Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Metformin and Aspirin: Anticancer Effects on A549 and Pc3 Cancer Cells and the Mechanisms of Action
Leila Safaeian
Leila Safaeian

Professor of Pharmacology

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences

Pharmaceutical Sciences Research Center

Isfahan University of Medical Sciences

All Documents
1. Cardioprotective Potential of Protocatechuic Acid Against Doxorubicin-Induced Cardiotoxicity in Rats, Research in Pharmaceutical Sciences (2025)
2. Cardiovascular Protective Effects of Cinnamic Acid As a Natural Phenolic Acid: A Review, Archives of Physiology and Biochemistry (2025)
3. Cardioprotective Effects of Total and Anthocyanin-Rich Extracts of Opuntia Ficus-Indica Fruit on Epinephrine-Induced Cardiac Injury in Rats, Asian Pacific Journal of Tropical Biomedicine (2024)
4. Novel Triazine-Tyrosine Hybrids Containing Thiyazol or Pyridine Fragment As Anti-Multiple Sclerosis Agents: Design, Synthesis, Biological Evaluation, and Molecular Docking Study, Heliyon (2024)
5. The Effect of Dracocephalum Subcapitatum Hydroalcoholic Extract on Dexamethasone-Induced Hyperlipidemic Rats, Research in Pharmaceutical Sciences (2024)
6. Allium Affine Extract Improves Dexamethasone-Induced Hyperlipidemia in Rats, Research Journal of Pharmacognosy (2023)
7. An Overview of Animal Models Induced by Glucocorticoids, Physiology and Pharmacology (Iran) (2023)
8. Andrographolide Protects Against Doxorubicin-And Arsenic Trioxide-Induced Toxicity in Cardiomyocytes, Molecular Biology Reports (2023)
9. Asian Pacific Journal of Tropical Biomedicine Cardioprotective Effects of Pinus Eldarica Bark Extract on Adrenaline-Induced Myocardial Infarction in Rats, Asian Pacific Journal of Tropical Biomedicine (2023)
10. Protective Effects of Protocatechuic Acid Against Doxorubicin- and Arsenic Trioxide-Induced Toxicity in Cardiomyocytes, Research in Pharmaceutical Sciences (2023)
11. Antihyperlipidemic and Antioxidant Effects of Ethanol Fraction of Sargassum Angustifolium in Dexamethasone-Induced Dyslipidemic Rats, Research Journal of Pharmacognosy (2022)
12. Evolocumab, a Pcsk9 Inhibitor, Protects Human Endothelial Cells Against H2o2-Induced Oxidative Stress, Archives of Physiology and Biochemistry (2022)
13. In Vivo Assessment of Bone Repair by an Injectable Nanocomposite Scaffold for Local Co-Delivery of Autologous Platelet-Rich Plasma and Calcitonin in a Rat Model, Drug Development and Industrial Pharmacy (2022)
14. Pramlintide: An Amylin Analogue Protects Endothelial Cells Against Oxidative Stress Through Regulating Oxidative Markers and Nf-Κb Expression, International Journal of Preventive Medicine (2022)
15. Calcitonin-Loaded Octamaleimic Acid–Silsesquioxane Nanoparticles in Hydrogel Scaffold Support Osteoinductivity in Bone Regeneration, Pharmaceutical Development and Technology (2021)
16. Effect of Face-To-Face Education on Knowledge, Attitudes, and Practices Toward “Traffic Light” Food Labeling in Isfahan Society, Iran, International Quarterly of Community Health Education (2021)
17. Holothurin B Isolated From Holothuria Atra Inhibits Angiogenesis More Potent Than Curcumin in Vitro, Research Journal of Pharmacognosy (2021)
18. Cardioprotective Effect of Vanillic Acid Against Doxorubicin-Induced Cardiotoxicity in Rat, Research in Pharmaceutical Sciences (2020)
19. Citral Protects Human Endothelial Cells Against Hydrogen Peroxide-Induced Oxidative Stress; [Sitral, Insan Endotel Hucrelerini Hidrojen Peroksitin Neden Oldugu Oksidatif Strese Karsi Korur], Turkish Journal of Pharmaceutical Sciences (2020)
20. Encapsulation of Imatinib in Targeted Kit-5 Nanoparticles for Reducing Its Cardiotoxicity and Hepatotoxicity, Anti-Cancer Agents in Medicinal Chemistry (2020)
21. Polyhedral Oligomeric Silsesquioxane /Platelets Rich Plasma/Gelrite-Based Hydrogel Scaffold for Bone Tissue Engineering, Current Pharmaceutical Design (2020)
22. The Effect of Pramlintide, an Antidiabetic Amylin Analogue, on Angiogenesis-Related Markers in Vitro, Research in Pharmaceutical Sciences (2020)
23. Antioxidant and Anti-Hyperlipidemic Effects of Bark Extract of Pinus Eldarica in Dexamethasone-Induced Dyslipidemic Rats, Journal of Advances in Medical and Biomedical Research (2019)
24. Evolocumab, a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor, Promotes Angiogenesis in Vitro, Canadian Journal of Physiology and Pharmacology (2019)
25. In Vitro Antioxidant Effects of Different Extracts Obtained From the Leaves and Seeds of Allium Ampeloprasum Subsp. Persicum, Journal of HerbMed Pharmacology (2019)
