Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Optimized Protocol for Soluble Prokaryotic Expression, Purification and Structural Analysis of Human Placenta Specific-1(Plac1)
Seyed Nasser Ostad
Seyed Nasser Ostad

Professor of Pharmacology and Toxicology

Department Pharmaceutical Biomaterials

School of Pharmacy

Tehran University of Medical Sciences

Related Documents
1. Expression Profiling of Plac1 in Murine Cancer Cell Lines, Experimental Oncology (2019)
2. Expression of Human Placenta-Specific 1 (Plac1) in Cho-K1 Cells, Avicenna Journal of Medical Biotechnology (2020)
3. Plac1: Biology and Potential Application in Cancer Immunotherapy, Cancer Immunology# Immunotherapy (2019)
All Documents
1. Development of a Nanoemulsion Incorporating 3-Acetyl-11-Keto-Β-Boswellic Acid (Akba): Solubility and Oral Bioavailability Through in Vitro and in Vivo Studies, BMC Biotechnology (2026)
2. Advancing Burn Wound Healing With an Innovative in Situ Gelling Probiotic Microparticle Formulation Employing Quality by Design (Qbd) Principles, Journal of Tissue Viability (2025)
3. Co-Delivery of Sn38 and Rapamycin Albumin Bound Nanoparticles Against Breast Cancer, DARU, Journal of Pharmaceutical Sciences (2025)
4. Combating Drug Resistance in Lung Cancer: Exploring the Synergistic Potential of Metformin and Cisplatin in a Novel Combination Therapy; a Systematic Review, Current Topics in Medicinal Chemistry (2025)
5. Elucidating the Inhibitory Potential of Statins Against Oncogenic C-Met Tyrosine Kinase Through Computational and Cell-Based Studies, Iranian Journal of Pharmaceutical Research (2025)
6. Elucidating the Inhibitory Potential of Statins Against Oncogenic C-Met Tyrosine Kinase Through Computational and Cell-Based Studies, Iranian Journal of Pharmaceutical Research (2025)
7. Prenatal Exposure to Methamphetamine and Its Association With Birth Outcomes: A Meta-Analysis, Birth Defects Research (2025)
8. Scientists Collaboration for Science Development and Peace: Usern View, Acta Medica Iranica (2025)
9. Targeting Cancer Stem Cells and Hedgehog Pathway: Enhancing Cisplatin Efficacy in Ovarian Cancer With Metformin, Journal of Cellular and Molecular Medicine (2025)
10. The Clinical Potentials of Combining Paclitaxel-Based Chemotherapy Regimen With Metformin in Cancer Treatment: A Systematic Review and Meta-Analysis, Translational Oncology (2025)
11. Therapeutic Potential of an Anti-Plac1 Antibody Drug Conjugate in a Murine Model of Human Breast Cancer, Iranian Journal of Immunology (2025)
12. Chitosan Based Extruded Nanofibrous Bioscaffold for Local Delivery Of Mesenchymal Stem Cells To Improve Diabetic Wound Healing, Stem Cell Research and Therapy (2024)
13. Development a Novel Nano-Platform for Thrombolysis Acceleration by Thrombin Sensitive Polymer-Peptide Hybrid Nancapsules, International Journal of Pharmaceutics (2024)
14. Examining the Relationship Between Per-And Polyfluoroalkyl Substances and Breast, Colorectal, Prostate, and Ovarian Cancers: A Meta-Analysis, Critical Reviews in Toxicology (2024)
15. Preparation, Optimization and in Vitro Characterization of Fluticasoneloaded Mixed Micelles Based on Stearic Acid-G-Chitosan As a Pulmonary Delivery System, Recent Advances in Drug Delivery and Formulation (2024)
16. Therapeutic Potential of Crocin and Nobiletin in a Mouse Model of Dry Eye Disease: Modulation of the Inflammatory Response and Protection of the Ocular Surface, Iranian Journal of Pharmaceutical Research (2024)
17. Using Chitosan-Coated Magnetite Nanoparticles As a Drug Carrier for Opioid Delivery Against Breast Cancer, Pharmaceutical Development and Technology (2024)
