Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Creation of Tenecteplase-Producing Cho Cell Line Using Site-Specific Integrase From the Phage Φc31
Hamid Mirmohammad Sadeghi
Hamid Mirmohammad Sadeghi

Professor of Pharmaceutical Biotechnology

Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences

Pharmaceutical Sciences Research Center

Isfahan University of Medical Sciences

All Documents
1. Computational Design of Newly Engineered Darpins As Her2 Receptor Inhibitors for Breast Cancer Treatment, Research in Pharmaceutical Sciences (2023)
2. Gene Network Analysis of Oxaliplatin-Resistant Colorectal Cancer to Target a Crucial Gene Using Chitosan/Hyaluronic Acid/Protamine Polyplexes Containing Crispr-Cas9, Biochimica et Biophysica Acta - General Subjects (2023)
3. Smart Redox-Sensitive Micelles Based on Chitosan for Dasatinib Delivery in Suppressing Inflammatory Diseases, International Journal of Biological Macromolecules (2023)
4. Co-Expression of Chaperones for Improvement of Soluble Expression and Purification of an Anti-Her2 Scfv in Escherichia Coli, Advanced Biomedical Research (2022)
5. Ocular Delivery of Sunitinib-Loaded Nanoparticles Doped in Tragacanthic Acid Hydrogel in Treatment of Diabetic Retinopathy in Rats, Drug Development and Industrial Pharmacy (2022)
6. Design and Production of New Chimeric Reteplase With Enhanced Fibrin Affinity: A Theoretical and Experimental Study, Journal of Biomolecular Structure and Dynamics (2021)
7. Designing a New Bispecific Tandem Single-Chain Variable Fragment Antibody Against Tumor Necrosis Factor-Α and Interleukin-23 Using in Silico Studies for the Treatment of Rheumatoid Arthritis, Journal of Molecular Modeling (2020)
8. Investigation of Supercharging As a Strategy to Enhance the Solubility and Plasminogen Cleavage Activity of Reteplase, Iranian Journal of Biotechnology (2020)
9. Rational Design of a New Mutant of Tobacco Etch Virus Protease in Order to Increase the in Vitro Solubility, Research in Pharmaceutical Sciences (2020)
10. Shear Sensitive Injectable Hydrogels of Cross-Linked Tragacanthic Acid for Ocular Drug Delivery: Rheological and Biological Evaluation, International Journal of Biological Macromolecules (2020)
11. A Bi-Functional Targeted P28-Nrc Chimeric Protein With Enhanced Cytotoxic Effects on Breast Cancer Cell Lines, Iranian Journal of Pharmaceutical Research (2019)
12. Generation and Characterization of a Functional Nanobody Against Inflammatory Chemokine Cxcl10, As a Novel Strategy for the Treatment of Multiple Sclerosis, CNS and Neurological Disorders - Drug Targets (2019)
13. Improvement of Soluble Production of Reteplase in Escherichia Coli by Optimization of Chemical Chaperones in Lysis Buffer, Advanced Biomedical Research (2019)
14. Improving the Solubility, Activity, and Stability of Reteplase Using in Silico Design of New Variants, Research in Pharmaceutical Sciences (2019)
15. Optimization of Fermentation Conditions for Reteplase Expression by Escherichia Coli Using Response Surface Methodology, Avicenna Journal of Medical Biotechnology (2019)
16. Poly(Glycerol Sebacate) Nanoparticles for Ocular Delivery of Sunitinib: Physicochemical, Cytotoxic and Allergic Studies, IET Nanobiotechnology (2019)
17. Production of Novel Camelid Anti-Cxcl10 Specific Polyclonal Antibodies and Evaluation of Their Bioreactivity, International Journal of Peptide Research and Therapeutics (2019)
