Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives
Loghman Firoozpour
Loghman Firoozpour

Assistant Professor of Pharmaceutical Chemistry

Drug Design and Development Research Center

Tehran University of Medical Sciences

All Documents
1. Co-Assembly of Zwitterionic Surfactant-Like Peptides With Fatty Acids at the Solid–Liquid Interface of Magnetic Nanoparticles Improves Their Water Dispersibility, Morphology, and Size Distribution, Chemical Papers (2025)
2. Design, Synthesis, and Evaluation of Triazolo[1,5-A]Pyridines As Novel and Potent Α‑Glucosidase Inhibitors, Scientific Reports (2025)
3. Critical Aggregation Concentration Can Be a Predictor of Doxorubicin Delivery Performance of Self-Assembling Amphiphilic Peptides With Different Hydrophobic Tails, Journal of Pharmaceutical Sciences (2024)
4. Design, Synthesis, and Biological Evaluation of New Biaryl Derivatives of Cycloalkyl Diacetamide Bearing Chalcone Moiety As Type Ii C-Met Kinase Inhibitors, Molecular Diversity (2024)
5. Design, Synthesis, and Evaluation of Novel Substituted Imidazo[1,2-C]Quinazoline Derivatives As Potential Α-Glucosidase Inhibitors With Bioactivity and Molecular Docking Insights, Scientific Reports (2024)
6. Identification of Furo[2,3-D]Pyrimidin-4-Ylsulfanyl-1,3,4-Thiadiazole Derivatives As Novel Flt3-Itd Inhibitors, European Journal of Medicinal Chemistry (2024)
7. Jellein-I-Conjugated Gold Nanoparticles: Insights Into the Antibacterial, Antibiofilm Activities Against Mrsa, and Anticancer Properties, Journal of Drug Delivery Science and Technology (2024)
8. Synthesis, Biological Activities, and Molecular Docking Studies of Triazolo[4,3-B]Triazine Derivatives As a Novel Class of Α-Glucosidase and Α-Amylase Inhibitors, Archiv der Pharmazie (2024)
9. Synthesis, Biological Evaluation, and in Silico Study of Novel Coumarin-Quinazoline Analogs As Potential Anti-Angiogenesis Agents, Results in Chemistry (2024)
10. Synthesis, Molecular Docking, and Biological Evaluation of Pyridin-3-Yl-Pyrimidin-2-Yl-Triazole Derivatives As Anti-Cancer Agents, Polycyclic Aromatic Compounds (2024)
11. A Dft Study on the Transition Metal Doped Bn and Aln Nanocages As a Drug Delivery Vehicle for the Cladribine Drug, Journal of Molecular Liquids (2023)
12. Design of Experiments Approach for the Development of a Validated Method to Determine the Exenatide Content in Poly(Lactide-Co-Glycolide) Microspheres, European Journal of Pharmaceutics and Biopharmaceutics (2023)
13. Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives, Medicinal Chemistry Research (2023)
14. Enrichment of Carbopol Gel by Natural Peptide and Clay for Improving the Burn Wound Repair Process, Polymer Bulletin (2023)
15. Imidazo[1,2-A]Quinazolines As Novel, Potent Egfr-Tk Inhibitors: Design, Synthesis, Bioactivity Evaluation, and in Silico Studies, Bioorganic Chemistry (2023)
16. Imidazo[1,2-C]Quinazolines As a Novel and Potent Scaffold of Α-Glucosidase Inhibitors: Design, Synthesis, Biological Evaluations, and in Silico Studies, Scientific Reports (2023)
17. Imidazopyridine-Based Kinase Inhibitors As Potential Anticancer Agents: A Review, Bioorganic Chemistry (2023)
18. Novel Fluoroquinolones Analogues Bearing 4-(Arylcarbamoyl)Benzyl: Design, Synthesis, and Antibacterial Evaluation, Molecular Diversity (2023)
19. Polysaccharide-Based Hydrogel Enriched by Epidermal Growth Factor Peptide Fragment for Improving the Wound Healing Process, Heliyon (2023)
20. Review of Toxicology 2-Ethoxyethanol, Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 (2023)
21. Review of Toxicology Acetophenone, Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 (2023)
22. Review of Toxicology Epichlorohydrin, Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 (2023)