18. Combination Effect of Doxorubicin and Hif Inhibitor on Mcf-7 Cd44+/Cd24-Subpopulation Cells in Hypoxic Condition, Brazilian Journal of Pharmaceutical Sciences (2022)
19. Modification of the Hemodynamic and Molecular Features of Phosphine, a Potent Mitochondrial Toxicant in the Heart, by Cannabidiol, Toxicology Mechanisms and Methods (2022)
20. Review on Approved and Inprogress Covid-19 Vaccines, Iranian Journal of Pharmaceutical Research (2022)
21. Unraveling Potential Candidate Targets Associated With Expression of P16ink4a or P16 Truncated Fragment by Comparative Proteomics Analysis, Current Proteomics (2022)
22. Bisphenol-A in Biological Samples of Breast Cancer Mastectomy and Mammoplasty Patients and Correlation With Levels Measured in Urine and Tissue, Scientific Reports (2021)
23. Comparison of Insulin Secretion by Transduced Adipose-Derived and Endometrial-Derived Stem Cells in 2D and 3D Cultures on Fibrin Scaffold, Journal of Biomedical Materials Research - Part A (2021)
24. Electrocardiographic, Hemodynamic, and Biochemical Evidence on the Protective Effects of Exenatide Against Phosphine-Induced Cardiotoxicity in Rat Model, Human and Experimental Toxicology (2021)
25. Exosomes Derived From Mir-34A-Overexpressing Mesenchymal Stem Cells Inhibit in Vitro Tumor Growth: A New Approach for Drug Delivery, Life Sciences (2021)
26. Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds With a Multifunctional Wound Dressing, Molecular Pharmaceutics (2021)
27. Synthesis, Biological Evaluation and Docking Study of New Pyrimidine Compounds As Anticancer Agents, Drug Research (2021)
28. Synthesis, Evaluation of Biological Activity, Docking and Molecular Dynamic Studies of Pyrimidine Derivatives, Letters in Organic Chemistry (2021)
29. A Narrative Review of Current Trends in Liraglutide: Insights Into the Unmet Needs in Management of Type 2 Diabetes and Obesity, Journal of Diabetes and Metabolic Disorders (2020)
30. A Preliminary Study of Ner and Mmr Pathways Involved in Chemotherapy Response in Bladder Transitional Cell Carcinoma: Impact on Progression-Free Survival, Iranian Journal of Pharmaceutical Research (2020)
31. Delivery of Injectable Thermo-Sensitive Hydrogel Releasing Nerve Growth Factor for Spinal Cord Regeneration in Rat Animal Model, Journal of Tissue Viability (2020)
32. Design, Synthesis and In-Vitro Anti-Cancer Evaluation of Novel Derivatives of 2-(2-Methyl-1,5-Diaryl-1H-Pyrrol-3-Yl)-2-Oxo-N-(Pyridin-3-Yl)Acetamide, Medicinal Chemistry (2020)
33. Expression of Human Placenta-Specific 1 (Plac1) in Cho-K1 Cells, Avicenna Journal of Medical Biotechnology (2020)
34. Ficus Carica L. Latex: Possible Chemo-Preventive, Apoptotic Activity and Safety Assessment, Iranian Journal of Pharmaceutical Research (2020)
35. Impact of Plasma Concentration of Transferrin on Targeting Capacity of Nanoparticles, Nanoscale (2020)
36. In Vivo Evaluation of Carvedilol Cardiac Protection Against Trastuzumab Cardiotoxicity, Drug Research (2020)
37. Peptide-Conjugated Liposomes for Targeted Mir-34A Delivery to Suppress Breast Cancer and Cancer Stem-Like Population, Journal of Drug Delivery Science and Technology (2020)
38. Pharmacological Properties of Pt(Ii) and Pt(Iv) Complexes With 2,2′-Dipyridylamine; the Comparative in Vitro Thereof, Cell Biochemistry and Biophysics (2020)
39. Potential of Treated Dentin Matrix Xenograft for Dentin-Pulp Tissue Engineering, Journal of Endodontics (2020)
40. Protective Role of Egcg Against Malathion Induced Genotoxicity Using Human Lymphocytes, Drug Research (2020)
41. Proteomics Analysis of Trastuzumab Toxicity in the H9c2 Cardiomyoblast Cell Line and Its Inhibition by Carvedilol, Current Pharmaceutical Biotechnology (2020)
42. Pulp Ecm-Derived Macroporous Scaffolds for Stimulation of Dental-Pulp Regeneration Process, Dental Materials (2020)
