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Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated From Newly Diagnosed and Ifn-ß 1B -Treated Ms Patients

Nafiseh Esmaeil

Nafiseh Esmaeil

Associate Professor of Medical Immunology

Department of Immunology, School of Medicine

Child Growth and Development Research Center

Research Institute for Primordial Prevention of Non-communicable Disease

Isfahan University of Medical Sciences

Related Documents

1. Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated From Newly Diagnosed and Ifn-ß 1B -Treated Ms Patients, Inflammation (2019)

2. Silymarin Impacts on Immune System As an Immunomodulator: One Key for Many Locks, International Immunopharmacology (2017)

3. Immunosuppressive Effect of Silymarin on Mitogen-Activated Protein Kinase Signalling Pathway: The Impact on T Cell Proliferation and Cytokine Production, Basic and Clinical Pharmacology and Toxicology (2013)

4. Significant Immunomodulatory and Hepatoprotective Impacts of Silymarin in Ms Patients: A Double-Blind Placebo-Controlled Clinical Trial, International Immunopharmacology (2021)

5. Silymarin Restores Regulatory T Cells (Tregs) Function in Multiple Sclerosis (Ms) Patients in Vitro, Inflammation (2019)

6. Expression of Nkg2d Receptors in Cd3+And Cd56+Cells in Blood Samples of Pre-Eclampsia Patients and the Effect of Silymarin on Their Activity in Vitro, Journal of Isfahan Medical School (2022)

7. Comparison of Follicular T Helper Cells, Monocytes, and T Cells Priming Between Newly Diagnosed and Rituximab-Treated Ms Patients and Healthy Controls, Research in Pharmaceutical Sciences (2022)

8. Evaluation of Soluble Human Leukocyte Antigen-G (Shla-G) Isoforms and Regulatory T Cells in Relapsing-Remitting Multiple Sclerosis, Iranian Journal of Allergy, Asthma and Immunology (2015)

9. Apamin As a Bbb Shuttle and Its Effects on T Cell Population During the Experimental Autoimmune Encephalomyelitis-Induced Model of Multiple Sclerosis, Neurotoxicity Research (2021)

10. Serum Levels of Tgfβ, Il-10, Il-17, and Il-23 Cytokines in Β-Thalassemia Major Patients: The Impact of Silymarin Therapy, Immunopharmacology and Immunotoxicology (2014)

All Documents

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8. Strong Capacity of Differentiated Pd-L1 Car-Modified Ucb-Cd34+ Cells and Pd-L1 Car-Modified Ucb-Cd34+-Derived Nk Cells in Killing Target Cells and Restoration of the Anti-Tumor Function of Pd-1-High Exhausted T Cells, Stem Cell Research and Therapy (2024)

9. A 2-Week Combined High-Intensity Interval Training Regulates Inflammatory Status in Young Females With Obesity; [Un Intervalle Training Combine a Haute Intensite De 2 Semaines Regule L’Etat Inflammatoire De Jeunes Femmes Obeses], Science and Sports (2023)

10. Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on Cd3+Cd8+Cd56+ Natural Killer T Population in Women With Recurrent Spontaneous Abortion, Journal of Human Reproductive Sciences (2023)

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12. Resistance Exercise Training Augments the Immunomodulatory Adaptations to Aerobic High-Intensity Interval Training, European Journal of Sport Science (2023)

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15. Association of Exposure to Particulate Matters and Multiple Sclerosis: A Systematic Review and Meta-Analysis, NeuroImmunoModulation (2022)

16. Comparison of Follicular T Helper Cells, Monocytes, and T Cells Priming Between Newly Diagnosed and Rituximab-Treated Ms Patients and Healthy Controls, Research in Pharmaceutical Sciences (2022)

17. Comparison of Follicular T Helper Cells, Monocytes, and T Cells Priming Between Newly Diagnosed and Rituximab-Treated Ms Patients and Healthy Controls, Research in Pharmaceutical Sciences (2022)

18. Comparison of Four Methods of Colon Cancer Cell Lysates Preparation for Ex Vivo Maturation of Dendritic Cells, Research in Pharmaceutical Sciences (2022)

19. Diagnostic Value of Natural Killer Cells, Cd56+ Cd16+ Natural Killer Cells, Nlrp3, and Lactate Dehydrogenase in Severe/Critical Covid-19: A Prospective Longitudinal Study According to the Severe/Critical Covid-19 Definitions, Viral Immunology (2022)

20. Expression of Nkg2d Receptors in Cd3+And Cd56+Cells in Blood Samples of Pre-Eclampsia Patients and the Effect of Silymarin on Their Activity in Vitro, Journal of Isfahan Medical School (2022)

21. Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats, Advanced Biomedical Research (2022)

22. Apamin As a Bbb Shuttle and Its Effects on T Cell Population During the Experimental Autoimmune Encephalomyelitis-Induced Model of Multiple Sclerosis, Neurotoxicity Research (2021)