18. Improvement of Solubility and Refolding of an Anti-Human Epidermal Growth Factor Receptor 2 Single-Chain Antibody Fragment Inclusion Bodies, Research in Pharmaceutical Sciences (2018)
19. Improvement of Solubility and Refolding of an Anti-Human Epidermal Growth Factor Receptor 2 Single-Chain Antibody Fragment Inclusion Bodies, Research in Pharmaceutical Sciences (2018)
20. The Effect of Fads2 Gene Rs174583 Polymorphism on Desaturase Activities, Fatty Acid Profile, Insulin Resistance, Biochemical Indices, and Incidence of Type 2 Diabetes, Journal of Research in Medical Sciences (2018)
21. Efficient Media for High Lipase Production: One Variable at a Time Approach, Avicenna Journal of Medical Biotechnology (2017)
22. Study of the Role of Sirna Mediated Promoter Methylation in Dnmt3b Knockdown and Alteration of Promoter Methylation of Cdh1, Gstp1 Genes in Mda-Mb -453 Cell Line, Iranian Journal of Pharmaceutical Research (2017)
23. Synthesis and Cytotoxic Evaluation of Some New 3-(2-(2-Phenylthiazol-4-Yl) Ethyl)-Quinazolin-4(3H) One Derivatives With Potential Anticancer Effects, Research in Pharmaceutical Sciences (2017)
24. A Rapid and Sensitive Method for Ephb4 Identification As a Diagnostic and Therapeutic Biomarker in Invasive Breast Cancer, Journal of Cancer Research and Therapeutics (2016)
25. Optimization of Vasopressin Type 2 Receptor Expression in Escherichia Coli Bl21, Jundishapur Journal of Natural Pharmaceutical Products (2016)
26. Rational Development of a Polycistronic Plasmid With a Cpg-Free Bacterial Backbone As a Potential Tool for Direct Reprogramming, Cell Journal (2016)
27. Theoretical Design of a New Chimeric Protein for the Treatment of Breast Cancer, Research in Pharmaceutical Sciences (2016)
28. Twin Arginine Translocation System in Secretory Expression of Recombinant Human Growth Hormone, Research in Pharmaceutical Sciences (2016)
29. Association of Angiotensin-Converting Enzyme Genotype, Insertion/Deletion Polymorphism and Saphenous Vein Graft Atherosclerosis in Iranian Patients, Brazilian Journal of Cardiovascular Surgery (2015)
30. Effect of Mutations in Putative Hormone Binding Sites on V2 Vasopressin Receptor Function, Research in Pharmaceutical Sciences (2015)
31. Effect of Mutations in Putative Hormone Binding Sites on V2 Vasopressin Receptor Function, Research in Pharmaceutical Sciences (2015)
32. Improved Biological Activity of a Single Chain Antibody Fragment Against Human Epidermal Growth Factor Receptor 2 (Her2) Expressed in the Periplasm of Escherichia Coli, Protein Expression and Purification (2015)
33. Isolation and Characterization of a New Thermoalkalophilic Lipase From Soil Bacteria, Iranian Journal of Pharmaceutical Research (2015)
34. Long-Term and Efficient Expression of Human Β-Globin Gene in a Hematopoietic Cell Line Using a New Site-Specific Integrating Non-Viral System, Gene Therapy (2015)
35. Optimization of a Single-Chain Antibody Fragment Overexpression in Escherichia Coli Using Response Surface Methodology, Research in Pharmaceutical Sciences (2015)
36. Optimization of the Expression of Reteplase in Escherichia Coli Top10 Using Arabinose Promoter, Jundishapur Journal of Natural Pharmaceutical Products (2015)
37. Pharmacogenetic Association of Kcnj11 (E23k) Variant With Therapeutic Response to Sulphonylurea (Glibenclamide) in Iranian Patients, International Journal of Diabetes in Developing Countries (2015)
38. Study of V2 Vasopressin Receptor Hormone Binding Site Using in Silico Methods, Research in Pharmaceutical Sciences (2015)
