherapy (2018)
48. Mathematical Model of Cancer Immunotherapy by Dendritic Cells Combined With Tumor Hypoxia Treatment, 2018 25th Iranian Conference on Biomedical Engineering and 2018 3rd International Iranian Conference on Biomedical Engineering# ICBME 2018 (2018)
49. Mathematical Modeling of In-Vivo Tumor-Immune Interactions for the Cancer Immunotherapy Using Matured Dendritic Cells, Journal of Biological Systems (2018)
50. Modeling the Strategies of Interactions Between Melanoma Tumor and Cd8+ Immune Cells Using Game Theory, 2018 25th Iranian Conference on Biomedical Engineering and 2018 3rd International Iranian Conference on Biomedical Engineering# ICBME 2018 (2018)
51. Myeloid-Derived Suppressor Cells Elimination by 5-Fluorouracil Increased Dendritic Cell-Based Vaccine Function and Improved Immunity in Tumor Mice, Iranian Journal of Allergy# Asthma and Immunology (2018)
52. Myeloid-Derived Suppressor Cells Elimination by 5-Fluorouracil Increased Dendritic Cell-Based Vaccine Function and Improved Immunity in Tumor Mice, Iranian Journal of Allergy, Asthma and Immunology (2018)
53. Prophylactic Dna Vaccine Targeting Foxp3+ Regulatory T Cells Depletes Myeloid-Derived Suppressor Cells and Improves Anti-Melanoma Immune Responses in a Murine Model, Cancer Immunology, Immunotherapy (2018)
54. Prophylactic Dna Vaccine Targeting Foxp3+ Regulatory T Cells Depletes Myeloid-Derived Suppressor Cells and Improves Anti-Melanoma Immune Responses in a Murine Model, Cancer Immunology# Immunotherapy (2018)
55. Tolerance Induction by Surface Immobilization of Jagged-1 for Immunoprotection of Pancreatic Islets, Biomaterials (2018)
56. An Extended Mathematical Model of Tumor Growth and Its Interaction With the Immune System, to Be Used for Developing an Optimized Immunotherapy Treatment Protocol, Mathematical Biosciences (2017)
57. Cd73 Specific Sirna Loaded Chitosan Lactate Nanoparticles Potentiate the Antitumor Effect of a Dendritic Cell Vaccine in 4T1 Breast Cancer Bearing Mice, Journal of Controlled Release (2017)
58. Development of a Time and Cost Benefit Antibody Binding Test-Based Method for Determination of Rabies Vaccine Potency, Viral Immunology (2017)
59. Effect of Microrna-21 Transfection on In-Vitro Differentiation of Human Naive Cd4+ T Cells to Regulatory T Cells, Iranian Journal of Allergy# Asthma and Immunology (2017)
60. Increased Efficacy of a Dendritic Cell–Based Therapeutic Cancer Vaccine With Adenosine Receptor Antagonist and Cd73 Inhibitor, Tumor Biology (2017)
61. Investigation of Properties of Chemically Cross-Linked Silk Nanofibrous Mat As a Nerve Guide, Materials Technology (2017)
62. Stable Silencing of Igf1r Using Lentiviral-Mediated Shrna in Hek293t Cells, Cellular and Molecular Biology (2017)
63. Study of the Tumor Microenvironment During Breast Cancer Progression, Cancer Cell International (2017)
64. Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents, Current Medicinal Chemistry (2016)
65. Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents, Current Medicinal Chemistry (2016)
66. Commentary: Il-12-Secreting Tumor-Targeted Chimeric Antigen Receptor T Cells: An Unaddressed Concern on Koneru Et Al. (2015), OncoImmunology (2016)
67. Construction and Production of Foxp3- Fc (Igg) Dna Vaccine/Fusion Protein, Avicenna Journal of Medical Biotechnology (2016)
68. Dendritic Cell Based Immunotherapy Using Tumor Stem Cells Mediates Potent Antitumor Immune Responses, Cancer Letters (2016)
69. Downregulation of Cd73 in 4T1 Breast Cancer Cells Through Sirna-Loaded Chitosan-Lactate Nanoparticles, Tumor Biology (2016)
70. Epi-Drugs and Epi-Mirs: Moving Beyond Current Cancer Therapies, Current Cancer Drug Targets (2016)
71. Epi-Drugs and Epi-Mirs: Moving Beyond Current Cancer Therapies, Current Cancer Drug Targets (2016)
72. Identification of Proteins Derived From Listeria Monocytogenes Inducing Human Dendritic Cell Maturation, Tumor Biology (2016)
73. Improved Anti-Treg Vaccination Targeting Foxp3 Efficiently Decreases Regulatory T Cells in Mice, Journal of Immunotherapy (2016)
74. Improved Anti-Treg Vaccination Targeting Foxp3 Efficiently Decreases Regulatory T Cells in Mice, Journal of Immunotherapy (2016)
75. Inhibition of Hif-1Α Enhances Anti-Tumor Effects of Dendritic Cell-Based Vaccination in a Mouse Model of Breast Cancer, Cancer Immunology# Immunotherapy (2016)
76. Lactobacillus Crispatus Strain Sj-3C-Us Induces Human Dendritic Cells (Dcs) Maturation and Confers an Anti-Inflammatory Phenotype to Dcs, APMIS (2016)
77. Piggybac As a Novel Vector in Cancer Gene Therapy: Current Perspective, Cancer Gene Therapy (2016)
78. Piggybac As a Novel Vector in Cancer Gene Therapy: Current Perspective, Cancer Gene Therapy (2016)
79. Prospects for Chimeric Antigen Receptor (Car) Γδ T Cells: A Potential Game Changer for Adoptive T Cell Cancer Immunotherapy, Cancer Letters (2016)
80. Identification of Toxoplasma Gondii Protein Fractions Induce Immune Response Against Melanoma in Mice, APMIS (2015)
81. Inducing Humoral Immune Responses Against Regulatory T Cells by Foxp3-Fc(Igg) Fusion Protein, Monoclonal Antibodies in Immunodiagnosis and Immunotherapy (2015)
82. Low Noncytotoxic Concentrations of 5-Fluorouracil Have No Adverse Effects on Maturation and Function of Bone Marrow-Derived Dendritic Cells in Vitro: A Potentially Safe Adjuvant for Dendritic Cell-Based Cancer Therapy, International Archives of Allergy and Immunology (2015)
83. Low Noncytotoxic Concentrations of 5-Fluorouracil Have No Adverse Effects on Maturation and Function of Bone Marrow-Derived Dendritic Cells in Vitro: A Potentially Safe Adjuvant for Dendritic Cell-Based Cancer Therapy, International Archives of Allergy and Immunology (2015)
84. Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model, Iranian Journal of Immunology (2015)
85. Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model, Iranian Journal of Immunology (2015)
86. The Opposite Effects of Dna and Protein Components of Listeria Monocytogenes and Toxoplasma Gondii on Immunologic Characteristics of Dendritic Cells, Iranian Journal of Allergy# Asthma and Immunology (2015)
87. Frequencies of Cd4+ T Regulatory Cells and Their Cd25high and Foxp3high Subsets Augment in Peripheral Blood of Patients With Acute and Chronic Brucellosis, Osong Public Health and Research Perspectives (2014)