23. Synthesis, Α-Glucosidase Inhibitory Activity and Docking Studies of Novel Ethyl 1,2,3-Triazol-4-Ylmethylthio-5,6-Diphenylpyridazine-4-Carboxylate Derivatives, BMC Chemistry (2023)
24. Tannic Acid-Mediated Synthesis of Flower-Like Mesoporous Mno2 Nanostructures As T1–T2 Dual-Modal Mri Contrast Agents and Dual-Enzyme Mimetic Agents, Scientific Reports (2023)
25. The Synergistic Effect of Chimeras Consisting of N-Terminal Smac and Modified Kla Peptides in Inducing Apoptosis in Breast Cancer Cell Lines, Biochemical and Biophysical Research Communications (2023)
26. The Synthesis and the Mechanism of a Five-Membered Ring Formation Between an Isothiocyanate and an Amide Leading to the Yield of Enzalutamide Anticancer Api; a Joint Experimental and Theoretical Study, Journal of Molecular Structure (2023)
27. Thienopyrimidine-Based Agents Bearing Diphenylurea: Design, Synthesis, and Evaluation of Antiproliferative and Antiangiogenic Activity, Archiv der Pharmazie (2023)
28. What Is the Role of Phytochemical Compounds As Capping Agents for the Inhibition of Aggregation in the Green Synthesis of Metal Oxide Nanoparticles? a Dft Molecular Level Response, Inorganic Chemistry Communications (2023)
29. An Industrial Approach to Production of Tofacitinib Citrate (Tfc) As an Anti-Covid-19 Agent: A Joint Experimental and Theoretical Study, Journal of Chemistry (2022)
30. Antidiabetic and Neuroprotective Effects of a Novel Repaglinide Analog, Journal of Biochemical and Molecular Toxicology (2022)
31. Design, Synthesis and Evaluation of Novel Tetrahydropyridothienopyrimidin-Ureas As Cytotoxic and Anti-Angiogenic Agents, Scientific Reports (2022)
32. Matrixyl Patch Vs Matrixyl Cream: A Comparative in Vivo Investigation of Matrixyl (Mti) Effect on Wound Healing, ACS Omega (2022)
33. Novel Coumarin–Pyridine Hybrids As Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer’S Disease, Frontiers in Chemistry (2022)
34. Ph-Responsive Chitosan-Modified Gadolinium Oxide Nanoparticles Delivering 5-Aminolevulinic Acid: A Dual Cellular and Metabolic T1-T2* Contrast Agent for Glioblastoma Brain Tumors Detection, Journal of Molecular Liquids (2022)
35. Polysaccharide-Based Hydrogels Containing Herbal Extracts for Wound Healing Applications, Carbohydrate Polymers (2022)
36. Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer’S Disease, Frontiers in Chemistry (2022)
37. The Situation of Small Molecules Targeting Key Proteins in Combatting Sars-Cov-2: Synthesis, Metabolic Pathway, Mechanism of Action, and Potential Therapeutic Applications, Mini-Reviews in Medicinal Chemistry (2022)
38. Corrigendum to “Design, Synthesis and Evaluation of Novel Thienopyrimidine-Based Agents Bearing Diaryl Urea Functionality As Potential Inhibitors of Angiogenesis” [Eur. J. Med. Chem 209 (2021) 112942] (European Journal of Medicinal Chemistry (2021) 209, (S0223523420309144), (10.1016/J.Ejmech.2020.112942)), European Journal of Medicinal Chemistry (2021)
39. Design, Synthesis and Biological Assessment of New 1-Benzyl-4-((4-Oxoquinazolin-3(4H)-Yl)Methyl) Pyridin-1-Ium Derivatives (Bops) As Potential Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase, Heliyon (2021)
40. Design, Synthesis and Evaluation of Novel Thienopyrimidine-Based Agents Bearing Diaryl Urea Functionality As Potential Inhibitors of Angiogenesis, European Journal of Medicinal Chemistry (2021)
41. Design, Synthesis, Andin Vitroandin Vivoevaluation of Novel Fluconazole-Based Compounds With Promising Antifungal Activities, ACS Omega (2021)
42. Design, Synthesis, Molecular Docking, and in Vitro Α-Glucosidase Inhibitory Activities of Novel 3-Amino-2,4-Diarylbenzo[4,5]Imidazo[1,2-A]Pyrimidines Against Yeast and Rat Α-Glucosidase, Scientific Reports (2021)
