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Efficient Synthesis of 2-Methylenethiazolo[2,3- B ]Quinazolinone Derivatives Publisher



Mahdavi M1 ; Bialam M2 ; Saeedi M3 ; Jafarpour F2 ; Foroumadi A1 ; Shafiee A1
Authors

Source: Synlett Published:2015


Abstract

Substituted o-Amino-N-(prop-2-yn-1-yl) aromatic amides easily reacted with carbon disulfide (CS2) in the presence of potassium hydroxide (KOH) in EtOH under reflux conditions. Cyclization reaction followed by a favored 5-exo-dig ring closure afforded 2-methylene-thiazolo[2,3-b]quinazolinone derivatives in good yields. © Georg Thieme Verlag Stuttgart New York.
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