39. Study of V2 Vasopressin Receptor Hormone Binding Site Using in Silico Methods, Research in Pharmaceutical Sciences (2015)
40. Functional Expression of a Single-Chain Antibody Fragment Against Human Epidermal Growth Factor Receptor 2 (Her2) in Escherichia Coli, Journal of Industrial Microbiology and Biotechnology (2014)
41. Inactivation of Apre Gene in Bacillus Subtilis 168 by Homologus Recombination, Avicenna Journal of Medical Biotechnology (2014)
42. The Effect of Infectious Disease Specialists Deployment Plan on Using Antibiotics in Alzahra Hospital, Isfahan, Iran, Journal of Isfahan Medical School (2014)
43. Association of Polymorphism of Ser311cys Paraoxonase-2 Gene With Type 2 Diabetes Mellitus in Iran, International Journal of Preventive Medicine (2013)
44. Cloning and Expression of Functional Reteplase in Escherichia Coli Top10, Avicenna Journal of Medical Biotechnology (2013)
45. Comparison of Bleomycin-Induced Pulmonary Apoptosis Between Nmri Mice and C57bl/6 Mice, Research in Pharmaceutical Sciences (2013)
46. Comparison of Five Methods for Extraction of Genomic Dna From a Marine Archaea, Pyrococcus Furiosus, Pakistan Journal of Medical Sciences (2013)
47. Comparison of the Cytoplasmic and Periplasmic Production of Reteplase in Escherichia Coli, Preparative Biochemistry and Biotechnology (2013)
48. Correlation Between Serum Parathyroid Hormone and Markers of Bone Metabolism in Hemodialysis Patients, Journal of Isfahan Medical School (2013)
49. Ephb4 Tyrosine Kinase Stimulation Inhibits Growth of Mda-Mb-231 Breast Cancer Cells in a Dose and Time Dependent Manner, Disease Markers (2013)
50. Expression of the Recombinant Plasminogen Activator (Reteplase) by a Non-Lytic Insect Cell Expression System, Research in Pharmaceutical Sciences (2013)
51. Investigating the Prevalence of Brca1 and Brca2 Gene Mutations in Patients With Breast Cancer, Journal of Isfahan Medical School (2013)
52. Isolation and Characterization of Novel Thermophilic Lipase-Secreting Bacteria, Brazilian Journal of Microbiology (2013)
53. Molecular Cloning and Expression of Reteplase in Escherichia Coli Using Tac Promoter, Journal of Isfahan Medical School (2013)
54. Preparation and Characterization of Oligochitosan-Tragacanth Nanoparticles As a Novel Gene Carrier, Carbohydrate Polymers (2013)
55. Quantitative Evaluation of Dnmt3b Promoter Methylation in Breast Cancer Patients Using Differential High Resolution Melting Analysis, Research in Pharmaceutical Sciences (2013)
56. Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and Occlusion of Vein Grafts in Long-Term Post-Cabg, Journal of Isfahan Medical School (2012)
57. Genetic Polymorphism of Leishmania Major in Two Hyper Endemic Regions of Iran Revealed by Ppip-Pcr and Its- Rflp, Archives of Iranian Medicine (2012)
58. Optimization of the Expression of Genes Encoding Poly (3-Hydroxyalkanoate) Synthase From Pseudomonas Aeruginosa Ptcc 1310 in Escherichia Coli, Avicenna Journal of Medical Biotechnology (2012)
59. Optimization of the Production and Purification of Taq Polymerase Enzyme Containing N666e Mutation in Its O-Helix Region, Journal of Isfahan Medical School (2012)
60. Preparation and Characterization of Micelles of Oligomeric Chitosan Linked to All-Trans Retinoic Acid, Carbohydrate Polymers (2012)
61. Two Dimensional Structural Analysis and Expression of a New Staphylococcus Aureus Adhesin Based Fusion Protein, Iranian Journal of Basic Medical Sciences (2012)
