Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One

Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One Publisher

Mahdavi M¹ ; Saeedi M^{2, 3} ; Karimi M⁴ ; Foroughi N⁴ ; Hasanshahi F¹ ; Alinezhad H⁵ ; Foroumadi A⁴ ; Shafiee A⁴ ; Akbarzadeh T^{3, 6}

Show Affiliations

1. Faculty of Pharmacy, International Campus (TUMS-IC), Tehran University of Medical Sciences, Tehran, Iran
2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
6. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Monatshefte fur Chemie Published:2016

Abstract

Abstract: This work reports an efficient route for the synthesis of novel 1,2,3-triazole derivatives of 2,3-dihydroquinazolin-4(1H)-one starting from isatoic anhydride via a three-step reaction. The resulting 2-amino-N-substituted benzamides from the reaction of isatoic anhydride and benzylamines underwent coupling cyclization reaction with 4-(prop-2-yn-1-yloxy)benzaldehyde, and then click reaction with in situ prepared organic azides afforded the title compounds in good yields. Graphical abstract: [Figure not available: see fulltext.] © 2016, Springer-Verlag Wien.

Style	Citing Format
MLA	Mahdavi M, et al.. "Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One." Monatshefte fur Chemie, vol. 147, no. 12, 2016, pp. 2151-2156.
APA	Mahdavi M, Saeedi M, Karimi M, Foroughi N, Hasanshahi F, Alinezhad H, Foroumadi A, Shafiee A, Akbarzadeh T (2016). Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One. Monatshefte fur Chemie, 147(12), 2151-2156.
Chicago	Mahdavi M, Saeedi M, Karimi M, Foroughi N, Hasanshahi F, Alinezhad H, Foroumadi A, Shafiee A, Akbarzadeh T. "Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One." Monatshefte fur Chemie 147, no. 12 (2016): 2151-2156.
Harvard	Mahdavi M et al. (2016) 'Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One', Monatshefte fur Chemie, 147(12), pp. 2151-2156.
Vancouver	Mahdavi M, Saeedi M, Karimi M, Foroughi N, Hasanshahi F, Alinezhad H, et al.. Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One. Monatshefte fur Chemie. 2016;147(12):2151-2156.
BibTex	@article{ author = {Mahdavi M and Saeedi M and Karimi M and Foroughi N and Hasanshahi F and Alinezhad H and Foroumadi A and Shafiee A and Akbarzadeh T}, title = {Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One}, journal = {Monatshefte fur Chemie}, volume = {147}, number = {12}, pages = {2151-2156}, year = {2016} }
RIS	TY - JOUR AU - Mahdavi M AU - Saeedi M AU - Karimi M AU - Foroughi N AU - Hasanshahi F AU - Alinezhad H AU - Foroumadi A AU - Shafiee A AU - Akbarzadeh T TI - Synthesis of Novel 1,2,3-Triazole Derivatives of 2,3-Dihydroquinazolin-4(1H)-One JO - Monatshefte fur Chemie VL - 147 IS - 12 SP - 2151 EP - 2156 PY - 2016 ER -

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