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Efficient Three-Component Synthesis of N-Alkyl-3, 6-Diaryl-[1, 2, 4]Triazolo[4, 3-B][1, 2, 4]Triazin-7-Amines Under Solvent-Free Condition Publisher



Azimi S1 ; Soheilizad M2 ; Zonouzi A1 ; Mahdavi M2
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: Arkivoc Published:2017


Abstract

A simple, efficient and environment-friendly approach is described for the synthesis of N-alkyl-3, 6-diaryl-[1, 2, 4]triazolo[4, 3-b][1, 2, 4]triazin-7-amines based on three-component reaction between 5-aryl-4H-1, 2, 4-triazole-3, 4-diamine, isocyanide and aldeyhde under solvent-free condition. The products are obtained in moderate to good yields and are in a state of high purity. © ARKAT USA, Inc.