23. Phycocyanin C a Natural Product With Impressive Therapeutic Efficacy for Inhibition of Breast Tumors’ Growth and Metastasis in Vivo, Middle East Journal of Cancer (2021)

24. Research Paper: Anti-Myelin Oligodendrocyte Glycoprotein in Aquaporin-4 Negative Neuromyelitis Optica Spectrum Disorder, Caspian Journal of Neurological Sciences (2021)

25. Significant Immunomodulatory and Hepatoprotective Impacts of Silymarin in Ms Patients: A Double-Blind Placebo-Controlled Clinical Trial, International Immunopharmacology (2021)

26. Significant Immunomodulatory and Hepatoprotective Impacts of Silymarin in Ms Patients: A Double-Blind Placebo-Controlled Clinical Trial, International Immunopharmacology (2021)

27. The Role of Distinct Subsets of Macrophages in the Pathogenesis of Ms and the Impact of Different Therapeutic Agents on These Populations, Frontiers in Immunology (2021)

28. Assessment of the Effect of Short-Term Combined High-Intensity Interval Training on Tlr4, Nf-Κb and Irf3 Expression in Young Overweight and Obese Girls, Public Health Genomics (2020)

29. Combined All-Extremity High-Intensity Interval Training Regulates Immunometabolic Responses Through Toll-Like Receptor 4 Adaptors and A20 Downregulation in Obese Young Females, Obesity Facts (2020)

30. Evaluation of the Effect of Gm-Csf Blocking on the Phenotype and Function of Human Monocytes, Scientific Reports (2020)

31. Increased Expression of B Lymphocyte Induced Maturation Protein 1 (Blimp1) in Patients With Common Variable Immunodeficiency (Cvid), Iranian Journal of Allergy# Asthma and Immunology (2020)

32. Increased Expression of B Lymphocyte Induced Maturation Protein 1 (Blimp1) in Patients With Common Variable Immunodeficiency (Cvid), Iranian Journal of Allergy, Asthma and Immunology (2020)

33. Meta-Inflammatory State and Insulin Resistance Can Improve After 10 Weeks of Combined All-Extremity High-Intensity Interval Training in Sedentary Overweight/Obese Females: A Quasi-Experimental Study, Journal of Diabetes and Metabolic Disorders (2020)

34. Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline, European Addiction Research (2020)

35. Omega 3 Supplementation Can Regulate Inflammatory States in Gas Station Workers: A Double-Blind Placebo-Controlled Clinical Trial, Journal of Interferon and Cytokine Research (2020)

36. Optimization of in Vitro Expansion and Activation of Human Natural Killer Cells Against Breast Cancer Cell Line, Avicenna Journal of Medical Biotechnology (2020)

37. The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions, Diabetes, Metabolic Syndrome and Obesity (2020)

38. Effect of Fish Oil on the Level of Interferon Gamma on the Breast Milk of Atopic Mothers: A Randomized Clinical Trial, Iranian Journal of Neonatology (2019)

39. Immunoregulatory Effects of Human Amnion Epithelial Cells on Natural Killer and T Cells in Women With Recurrent Spontaneous Abortion (Rsa); [Tekrarlayan Gebelik Kaybi Olan Kadinlarda Insan Amniyon Epitel Hucrelerinin Dogal Oldurucu Ve T Lenfositleri Uzerine Olan Etkisi], Turkish Journal of Immunology (2019)

40. Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated From Newly Diagnosed and Ifn-ß 1B -Treated Ms Patients, Inflammation (2019)

41. Increased Irf4 Expression in Isolated B Cells From Common Variable Immunodeficiency (Cvid) Patients, Allergologia et Immunopathologia (2019)

42. Increased Irf4 Expression in Isolated B Cells From Common Variable Immunodeficiency (Cvid) Patients, Allergologia et Immunopathologia (2019)

43. Producing Soluble Human Programmed Cell Death Protein-1: A Natural Supporter for Cd4+T Cell Cytotoxicity and Tumor Cells Apoptosis, Iranian Journal of Biotechnology (2019)

44. Roles of Gm-Csf in the Pathogenesis of Autoimmune Diseases: An Update, Frontiers in Immunology (2019)

45. Silymarin Restores Regulatory T Cells (Tregs) Function in Multiple Sclerosis (Ms) Patients in Vitro, Inflammation (2019)

46. An 8-Year Study of People With Multiple Sclerosis in Isfahan, Iran: Association Between Environmental Air Pollutants and Severity of Disease, Journal of Neuroimmunology (2018)

47. Decreased Serum Levels of Interleukin-35 Among Multiple Sclerosis Patients May Be Related to Disease Progression, Journal of Biological Regulators and Homeostatic Agents (2018)

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49. High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction After Thymectomy, NeuroImmunoModulation (2018)

