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Aberrant Expression of Plncrna-1 and Tug1: Potential Biomarkers for Gastric Cancer Diagnosis and Clinically Monitoring Cancer Progression Publisher Pubmed



Baratieh Z1 ; Khalaj Z1 ; Honardoost MA1, 2 ; Emadibaygi M3, 4 ; Khanahmad H1 ; Salehi M1 ; Nikpour P1, 5
Authors
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Authors Affiliations
  1. 1. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Division of Cellular and Molecular Biology, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
  3. 3. Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran
  4. 4. Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran
  5. 5. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Biomarkers in Medicine Published:2017


Abstract

Aim: To evaluate PlncRNA-1, TUG1 and FAM83H-AS1 gene expression and their possible role as a biomarker in gastric cancer (GC) progression. Patients & methods: Long noncoding RNA expressions and clinicopathological characteristics were assessed in 70 paired GC tissues. Furthermore, corresponding data from 318 GC patients were downloaded from The Cancer Genome Atlas database. Results: Expression of PlncRNA-1 and TUG1 were significantly upregulated in GC tumoral tissues, and significantly correlated with clinicopathological characters. However, FAM83H-AS1 showed no consistently differential expression. The expression of these three long noncoding RNAs was significantly higher in The Cancer Genome Atlas tumoral tissues. Conclusion: In conclusion, PlncRNA-1 and TUG1 genes may play a critical role in GC progression and may serve as potential diagnostic biomarkers in GC patients. © 2017 2017 Future Medicine Ltd.
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