43. Novel Descriptors Derived From the Aggregation Propensity of Di- and Tripeptides Can Predict the Critical Aggregation Concentration of Longer Peptides, ACS Omega (2021)
44. Quinazolin-4(3H)-One Based Agents Bearing Thiadiazole-Urea: Synthesis and Evaluation of Anti-Proliferative and Antiangiogenic Activity, Bioorganic Chemistry (2021)
45. Synthesis, In-Vitro Evaluation, Molecular Docking, and Kinetic Studies of Pyridazine-Triazole Hybrid System As Novel Α-Glucosidase Inhibitors, Bioorganic Chemistry (2021)
46. An Efficient and Targeted Synthetic Approach Towards New Highly Substituted 6-Amino-Pyrazolo[1,5-A]Pyrimidines With Α-Glucosidase Inhibitory Activity, Scientific Reports (2020)
47. Design and Synthesis of Benzodiazepine-1,2,3-Triazole Hybrid Derivatives As Selective Butyrylcholinesterase Inhibitors, Molecular Diversity (2020)
48. Design and Synthesis of Novel Pyridazine N-Aryl Acetamides: In-Vitro Evaluation of Α-Glucosidase Inhibition, Docking, and Kinetic Studies, Bioorganic Chemistry (2020)
49. Design, Synthesis and Enzymatic Inhibition of Novel Unusual Amino Acids As a Transition State Analogue of Amyloid Precursor Protein Peptide, International Journal of Peptide Research and Therapeutics (2020)
50. Design, Synthesis, and Biological Evaluation of 1-(5-(Benzylthio)-1,3,4-Thiadiazol-2-Yl)-3-Phenylurea Derivatives As Anticancer Agents, Medicinal Chemistry Research (2020)
51. Efficient Synthesis, Biological Evaluation, and Docking Study of Isatin Based Derivatives As Caspase Inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry (2020)
52. Site Directed Disulfide Pegylation of Interferon-Β-1B With Fork Peptide Linker, Bioconjugate Chemistry (2020)
53. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
54. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
55. Synthesis and Radioligand-Binding Assay of 2,5-Disubstituted Thiadiazoles and Evaluation of Their Anticonvulsant Activities, Archiv der Pharmazie (2020)
56. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
57. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
58. Folic Acid Decorated Magnetic Nanosponge: An Efficient Nanosystem for Targeted Curcumin Delivery and Magnetic Resonance Imaging, Journal of Colloid and Interface Science (2019)
59. A Convenient Method for the Synthesis of Chromeno[4,3-B]Pyridines Via Three-Component Reaction, Combinatorial Chemistry and High Throughput Screening (2018)
60. A One-Pot, Three-Component, Solvent-Free Synthesis of Novel 6H-Chromeno[3’,4’:5,6]Pyrido[2,3-D]Pyrimidine-Triones Under Microwave Irradiation, Journal of Chemical Research (2018)
61. Copper-Catalyzed Synthesis of 2,3-Disubstituted Quinazolin-4(3H)-Ones From Benzyl-Substituted Anthranilamides, Heterocyclic Communications (2018)
62. Design, Synthesis and Characterization of Novel Urolithin Derivatives As Cholinesterase Inhibitor Agents, Letters in Drug Design and Discovery (2018)
63. N-Substituted Piperazinyl Sarafloxacin Derivatives: Synthesis and in Vitro Antibacterial Evaluation, DARU# Journal of Pharmaceutical Sciences (2018)
64. Novel 3-Phenylcoumarin–Lipoic Acid Conjugates As Multi-Functional Agents for Potential Treatment of Alzheimer's Disease, Bioorganic Chemistry (2018)
65. Synthesis and Biological Evaluation of 2-Phenyl Benzothiazole Derivatives As Cytotoxic Agents, Journal of Sciences# Islamic Republic of Iran (2018)
66. Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors, Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences (2018)
67. Synthesis and Biological Evaluation of New Coumarins Bearing 2,4-Diaminothiazole-5-Carbonyl Moiety, European Journal of Medicinal Chemistry (2018)
68. Synthesis and Cholinesterase Inhibitory Activity of New 2-Benzofuran Carboxamide-Benzylpyridinum Salts, Bioorganic Chemistry (2018)