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51. Increased Proportion of Tc17 and Th17 Cells and Their Significant Reduction After Thymectomy May Be Related to Disease Progression in Myasthenia Gravis, NeuroImmunoModulation (2018)

52. Lower Extremity Deep Venous Thrombosis in a Multiple Sclerosis Patient on Dimethyl Fumarate, Multiple Sclerosis and Related Disorders (2018)

53. Seroprevalence of Toxocaracanis in Asthmatic Children and Its Relation to the Severity of Diseases - a Case-Control Study, Medical archives (Sarajevo, Bosnia and Herzegovina) (2018)

54. The Immunomodulatory Effects of Human Amniotic Epithelial Cells on Peripheral Blood Natural Killer T (Nkt) Cells in Women With Unexplained Recurrent Spontaneous Abortion (Ursa), Journal of Isfahan Medical School (2018)

55. The Interplay of Multiple Sclerosis and Menstrual Cycle: Which One Affects the Other One?, Multiple Sclerosis and Related Disorders (2018)

56. Assessment of the Expression Level of B-Cell Lymphoma 6 (Bcl6) in Peripheral Blood Cd38+ B Lymphocytes in Patients With Common Variable Immunodeficiency (Cvid), Journal of Isfahan Medical School (2017)

57. Assessment of the Expression Level of B-Cell Lymphoma 6 (Bcl6) in Peripheral Blood Cd38+ B Lymphocytes in Patients With Common Variable Immunodeficiency (Cvid), Journal of Isfahan Medical School (2017)

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60. Method and Key Points for Isolation of Human Amniotic Epithelial Cells With High Yield, Viability and Purity, BMC Research Notes (2017)

61. Silymarin Impacts on Immune System As an Immunomodulator: One Key for Many Locks, International Immunopharmacology (2017)

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64. Evaluation of Soluble Human Leukocyte Antigen-G (Shla-G) Isoforms and Regulatory T Cells in Relapsing-Remitting Multiple Sclerosis, Iranian Journal of Allergy, Asthma and Immunology (2015)

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67. Serum Levels of Tgfβ, Il-10, Il-17, and Il-23 Cytokines in Β-Thalassemia Major Patients: The Impact of Silymarin Therapy, Immunopharmacology and Immunotoxicology (2014)

68. Study of Carbon Nano-Tubes Effects on the Chondrogenesis of Human Adipose Derived Stem Cells in Alginate Scaffold, International Journal of Preventive Medicine (2014)

69. A Randomized Double-Blind, Placebo-Controlled Study of Therapeutic Effects of Silymarin in Β-Thalassemia Major Patients Receiving Desferrioxamine, European Journal of Haematology (2013)

70. Comparison Between Chondrogenic Markers of Differentiated Chondrocytes From Adipose Derived Stem Cells and Articular Chondrocytes in Vitro, Iranian Journal of Basic Medical Sciences (2013)

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72. Comparison of the Production of Extracellular Matrix in Nucleus Pulposus of Intervertebral Disc in Alginate and Chitosan-Gelatin Scaffolds, Journal of Isfahan Medical School (2013)

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74. Immunosuppressive Effect of Silymarin on Mitogen-Activated Protein Kinase Signalling Pathway: The Impact on T Cell Proliferation and Cytokine Production, Basic and Clinical Pharmacology and Toxicology (2013)

75. Suppressive Impact of Anethum Graveolens Consumption on Biochemical Risk Factors of Atherosclerosis in Hypercholesterolemic Rabbits, International Journal of Preventive Medicine (2013)

76. The Apoptotic Effects of Sirtuin1 Inhibitor on the Mcf-7 and Mrc-5 Cell Lines, Research in Pharmaceutical Sciences (2013)

77. Serum Monocyte Chemotactic Protein-1 and Nitric Oxide in Cutaneous Leishmaniasis Patients Before and After Treatment With Glucantime, Journal of Isfahan Medical School (2012)

78. Serum Monocyte Chemotactic Protein-1 and Nitric Oxide in Cutaneous Leishmaniasis Patients Before and After Treatment With Glucantime, Journal of Isfahan Medical School (2012)

79. The Role of Maternal Thyroid Stimulating Hormone Receptor Blocking Antibodies in the Etiology of Congenital Hypothyroidism in Isfahan, Iran, International Journal of Preventive Medicine (2012)

80. Ifn-Γ, Il-4 and Il-17 Concentration in Tumor Tissue, Adjacent Tumor Tissue and the Serums of Patients With Breast Cancer, Journal of Isfahan Medical School (2011)

81. The Role of Maternal Tsh Receptor Blocking Antibody in the Etiology of Congenital Hypothyroidism in Isfahan, Journal of Isfahan Medical School (2011)

82. Phenotypic Characterizations and Comparison of Adult Dental Stem Cells With Adipose-Derived Stem Cells, International Journal of Preventive Medicine (2010)