43. Targeting Tumorigenicity of Breast Cancer Stem Cells Using Saha/Wnt-B Catenin Antagonist Loaded Onto Protein Corona of Gold Nanoparticles, International Journal of Nanomedicine (2020)
44. The Inhibitory Effect of Curcumin on Hypoxia Inducer Factors (Hifs) As a Regulatory Factor in the Growth of Tumor Cells in Breast Cancer Stem-Like Cells, Drug Research (2020)
45. Anticancer Properties of N-Alkyl-2, 4-Diphenylimidazo [1, 2-A] Quinoxalin-1-Amine Derivatives; Kinase Inhibitors, Bioorganic Chemistry (2019)
46. Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells, Iranian Biomedical Journal (2019)
47. Calligonum Comosum (Escanbil) Extract Exerts Anti-Angiogenic, Anti-Proliferative and Anti-Inflammatory Effects on Endometriotic Lesions, Journal of Ethnopharmacology (2019)
48. Design and Characterization of Biodegradable Multi Layered Electrospun Nanofibers for Corneal Tissue Engineering Applications, Journal of Biomedical Materials Research - Part A (2019)
49. Design, Synthesis and Anticancer Evaluation of Novel Series of Indibulin Analogues, Medicinal Chemistry (2019)
50. Expression Profiling of Plac1 in Murine Cancer Cell Lines, Experimental Oncology (2019)
51. High Glucose Affects the Cytotoxic Potential of Rapamycin, Metformin and Hydrogen Peroxide in Cultured Human Mesenchymal Stem Cells, Current Molecular Medicine (2019)
52. Invasion and Migration of Mda-Mb-231 Cells Are Inhibited by Block of Ahr and Nfat: Role of Ahr/Nfat1/Β4 Integrin Signaling, Journal of Applied Toxicology (2019)
53. Mesenchymal Stem Cell Exosomes: A Two-Edged Sword in Cancer Therapy, International Journal of Nanomedicine (2019)
54. N-Terminal Domain of Fragile Histidine Triad Exerts Potent Cytotoxic Effect in Ht1080 Cells and Increases Doxorubicin Cytotoxicity, Iranian Journal of Pharmaceutical Research (2019)
55. Photobleaching Comparison of R-Phycoerythrin-Streptavidin and Streptavidin-Alexa Fluor 568 in a Breast Cancer Cell Line, Monoclonal Antibodies in Immunodiagnosis and Immunotherapy (2019)
56. Plac1: Biology and Potential Application in Cancer Immunotherapy, Cancer Immunology# Immunotherapy (2019)
57. Synthesis, Anti-Proliferative Evaluation, and Molecular Docking Studies of 3-(Alkylthio)-5,6-Diaryl-1,2,4-Triazines As Tubulin Polymerization Inhibitors, Letters in Drug Design and Discovery (2019)
58. The Influence of the Nonleaving Group on the Anticancer Activity of Tetrachlorido Platinum(Iv) Complexes With Pyridine/Bipyridine Derivatives, Inorganica Chimica Acta (2019)
59. Design, Synthesis and Cytotoxicity Evaluation of Indibulin Analogs, Heterocyclic Communications (2018)
60. Effect of the Estrus Cycle Stage on the Establishment of Murine Endometriosis Lesions, International Journal of Reproductive BioMedicine (2018)
61. Evaluation of Genistein Effect on Invasion of Breast Cancer Stem Cell-Like Cells, Acta Medica Iranica (2018)
62. Identification of Phytochemicals Targeting C-Met Kinase Domain Using Consensus Docking and Molecular Dynamics Simulation Studies, Cell Biochemistry and Biophysics (2018)
63. Phytochemicals, Withaferin a and Carnosol, Overcome Pancreatic Cancer Stem Cells As C-Met Inhibitors, Biomedicine and Pharmacotherapy (2018)
64. Rapamycin-Loaded, Capryol™ 90 and Oleic Acid Mediated Nanoemulsions: Formulation Development, Characterization and Toxicity Assessment, Iranian Journal of Pharmaceutical Research (2018)
65. Role of Nitric Oxide and Metallothionein in Cytotoxic Activity of Cadmium in Caco-2 Cells, Acta Medica Iranica (2018)
66. Tolerance Induction by Surface Immobilization of Jagged-1 for Immunoprotection of Pancreatic Islets, Biomaterials (2018)