62. Expression of an Innate Immune Element (Mouse Hepcidin-1) in Baculovirus Expression System and the Comparison of Its Function With Synthetic Human Hepcidin-25, Iranian Journal of Pharmaceutical Research (2011)
63. Influence of the Timing of Cardiac Catheterization and Amount of Contrast Media on Acute Renal Failure After Cardiac Surgery, Journal of Research in Medical Sciences (2011)
64. Optimization of the Expression of Reteplase in Escherichia Coli, Research in Pharmaceutical Sciences (2011)
65. Polymorphism of Apolipoprotein E Gene and the Risk of Multiple Sclerosis, Journal of Research in Medical Sciences (2011)
66. Effect of Strontium Ions Substitution on Gene Delivery Related Properties of Calcium Phosphate Nanoparticles, Journal of Materials Science: Materials in Medicine (2010)
67. Mg2+Substituted Calcium Phosphate Nano Particles Synthesis for Non Viral Gene Delivery Application, Journal of Materials Science: Materials in Medicine (2010)
68. Molecular Detection of Lipase a Gene in Putative Bacillus Subtilis Strains Isolated From Soil, Iranian Journal of Biotechnology (2010)
69. Mutation of the Histidin Residue of the Drh Motif in Vasopressin V2 Receptor Expression and Function, DARU, Journal of Pharmaceutical Sciences (2010)
70. The Effect of Aspartate-Lysine-Isoleucine and Aspartate-Arginine-Tyrosine Mutations on the Expression and Activity of Vasopressin V2 Receptor Gene, Iranian Biomedical Journal (2010)
71. Tp53 Codon 72 Heterozygosity May Promote Microsatellite Instability in Sporadic Colorectal Cancer, Yakhteh (2010)
72. Cloning and Nucleotide Sequence of a Lipase Gene From a Soil Isolate, Research in Pharmaceutical Sciences (2009)
73. Construction of a New Fusion Protein Vector Associated to Fibronectin Binding Protein a and Clumping Factor a Derived From Staphylococcus Aureus Nctc8325, Iranian Journal of Basic Medical Sciences (2009)
74. Construction of Tenecteplase Coding Sequence by a Rapid Megaprimer Pcr Method and Its Cloning in a Mammary Gland Tissue Specific Expression Vector, Research in Pharmaceutical Sciences (2009)
75. Effects of Chronic Administration of Calcium-Magnesium Soft Gels on Morphine Tolerance and Dependence in Mice, Magnesium Research (2009)
76. Functional Expression of an Alkaline Lipase in Escherichia Coli, Annals of Microbiology (2009)
77. Premature Senescence of T Lymphocytes From Patients With Β-Thalassemia Major, Immunology Letters (2009)
78. Evidence for an Association of Tp53 Codon 72 Polymorphism With Sporadic Colorectal Cancer Risk in Isfahan, Journal of Research in Medical Sciences (2008)
79. Identification of an Isolate of Pseudomonas Aeroginosa Deposited in Ptcc As a Pha Producer Strain: Comparison of Three Different Bacterial Genomic Dna Extraction Methods, Journal of Biological Sciences (2008)
80. The Role of Strain Variation in Bax and Bcl-2 Expression in Murine Bleomycin-Induced Pulmonary Fibrosis, Pakistan Journal of Biological Sciences (2008)
81. Cloning and Expression of a Human Tissue Plasminogen Activator Variant: K2s in Escherichia Coli, Pakistan Journal of Biological Sciences (2007)
82. Cloning and Partial Sequencing of Phac1 and Phac2 Genes Encoding Poly (3-Hydroxyalkanoate) Synthases From Pseudomonas Aeroginusa Ptcc 1310, Biotechnology (2007)
83. Development and Time-Course of Bleomycin-Induced Pulmonary Fibrosis in Nmri Mice, Daru (2007)
84. Molecular Detection of Streptomyces Griseus Isolated From Isfahan Soil, Pakistan Journal of Biological Sciences (2007)
85. Protective Effects of Calcium-Magnesium Soft Gels in Morphine Tolerant and Dependent Mice, Magnesium Research (2006)