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Burden of Ischemic Heart Disease and Its Attributable Risk Factors in 204 Countries and Territories, 1990-2019 Publisher Pubmed



Safiri S1, 2, 3 ; Karamzad N4 ; Singh K5, 6, 7 ; Carsonchahhoud K8, 9 ; Adams C10 ; Nejadghaderi SA2, 11 ; Almasihashiani A12 ; Sullman MJM13, 14 ; Mansournia MA15 ; Bragazzi NL16 ; Kaufman JS17 ; Collins GS18, 19 ; Kolahi AA20
Authors
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Authors Affiliations
  1. 1. Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Cardiology, Gold Coast University Hospital, Gold Coast, QLD, Australia
  6. 6. Department of Medicine, Griffith University, Southport, QLD, Australia
  7. 7. Department of Medicine, Bond University, Robina, QLD, Australia
  8. 8. Australian Centre for Precision Health, University of South Australia, Adelaide, SA, Australia
  9. 9. School of Medicine, University of Adelaide, Adelaide, SA, Australia
  10. 10. Department of Medicine, Royal Brisbane and Women's Hospital, Herston, QLD, Australia
  11. 11. Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  12. 12. Department of Epidemiology, School of Health, Arak University of Medical Sciences, Arak, Iran
  13. 13. Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus
  14. 14. Department of Social Sciences, University of Nicosia, Nicosia, Cyprus
  15. 15. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  16. 16. Centre for Disease Modelling, York University, Toronto, ON, Canada
  17. 17. Department of Epidemiology Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada
  18. 18. Centre for Statistics in Medicine, NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom
  19. 19. NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
  20. 20. Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: European Journal of Preventive Cardiology Published:2022


Abstract

Aims: To report the prevalence, deaths, and disability-adjusted life years (DALYs) associated with ischemic heart disease (IHD) and its attributable risk factors in 204 countries and territories from 1990 to 2019, by age, sex, and socio-demographic index (SDI). Methods and results: Ischemic heart disease was defined as acute myocardial infarction (MI) and chronic IHD (angina; asymptomatic IHD following MI). Cause of death ensemble modelling was used to produce fatality estimates. The prevalence of the non-fatal sequalae of IHD was estimated using DisMod MR 2.1. All estimates were presented as counts and age-standardized rates per 100 000 population. In 2019, IHD accounted for 197.2 million (177.7-219.5) prevalent cases, 9.1 million (8.4-9.7) deaths, and 182.0 million (170.2-193.5) DALYs worldwide. There were decreases in the global age-standardized prevalence rates of IHD [-4.6% (-5.7,-3.6)], deaths [-30.8% (-34.8,-27.2)], and DALYs [-28.6% (-33.3,-24.2)] from 1990 to 2019. In 2019, the global prevalence and death rates of IHD were higher among males across all age groups, while the death rate peaked in the oldest group for both sexes. A negative association was found between the age-standardized DALY rates and SDI. Globally, high systolic blood pressure (54.6%), high low-density lipoprotein cholesterol (46.6%), and smoking (23.9%) were the three largest contributors to the DALYs attributable to IHD. Conclusion: Although the global age-standardized prevalence, death, and DALY rates all decreased. Prevention and control programmes should be implemented to reduce population exposure to risk factors, reduce the risk of IHD in high-risk populations, and provide appropriate care for communities. © 2021 Published on behalf of the European Society of Cardiology. All rights reserved.
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