67. Toxicity Evaluation of Aromatic Water of Pinus Eldarica Medw. in Acute and Sub-Chronic Toxicity Experiments, Progress in Nutrition (2018)
68. Toxicity Evaluation of Essential Oil of Trachyspermum Ammi in Acute and Sub-Chronic Toxicity Experiments, Journal of Medicinal Plants (2018)
69. Anti-Invasion Effects of Cannabinoids Agonist and Antagonist on Human Breast Cancer Stem Cells, Iranian Journal of Pharmaceutical Research (2017)
70. Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy, Artificial Cells# Nanomedicine and Biotechnology (2017)
71. Doxorubicin-Loaded Liposomes: Enhancing the Oral Bioavailability by Modulation of Physicochemical Characteristics, Nanomedicine (2017)
72. Effect of Metformin and Celecoxib on Cytotoxicity and Release of Gdf-15 From Human Mesenchymal Stem Cells in High Glucose Condition, Cell Biochemistry and Function (2017)
73. Effects of Celecoxib and L-Name on Apoptosis and Cell Cycle of Mcf-7 Cd44+/Cd24-/Low Subpopulation, Turkish Journal of Biology (2017)
74. On the Mechanisms of Melatonin in Protection of Aluminum Phosphide Cardiotoxicity, Archives of Toxicology (2017)
75. Sn38 Conjugated Hyaluronic Acid Gold Nanoparticles As a Novel System Against Metastatic Colon Cancer Cells, International Journal of Pharmaceutics (2017)
76. Sub-Chronic Oral Toxicity of Cuminum Cyminum L.’S Essential Oil in Female Wistar Rats, Regulatory Toxicology and Pharmacology (2017)
77. Truncated Forms of Runx3 Unlike Full Length Protein Alter Cell Proliferation in a Tgf-Β Context Dependent Manner, Iranian Journal of Pharmaceutical Research (2017)
78. Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial, Acta Medica Iranica (2016)
79. Cytotoxic Potential of Centaurea Bruguierana Ssp. Belangerana: The Mtt Assay, Acta Medica Iranica (2016)
80. Cytotoxicity and Dna/Bsa Binding Ability of Copper(Ii) Complexes With Dimethylbithiazole, Monatshefte fur Chemie (2016)
81. Influence of Methyl Group Position in Bipyridine Ligand on Structure and Luminescence of Related Zinc(Ii) Nitrate Complexes, Journal of the Iranian Chemical Society (2016)
82. Investigation of Simvastatin-Induced Apoptosis and Cell Cycle Arrest in Cancer Stem Cells of Mcf-7, Journal of Cancer Research and Therapeutics (2016)
83. Mesoporous Silica Nanoparticles Functionalized With Folic Acid/Methionine for Active Targeted Delivery of Docetaxel, OncoTargets and Therapy (2016)
84. Minocycline Effects on Il-6 Concentration in Macrophage and Microglial Cells in a Rat Model of Neuropathic Pain, Iranian Biomedical Journal (2016)
85. Molecular and Biochemical Evidence on the Protection of Cardiomyocytes From Phosphine-Induced Oxidative Stress, Mitochondrial Dysfunction and Apoptosis by Acetyl-L-Carnitine, Environmental Toxicology and Pharmacology (2016)
86. Self Assembled Hyaluronic Acid Nanoparticles As a Potential Carrier for Targeting the Inflamed Intestinal Mucosa, Carbohydrate Polymers (2016)
87. Synthesis of Calcium Phosphate-Zirconia Scaffold and Human Endometrial Adult Stem Cells for Bone Tissue Engineering, Artificial Cells# Nanomedicine and Biotechnology (2016)
88. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 1,3,5-Triaryl Pyrazole Derivatives, Letters in Drug Design and Discovery (2016)
89. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-Diaryl-5-(4-Pyridinyl)-1,2,4-Oxadiazole, Medicinal Chemistry (2016)
90. The Effect of Benzo[Α]Pyrene on Expression and Signaling Cross Talk of Aryl Hydrocarbon Receptor and Nfatc1 in Mouse Lung Tissue, Toxicology and Industrial Health (2016)
91. Thermoresponsive Polyurethane/Siloxane Membrane for Wound Dressing and Cell Sheet Transplantation: In-Vitro and In-Vivo Studies, Materials Science and Engineering C (2016)