26. Antihyperlipidemic Effect of Different Fractions Obtained From Teucrium Polium Hydroalcoholic Extract in Rats, International Journal of Preventive Medicine (2018)
27. Antihypertensive and Antioxidant Effects of Protocatechuic Acid in Deoxycorticosterone Acetate-Salt Hypertensive Rats, Biomedicine and Pharmacotherapy (2018)
28. Creating and Validating E-Cases As Educational Tools in General Practitioners' Continuing Medical Education Context, Bio-Algorithms and Med-Systems (2018)
29. Portulaca Oleracea Seeds Extract Does Not Prevent Dexamethasone-Induced Hypertension in Rats, Journal of HerbMed Pharmacology (2018)
30. The Effect of Celecoxib on Blood Pressure and Plasma Oxidant/Antioxidant Status in Co-Administration With Glucocorticoid in Rat, Biomedicine and Pharmacotherapy (2018)
31. The Effects of Hydroalcoholic Extract of Allium Elburzense Wendelbo Bulb on Dexamethasone-Induced Dyslipidemia, Hyperglycemia, and Oxidative Stress in Rats, Research in Pharmaceutical Sciences (2018)
32. The Effects of Hydroalcoholic Extract of Allium Elburzense Wendelbo Bulb on Dexamethasone-Induced Dyslipidemia, Hyperglycemia, and Oxidative Stress in Rats, Research in Pharmaceutical Sciences (2018)
33. Evaluation of Fibrinolytic and Antioxidant Effects of Allium Affine Hydroalcoholic Extract, Research in Pharmaceutical Sciences (2017)
34. Evaluation of Fibrinolytic and Antioxidant Effects of Allium Affine Hydroalcoholic Extract, Research in Pharmaceutical Sciences (2017)
35. A Review on Epidemiology of Clostridium Difficile Infection, Tehran University Medical Journal (2016)
36. Cytoprotective Effect of Hydroalcoholic Extract of Pinus Eldarica Bark Against H2o2-Induced Oxidative Stress in Human Endothelial Cells, Iranian Biomedical Journal (2016)
37. Gender Differences in a Mouse Model of Chemotherapy-Induced Neuropathic Pain, Laboratory Animals (2016)
38. Preparation and Evaluation of Clove Oil in Emu Oil Self-Emulsion for Hair Conditioning and Hair Loss Prevention, Journal of HerbMed Pharmacology (2016)
39. Protective Effect of Melissa Officinalis Extract Against H2o2-Induced Oxidative Stress in Human Vascular Endothelial Cells, Research in Pharmaceutical Sciences (2016)
40. The Effect of Protocatechuic Acid on Blood Pressure and Oxidative Stress in Glucocorticoid-Induced Hypertension in Rat, Iranian Journal of Pharmaceutical Research (2016)
41. Antihypertensive and Antioxidant Effects of a Hydroalcoholic Extract Obtained From Aerial Parts of Otostegia Persica (Burm.) Boiss, Research in Pharmaceutical Sciences (2015)
42. Seasonality and Physician‑Related Factors Associated With Antibiotic Prescribing: A Cross‑Sectional Study in Isfahan, Iran, International Journal of Preventive Medicine (2015)
43. The Effect of Hydroalcoholic Extract of Ferula Foetida Stems on Blood Pressure and Oxidative Stress in Dexamethasone-Induced Hypertensive Rats, Research in Pharmaceutical Sciences (2015)
44. Assessing the Prescription Writing Principles in Medical Students' Prescriptions During Internship, Journal of Isfahan Medical School (2014)
45. The Role of Bcl-2 Family Proteins in Pulmonary Fibrosis, European Journal of Pharmacology (2014)
46. Antihypertensive Effect of Lactoferrin on Dexamethasone-Induced Hypertension in Rat, Journal of Isfahan Medical School (2013)
47. Comparison of Bleomycin-Induced Pulmonary Apoptosis Between Nmri Mice and C57bl/6 Mice, Research in Pharmaceutical Sciences (2013)
48. Prescribing Quality in Medical Specialists in Isfahan, Iran, Iranian Journal of Pharmaceutical Research (2013)
49. Pattern of Self-Medication With Analgesics Among Iranian University Students in Central Iran, Journal of Family and Community Medicine (2012)
50. General Physicians and Prescribing Pattern in Isfahan, Iran, Oman Medical Journal (2011)
51. Is There a Relationship Between Admission Blood Glucose Level Following Acute Poisoning and Clinical Outcome?, Archives of Medical Science (2011)
52. Mutation of the Histidin Residue of the Drh Motif in Vasopressin V2 Receptor Expression and Function, DARU, Journal of Pharmaceutical Sciences (2010)
53. The Effect of Aspartate-Lysine-Isoleucine and Aspartate-Arginine-Tyrosine Mutations on the Expression and Activity of Vasopressin V2 Receptor Gene, Iranian Biomedical Journal (2010)
54. The Effect of At1 Receptor Blockade on Bax and Bcl-2 Expression in Bleomycin-Induced Pulmonary Fibrosis, Daru (2009)
55. The Role of Strain Variation in Bax and Bcl-2 Expression in Murine Bleomycin-Induced Pulmonary Fibrosis, Pakistan Journal of Biological Sciences (2008)
56. Development and Time-Course of Bleomycin-Induced Pulmonary Fibrosis in Nmri Mice, Daru (2007)
57. Pneumonia Associated With a Single Intratracheal Dose of Bleomycin in Mice, Lab Animal (2006)