69. Synthesis of 2,4,5-Triaryl-1H-Imidazoles Under Kornblum Oxidative Condition, Letters in Organic Chemistry (2018)
70. Synthesis, Docking Study, and Biological Evaluation of Novel Umbellipherone/Hymecromone Derivatives As Acetylcholinesterase/Butyrylcholinesterase Inhibitors, Medicinal Chemistry Research (2018)
71. Synthesis, Evaluation, and Molecular Docking Studies of Aryl Urea-Triazole-Based Derivatives As Anti-Urease Agents, Archiv der Pharmazie (2018)
72. An Efficient Approach to the Synthesis of Coumarin-Fused Dihydropyridinones, Heterocyclic Communications (2017)
73. An Efficient Four-Component Reaction for the Synthesis of Chromeno[4,3-B]Quinolone Derivatives, Journal of the Iranian Chemical Society (2017)
74. Facile Synthesis and Antiproliferative Activity of 7H-Benzo[7,8]Chromeno[2,3-D]Pyrimidin-8-Amines, European Journal of Medicinal Chemistry (2017)
75. New Racemic Annulated Pyrazolo[1,2-B]Phthalazines As Tacrine-Like Ache Inhibitors With Potential Use in Alzheimer's Disease, European Journal of Medicinal Chemistry (2017)
76. New Tacrine-Derived Ache/Buche Inhibitors: Synthesis and Biological Evaluation of 5-Amino-2-Phenyl-4H-Pyrano[2,3-B]Quinoline-3-Carboxylates, European Journal of Medicinal Chemistry (2017)
77. Synthesis and Anti-Acetylcholinesterase Activity of N-[(Indolyl)Ethyl)- Coumarin-Yloxy)]Alkanamides, Journal of Chemical Research (2017)
78. Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives, Chemical Biology and Drug Design (2017)
79. Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives As Anticancer Agents, Letters in Drug Design and Discovery (2017)
80. A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride, Tetrahedron Letters (2016)
81. An Efficient Four-Step Approach Toward Fused Triazino[1,6-A] Quinazolines, Combinatorial Chemistry and High Throughput Screening (2016)
82. Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents, Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences (2016)
83. Efficient Three-Step Synthesis of Benzo[E]Imidazo[1,2-C][1,2,3]Triazines, Synthetic Communications (2016)
84. One-Pot Synthesis of Oxoisoindoline-1,2,3-Triazole Hybrid by a Ugi–Click Reaction, Synthetic Communications (2016)
85. Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase, Journal of Enzyme Inhibition and Medicinal Chemistry (2016)
86. Sulfonic Acid Supported Phosphonium Based Ionic Liquid Functionalized Sba-15 for the Synthesis of 2-Amino-3-Cyano-4,6-Diarylpyridines, Synthesis and Reactivity in Inorganic# Metal-Organic and Nano-Metal Chemistry (2016)
87. Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems, Journal of Chemical Sciences (2016)
88. Synthesis and Antiacetylcholinesterase Activity Evaluation of New 2-Aryl Benzofuran Derivatives, Letters in Drug Design and Discovery (2016)
89. Benzofuran-Derived Benzylpyridinium Bromides As Potent Acetylcholinesterase Inhibitors, European Journal of Medicinal Chemistry (2015)
90. Efficient Multi-Component Synthesis of 1,4-Benzodiazepine-3,5-Diones: A Petasis-Based Approach, Tetrahedron (2015)
91. N-(2-(Piperazin-1-Yl)Phenyl)Arylamide Derivatives As Β-Secretase (Bace1) Inhibitors: Simple Synthesis by Ugi Four-Component Reaction and Biological Evaluation, Archiv der Pharmazie (2015)
92. Novel N-2-(Furyl)-2-(Chlorobenzyloxyimino) Ethyl Piperazinyl Quinolones: Synthesis, Cytotoxic Evaluation and Structure-Activity Relationship, Iranian Journal of Pharmaceutical Research (2015)
93. Simple and Efficient Syntheses of Novel Benzo[4,5]Imidazo[1,2-A]Pyridine Derivatives, Tetrahedron Letters (2015)
94. Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives As New Acetylcholinesterase Inhibitors, Archiv der Pharmazie (2015)
95. Synthesis and Evaluation of Coumarin-Resveratrol Hybrids As 15-Lipoxygenaze Inhibitors, Synthetic Communications (2015)