92. Ameliorating of Memory Impairment and Apoptosis in Amyloid Β-Injected Rats Via Inhibition of Nitric Oxide Synthase: Possible Participation of Autophagy, Iranian Journal of Pharmaceutical Research (2015)
93. An Electrocardiographic, Molecular and Biochemical Approach to Explore the Cardioprotective Effect of Vasopressin and Milrinone Against Phosphide Toxicity in Rats, Food and Chemical Toxicology (2015)
94. Biological Activities and Composition of Ferulago Carduchorum Essential Oil, Journal of Arthropod-Borne Diseases (2015)
95. Cell Cycle Arrest and Apoptogenic Properties of Opium Alkaloids Noscapine and Papaverine on Breast Cancer Stem Cells, Toxicology Mechanisms and Methods (2015)
96. Development of Acid-Resistant Alginate/Trimethyl Chitosan Nanoparticles Containing Cationic Β-Cyclodextrin Polymers for Insulin Oral Delivery, AAPS PharmSciTech (2015)
97. Effects of Berberine on Proliferation, Cell Cycle Distribution and Apoptosis of Human Breast Cancer T47d and Mcf7 Cell Lines, Iranian Journal of Basic Medical Sciences (2015)
98. Effects of Teratogenic Drugs on Cyp1a1 Activity in Differentiating Rat Embryo Cells, Drug Research (2015)
99. Electrophysiological and Molecular Mechanisms of Protection by Iron Sucrose Against Phosphine-Induced Cardiotoxicity: A Time Course Study, Toxicology Mechanisms and Methods (2015)
100. Formulation Development and Toxicity Assessment of Triacetin Mediated Nanoemulsions As Novel Delivery Systems for Rapamycin, Iranian Journal of Pharmaceutical Research (2015)
101. From Proton Transferred to Cyclometalated Platinum(Iv) Complex: Crystal Structure and Biological Activity, Journal of Organometallic Chemistry (2015)
102. Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa, Acta medica Iranica (2015)
103. Growth Inhibition of Mda-Mb-231 Cell Line by Peptides Designed Based on Upa, Acta Medica Iranica (2015)
104. Improved Anticancer Delivery of Paclitaxel by Albumin Surface Modification of Plga Nanoparticles, DARU# Journal of Pharmaceutical Sciences (2015)
105. Non-Addictive Opium Alkaloids Selectively Induce Apoptosis in Cancer Cells Compared to Normal Cells, DARU# Journal of Pharmaceutical Sciences (2015)
106. Overexpression of Cyclin E and Its Low Molecular Weight Isoforms Cooperate With Loss of P53 in Promoting Oncogenic Properties of Mcf-7 Breast Cancer Cells, Asian Pacific Journal of Cancer Prevention (2015)
107. Pi3k/Akt Inhibition and Down-Regulation of Bcrp Re-Sensitize Mcf7 Breast Cancer Cell Line to Mitoxantrone Chemotherapy, Iranian Journal of Basic Medical Sciences (2015)
108. Polymeric Micelles of Peg-Pla Copolymer As a Carrier for Salinomycin Against Gemcitabine-Resistant Pancreatic Cancer, Pharmaceutical Research (2015)
109. Protein Corona Hampers Targeting Potential of Muc1 Aptamer Functionalized Sn-38 Core-Shell Nanoparticles, International Journal of Pharmaceutics (2015)
110. Quercetin Induces Cell Cycle Arrest and Apoptosis in Cd133+ Cancer Stem Cells of Human Colorectal Ht29 Cancer Cell Line and Enhances Anticancer Effects of Doxorubicin, Iranian Journal of Basic Medical Sciences (2015)
111. Synthesis and Anticancer Activity of 1,3,5-Triaryl-1H-Pyrazole, Letters in Drug Design and Discovery (2015)
112. Synthesis and Evaluation of Anti-Inflammatory and Analgesic Activities of New 1,2,4-Triazole Derivatives, Medicinal Chemistry (2015)
113. The Neuroprotective Effect of Lithium in Cannabinoid Dependence Is Mediated Through Modulation of Cyclic Amp, Erk1/2 and Gsk-3Β Phosphorylation in Cerebellar Granular Neurons of Rat, Iranian Journal of Pharmaceutical Research (2015)
114. Upar Peptide Antagonist Alters Regulation of Map Kinases and Bcl-2 Family Members in Favor of Apoptosis in Mda-Mb-231 Cell Line, Research in Pharmaceutical Sciences (2015)